Showing titles in History & Commentary

Leading transplant surgeon Dr. Joshua Mezrich creates life from loss, moving organs from one body to another. In this intimate, profoundly moving work, he examines more than one hundred years of remarkable medical breakthroughs, connecting this fascinating history with the stories of his own patients. Gripping and evocative, How Death Becomes Life takes us inside the operating room and presents the stark dilemmas that transplant surgeons must face daily.

For 4,000 years, the size and vitality of cities, economies, and empires were heavily determined by infection. Striking humanity in waves, the cycle of plagues set the tempo of civilizational growth and decline, since common response to the threat was exclusion — quarantining the sick or keeping them out. But the unprecedented hygiene and medical revolutions of the past two centuries have allowed humanity to free itself from the hold of epidemic cycles — resulting in an urbanized, globalized, and unimaginably wealthy world.

In the early 1960s, Dr. Frances Oldham Kelsey of the U.S. Food and Drug Administration became one of the most celebrated women in America when she prevented a deadly sedative from entering the U.S. market. A Canadian-born pharmacologist and physician, Kelsey saved countless Americans from the devastating side effects of thalidomide, routinely given to pregnant women to prevent morning sickness. As the FDA medical officer charged with reviewing Merrell Pharmaceutical’s application for approval, Kelsey was unconvinced that there was sufficient evidence of the drug’s efficacy and safety.

Again and again, microbes have shaped our health, our genetics, our history, our culture, our politics, even our religion and ethics. This book reveals much that scientists and cultural historians have learned about the pervasive interconnections between infectious microbes and humans. It also considers what our ongoing fundamental relationship with infectious microbes might mean for the future of the human species.

In Germany on Christmas Day 1956 a baby girl was born without ears. She was the first victim of the notorious thalidomide epidemic. There would be over 10,000 more across 46 countries. For years the world believed the United States had avoided the catastrophe. After Frances Kelsey at the FDA became suspicious of the dangers of thalidomide in 1960, she led a successful fight to block its commercial approval. But now, having probed government and corporate archives and interviewed hundreds of key players, Jennifer Vanderbes reveals a darker truth that lay buried for decades.

Vaccines are a debate, whether we want them to be or not. With a clear-eyed approach to their science and history, How Vaccines Work demystifies the strange and intricate world of vaccines: it explains what a vaccine is, how they are developed and what happens when they meet our bodies.

In Lost, medical historian Shannon Withycombe weaves together women’s personal writings and doctors’ publications from the 1820s through the 1910s to investigate the transformative changes in how Americans conceptualized pregnancy, understood miscarriage, and interpreted fetal tissue over the course of the 19th century. Withycombe’s pathbreaking research reveals how Americans construed, and continue to understand, miscarriage within a context of reproductive desires, expectations, and abilities.

In the 16th century, when explorers travelled deep into the jungles of South America in search of gold and spices, they brought back many colourful tales of their adventures. None of these tales was more astonishing, or caused more concern, than that of the mystical properties of the substance with which the natives anointed their darts and arrows.

In Good Blood, best-selling writer Julian Guthrie tells the gripping tale of the race to cure a horrible affliction known as Rh disease that stalked families and caused a mother’s immune system to attack her own unborn child. The story is anchored by two very different men on two continents: Dr. John Gorman in New York, who would land on a brilliant yet contrarian idea, and the unassuming Australian whose almost magical blood - and his unyielding devotion to donating it - would save millions of lives.

Weaving together family history, genetic discovery, and scenes from her life, Ami McKay tells the compelling, true-science story of her own family's unsettling legacy of hereditary cancer while exploring the challenges that come from carrying the mutation that not only killed many people you loved, but might also kill you.

Until the 1970s, if you suffered a medical crisis, your chances of survival were minimal. A 9-1-1 call might bring police or even the local funeral home. But that all changed with Freedom House EMS in Pittsburgh, a group of Black men who became America’s first paramedics and set the gold standard for emergency medicine around the world, only to have their story and their legacy erased—until now.

Seamus O'Mahony writes about the illusion of progress, the notion that more and more diseases can be "conquered" ad infinitum. He punctures the idiocy of consumerism, the idea that healthcare can be endlessly adapted to the wishes of individuals. He excoriates the claims of Big Science, the spending of vast sums on research follies like the Human Genome Project. And he highlights one of the most dangerous errors of industrialized medicine: an over-reliance on metrics, and a neglect of things that can't easily be measured, like compassion.

Smallpox, the only infectious disease to have been eradicated, was one of the most terrifying of human scourges. It covered the skin with hideous, painful boils, killed a third of its victims, and left the survivors disfigured for life. In this riveting, often terrifying look at the history of smallpox, Jonathan B. Tucker tells the story of this deadly disease, the heroic efforts to eradicate it worldwide, and the looming dangers it still poses today.

Almost daily, headlines announce newly discovered links between cancers and their genetic causes. Science journalist Jessica Wapner vividly relates the backstory behind those headlines, reconstructing the crucial breakthroughs, explaining the science behind them, and giving due to the dozens of researchers, doctors, and patients whose curiosity and determination restored the promise of a future to the more than 50,000 people diagnosed each year with chronic myeloid leukemia (CML).

What happens to consciousness during the act of dying? The most compelling answers come from people who almost die and later recall events that occurred while lifesaving resuscitation, emergency care, or surgery was performed. These events are now called near-death experiences (NDEs). As medical and surgical skills improve, innovative procedures can bring back patients who have traveled farther on the path to death than at any other time in history. Physicians and healthcare professionals must learn how to appropriately treat patients who report an NDE.

Ever since the 1918 Spanish influenza pandemic, Scientists have dreamed of preventing catastrophic outbreaks of infectious disease. Yet, despite a century of medical progress, viral and bacterial disasters continue to take us by surprise, inciting panic and dominating news cycles. From the Spanish flu and the 1924 outbreak of pneumonic plague in Los Angeles, to the 1930 'parrot fever' pandemic and the more recent SARS, Ebola and Zika, the last 100 years have been marked by a succession of unanticipated pandemic alarms.

When British-born Elizabeth Blackwell earned her medical degree in America in 1849, there was an international outcry. Few at the time would have disagreed with the actress Fanny Kemble's remark - "What, trust a woman doctor - never!"

Stanley Aylett's remarkable account of six years' service as a front-line surgeon with the British Army is that rare thing: a complete narrative from the first week of the Second World War until months after the final capitulation of Nazi Germany. That war was the last Western conflict in which military surgeons performed operations immediately behind the front line, often in makeshift theatres set up in tents or abandoned, battle-scarred buildings. Surgeon at War records the resilience and resourcefulness of the medical teams.

Today, 90 percent of psychiatric beds are located in jails and prisons across the United States, institutions that confine disproportionate numbers of African Americans. After more than a decade of research, the celebrated scholar and activist Mab Segrest locates the deep historical roots of this startling fact, turning her sights on a long-forgotten cauldron of racial ideology: the state mental asylum system in which psychiatry was born and whose influences extend into our troubled present.

Few diseases are more gruesome than typhus. Transmitted by body lice, it afflicts the dispossessed - refugees, soldiers, and ghettoized peoples - causing hallucinations, terrible headaches, boiling fever, and often death. The disease plagued the German army on the Eastern Front and left the Reich desperate for a vaccine. For this they turned to the brilliant and eccentric Polish zoologist Rudolf Weigl.