Showing titles in History & Commentary

An updated edition of the classic history of schizophrenia in America, which gives voice to generations of patients who suffered through "cures" that only deepened their suffering and impaired their hope of recovery.

The Tudor dynasty died out because there was no heir of Elizabeth I's body to succeed her. Henry VIII, despite his six marriages, had produced no legitimate son who would live into old age. Three of the reigning Tudors (Edward VI, Mary I, and Elizabeth I) died without heirs apparent, the most tragic case being that of Mary Tudor, who went through two recorded cases of phantom pregnancy. If it were not for physical frailty and the lack of reproductive health among the Tudors, the course of history might have been different.

Since their advent, antibiotics have saved millions of lives, marking one of the greatest medical advances in our history. Dangerous Miracle weaves together the grand arc of the evolution of antibiotics over millions of years with a history of the past century: first as we mined the earth for naturally occurring antibiotic molecules, then as we learned to synthesise our own. But like fossil fuels, antibiotics are a finite resource which we’ve regarded as a cheap, everlasting fuel.

Drawing on Crampton’s own experience of surviving a life-threatening disease only to find herself beset by almost constant anxiety about her health, A Body Made of Glass explores part of the landscape of illness that most memoirs don’t reach: the territory beyond survival or cure, where body and mind seem locked in a strange and exhausting kind of dance. The result is both a fascinating cultural history of hypochondria and a moving account of what it means to live with this invisible, elusive and increasingly widespread condition.

Dripping with blood and gold, fetishised and tortured, gateway to earthly delights and point of contact with the divine, forcibly divided and powerful even beyond death, there was no territory more contested than the body in the medieval world. In Medieval Bodies, art historian Jack Hartnell uncovers the complex and fascinating ways in which the people of the Middle Ages thought about, explored and experienced their physical selves.

For 4,000 years, the size and vitality of cities, economies, and empires were heavily determined by infection. Striking humanity in waves, the cycle of plagues set the tempo of civilizational growth and decline, since common response to the threat was exclusion — quarantining the sick or keeping them out. But the unprecedented hygiene and medical revolutions of the past two centuries have allowed humanity to free itself from the hold of epidemic cycles — resulting in an urbanized, globalized, and unimaginably wealthy world.

Over the past two decades, we have started talking more about common mental health conditions like depression and anxiety. But complex conditions like schizophrenia, bipolar disorder and psychosis have been left behind, as have many of the people who live with these conditions or who care for them. Part memoir, part deep-dive investigation, The One Thing We've Never Spoken About is filled with rage at how our nation's public discourse, emergency services and healthcare systems continue to fail so many people.

Mark Gober dives into fundamental beliefs about health and disease. These beliefs are so fundamental, in fact, that most of us probably haven’t thought to question them. For example, do bacteria cause disease, or are they part of the body’s cleanup crew that appears at the scene of an underlying toxicity or injury? Do researchers follow the scientific method when they claim to isolate viruses and show that they cause disease in their hosts? In addition to exploring these essential questions, Gober goes a layer deeper by examining the nature of consciousness.

Investigative journalist Zuckerman takes us inside the top-secret laboratories, corporate clashes and high-stakes government negotiations that led to effective shots. Deeply reported and endlessly gripping, this is a dazzling blow-by-blow chronicle of the most consequential scientific breakthrough of our time. It's a story of courage, genius and heroism. It's also a tale of heated rivalries, unbridled ambitions, crippling insecurities and unexpected drama. A Shot to Save the World is the story of how science saved the world.

These outspoken writings by the founder of modern nursing record fundamentals in the needs of the sick that must be provided in all nursing. Nightingale covers such timeless topics as ventilation, noise, food, bed and bedding, light, cleanliness, and observation of the sick.

When it comes to illness, sometimes the end is just the beginning. Recovery and convalescence are words that exist at the periphery of our lives - until we are forced to contend with what they really mean. Here, GP and writer Gavin Francis explores how - and why - we get better, revealing the many shapes recovery takes, its shifting history and the frequent failure of our modern lives to make adequate space for it.

Despite advances in health care, infectious microbes continue to be a formidable adversary to scientists and doctors. Vaccines and antibiotics, the mainstays of modern medicine, have not been able to conquer infectious microbes because of their amazing ability to adapt, evolve, and spread to new places. Terrorism aside, one of the greatest dangers from infectious disease we face today is from a massive outbreak of drug-resistant microbes.

A decade after World War II, there was still no such thing as open-heart surgery, and yet half a million Americans were dying from heart disease every year. After the first daring operation in 1954 and through the next three decades, five heroic surgeons braved the scorn of their peers, withstood fierce desperation, and faced possible death in order to devise procedures that would save overwhelming numbers of those doomed children and provide hope for a new life to all manner of heart-failing individuals.

For most of human history, mental illness has been largely untreatable. Sufferers lived their lives - if they survived - in and out of asylums, accumulating life's wreckage around them. In 1948, all that changed when an Australian doctor and recently returned prisoner of war, working alone in a disused kitchen, set about an experimental treatment for one of the scourges of mankind - manic depression, or bipolar disorder. That doctor was John Cade and in that small kitchen he stirred up a miracle.

Upon its original publication, Plagues and Peoples was an immediate critical and popular success, offering a radically new interpretation of world history. With the identification of AIDS in the early 1980s, another chapter was added to this chronicle of events, which William McNeill explores in his introduction to this edition. McNeill’s highly acclaimed work is a brilliant and challenging account of the effects of disease on human history. His sophisticated analysis and detailed grasp of the subject make this book fascinating to listen to.

Defining "medicalization" as the perception of nonmedical conditions as medical problems and nondiseases as diseases, Thomas Szasz has devoted much of his career to exposing the dangers of "medicalizing" the conditions of some who simply refuse to conform to society's expectations. Szasz argues that modern psychiatry's tireless ambition to explain the human condition has led to the treatment of life's difficulties and oddities as clinical illnesses rather than as humanity revealed in its fullness.

In the late 1600s, a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth merchant, Antonie van Leeuwenhoek, look down their handmade microscopes. What they see introduces a radical concept that sweeps through biology and medicine, touching virtually every aspect of the two sciences and altering both forever. It is the fact that complex living organisms are assemblages of tiny self-contained, self-regulating units. Our organs, our physiology, our selves—hearts, blood, brains—are built from these compartments. Hooke christens them 'cells'.

Seamus O'Mahony writes about the illusion of progress, the notion that more and more diseases can be "conquered" ad infinitum. He punctures the idiocy of consumerism, the idea that healthcare can be endlessly adapted to the wishes of individuals. He excoriates the claims of Big Science, the spending of vast sums on research follies like the Human Genome Project. And he highlights one of the most dangerous errors of industrialized medicine: an over-reliance on metrics, and a neglect of things that can't easily be measured, like compassion.

Oliver Sacks died in August 2015 at his home in Greenwich Village, surrounded by his close friends and family. He was 82. He spent his final days doing what he loved: playing the piano, swimming, enjoying smoked salmon – and writing . . . As Dr Sacks looked back over his long, adventurous life...

Dementia, heart failure and cancer are now the leading causes of death in industrialised nations, where life expectancy is mostly above 80. A century ago, life expectancy was about 50 and people died mainly from infectious diseases. In the Middle Ages, death was mostly caused by famine, plague, childbirth and war. In the Palaeolithic period, where our species spent 95% of its time, we frequently died from violence and accidents.