In this video: Astaxanthin and Cancer Recovery | Samuel Shepherd
✅StemRegen: http://www.stemregen.co/drstephen
(Special Offer: Save 15% Using Code "SBPOD" At Checkout)
✅Nature's Marvels : https://profound-health.com/product-category/bioregulators/?aff=PODOF
(A Trusted Source for Natural & Synthetic Bioregulators)
✅Essential Energy : https://essentialenergy.solutions/?sca_ref=9026629.TgisoqpDPz
Your 10% discount code is POI10
( Photonic EMF Protection + Bio Tuning )
✅Approved Medical Sollutions: https://approvedmedicalsolutions.com/
(Non-licensed patients can use code "sbarrett" for a 10% discount.)
Please register your patients at - www.tremorstudy.com

What would you do if you were told you had anywhere from 10 minutes to 10 years to live?

In this episode, Dr. Barrett sit down with Samuel Shepherd, biochemical engineer, who shares his personal journey after being diagnosed with polycythemia vera, a rare blood disorder, and how that diagnosis led him to investigate the role of oxidative stress, free radicals, and cellular damage in chronic disease.

His research led him to study astaxanthin, a powerful carotenoid found in nature, and how it may influence inflammation, mitochondrial health, and oxidative balance at the cellular level.

This is not a typical supplement conversation. It's a deep dive into biochemistry, reactive oxygen species (ROS), protein misfolding, and immune signaling—and how these processes may be involved in conditions like cancer, diabetes, and neurodegenerative disease.

In this episode, we discuss:

➡️How oxidative stress and free radicals damage DNA and proteins
➡️The role of mitochondria and inflammation in chronic disease
➡️Why antioxidant defenses decline with age
➡️How protein misfolding may contribute to insulin resistance
➡️Why astaxanthin has become a major focus of his research

⚠️ Important: This episode is for educational discussion only and does not replace medical care. Cancer and chronic disease require professional diagnosis and treatment. Always consult qualified healthcare providers before making medical decisions.

If you're interested in biochemistry, longevity research, inflammation, and cellular health, this conversation will give you a new way to think about why disease develops—and what future research may reveal.

🔔 Subscribe for more conversations on cutting-edge health science and emerging medical ideas.

Follow Pod of Inquiry
📘 Facebook: https://www.facebook.com/podofinquiry
📸 Instagram: https://www.instagram.com/podofinquiry
🐦 X (Twitter): https://www.x.com/podofinquiry
🔗 LinkedIn (Dr. Stephen Barrett): https://www.linkedin.com/in/stephen-barrett-92776a51/

Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information.

Timestamps:
00:00 Introduction & Episode Overview
01:48 Sam's Medical Crisis Begins
02:43 Diagnosis: Polycythemia Vera
04:46 Treatment and Prognosis
06:30 The Question That Changed Everything
08:21 Discovery of a Common Thread
09:25 What Is Astaxanthin?
10:21 Algae Cultivation Technique
12:04 First Dosing Experiments
13:19 Dose Escalation Results
15:00 Mathematical Dose Projection
16:56 Effects at High Dose
17:04 Understanding the Mechanism
20:50 The Hydroxyl Free Radical
21:35 How Mutations Occur
22:51 Inflammation Marker Discovery
24:07 Glutathione and Aging Study
25:00 Antioxidant Decline After 50
27:07 Neutralizing Free Radicals
28:01 Commercial Production Begins
29:01 First Cancer Patient Case
29:52 High-Risk Treatment Decision
31:06 Dramatic Recovery
32:03 MD Anderson Findings
33:41 Blood Marker Discovery
35:00 Pathologist Confrontation
36:01 Expanding Treatment Cases
37:00 Glioblastoma Outcomes
37:48 Washington DC Presentation
38:57 NIH Research Funding
39:35 Diseases Linked to ROS
40:00 Protein Misfolding Mechanism
40:55 Insulin Resistance Explained
42:39 Type 2 Diabetes Effects
45:00 Alzheimer's Disease Mechanism
46:39 MIT Light Therapy Study
47:45 Non-Invasive Light Therapy
48:53 Two-Pronged Alzheimer's Strategy
49:53 The Role of ROS Balance

-- Hashtags --
#Astaxanthin #OxidativeStress #CellularHealth #LongevityScience #InflammationResearch #HealthPodcast #Biochemistry

✅StemRegen: http://www.stemregen.co/drstephen
(Special Offer: Save 15% Using Code "SBPOD" At Checkout)
✅Nature's Marvels : https://profound-health.com/product-category/bioregulators/?aff=PODOF
(A Trusted Source for Natural & Synthetic Bioregulators)
✅Essential Energy : https://essentialenergy.solutions/?sca_ref=9026629.TgisoqpDPz
Your 10% discount code is POI10
( Photonic EMF Protection + Bio Tuning )
✅Approved Medical Sollutions: https://approvedmedicalsolutions.com/
(Non-licensed patients can use code "sbarrett" for a 10% discount.)
Please register your patients at - www.tremorstudy.com

What if a 5-minute test could predict—with 90% accuracy—whether a $50,000 medication will actually work for you?

In this episode, Dr. Barrett sits down with Dr. Andrew Holman, rheumatologist and CEO of InMedix, to explore the hidden biology of stress and how it directly controls your immune system—millisecond by millisecond—through heart rate variability (HRV).

This isn't another generic "manage your stress" talk. We dive into measurable, clinical-grade HRV and how it's changing the way doctors predict treatment response in rheumatoid arthritis, autoimmune disease, and chronic pain.

In this episode, you'll learn:

➡️Why wearables like Oura Ring and Whoop don't tell the full clinical story
➡️The surprising link between sleep apnea and rheumatoid arthritis (even without snoring)
➡️How stress biologically regulates immune function in real time
➡️How an FDA-cleared HRV test measures both branches of the autonomic nervous system
➡️Why this technology could save $34 billion in healthcare costs over the next decade

The big takeaway: Stress isn't psychological—it's measurable physiology that may be sabotaging your treatment outcomes.

If you care about precision medicine, HRV, immune health, autoimmune disease, or longevity, this is a must-watch.

🔔 Subscribe for more deep dives into cutting-edge health science.

Follow Pod of Inquiry:
📘 Facebook: https://www.facebook.com/podofinquiry
📸 Instagram: https://www.instagram.com/podofinquiry
🐦 X (Twitter): https://www.x.com/podofinquiry
🔗 LinkedIn (Dr. Stephen Barrett): https://www.linkedin.com/in/stephen-barrett-92776a51/

Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information.

Timestamps:
00:00 Introduction & Episode Overview
01:38 Interview Begins
03:26 What Is Heart Rate Variability (HRV)?
04:02 HRV and the Autonomic Nervous System
05:00 Why HRV Matters Clinically
06:01 Consumer Wearables vs Medical-Grade HRV
08:18 Development of Cloud HRV Technology
09:33 Technical Requirements for Accurate HRV
10:00 Inside the Cloud HRV System
11:00 Measuring Both Sympathetic & Parasympathetic Systems
11:41 Interpreting Autonomic Measurements
13:09 Why HRV Matters in Medicine
14:27 Better Tools for Measuring Stress
14:41 Mainstream Recognition of Stress Biology
16:11 Vagus Nerve Stimulation & Immune Control
16:19 Medical School vs Modern Science
20:57 Clinical Applications & Treatment Strategy
22:39 Sleep Apnea and Rheumatoid Arthritis
23:07 Sleep Heart Health Study
23:31 Japanese RA Sleep Apnea Study
24:01 Effects of Treating Sleep Apnea
25:00 Key Lessons for Rheumatologists
25:45 The Future of Autonomic Medicine
27:19 Prevention & Risk Assessment
28:12 Predicting Rheumatoid Arthritis Risk
28:58 Restoring Physiologic Balance
29:09 Adoption of HRV in Clinical Practice
30:00 Availability & Insurance Coverage
31:34 Patient Perspectives on Stress
32:27 Future of Rheumatology Practice
33:08 Patient Demand & Treatment Limits
33:23 HRV as a Missing Vital Sign
34:10 Follow-Up Testing Strategies
34:44 Predicting Biologic Drug Response
36:27 Combination Therapy Study
38:58 East Meets West Medicine
39:08 Need for Objective Measurement
39:38 Restless Leg Syndrome & Nerve Entrapment
41:39 The Phoenix Sign Explained
42:14 Importance of Diagnostics
42:52 Atypical Disease Presentations
44:37 Economic Impact of Immuno-Autonomics
46:40 Autonomics Across Medicine
48:04 Stress, Strain, and Duress
48:40 Addressing Suffering in Medicine
50:00 About InMedix
51:01 Company Timeline & Funding
51:38 InMedix Mission
52:01 Business Development & Growth
53:35 Vision for the Future
53:56 Closing Remarks

-- Hashtags --
#HRV #StressScience #AutoimmuneHealth #RheumatoidArthritis #PrecisionMedicine #ImmuneSystem #LongevityScience

✅StemRegen: http://www.stemregen.co/drstephen
(Special Offer: Save 15% Using Code "SBPOD" At Checkout)
✅Nature's Marvels : https://profound-health.com/product-category/bioregulators/?aff=PODOF
(A Trusted Source for Natural & Synthetic Bioregulators)
✅Essential Energy : https://essentialenergy.solutions/?sca_ref=9026629.TgisoqpDPz
Your 10% discount code is POI10
( Photonic EMF Protection + Bio Tuning )
✅Approved Medical Sollutions: https://approvedmedicalsolutions.com/
(Non-licensed patients can use code "sbarrett" for a 10% discount.)
Please register your patients at - www.tremorstudy.com

What would you do if you truly believed you only had one life to live?

In this episode of Pod of Inquiry, Dr. Stephen Barrett sits down with Dr. Luke Cicchinelli, a podiatric surgeon who didn't just dream about change—he acted on it. Luke moved his family to Spain, learned Spanish through total immersion, and rebuilt his life overseas. Not once. Not twice. Three times—until it became permanent.

This conversation goes far beyond travel. It's about identity, courage, mortality, and what it really takes to live with intention.

In This Episode, You'll Discover:

➡️ How Luke learned Spanish from scratch—without apps, translators, or shortcuts
➡️ The concept of "purposeful ambiguity" and why it almost broke him
➡️ Why Spain's "work to live" culture may actually increase longevity
➡️ The #1 barrier that keeps people trapped in their comfort zones
➡️ How confronting mortality can be one of the most life-affirming experiences of all

Luke's story isn't about escaping—it's about choosing. Choosing growth over fear. Presence over routine. And giving his family the gift of cultural intelligence and a wider worldview.

If you've ever felt the pull to radically change your life—but didn't know where to start—this episode may be the permission you've been waiting for.

Follow Pod of Inquiry

📘 Facebook: https://www.facebook.com/podofinquiry
📸 Instagram: https://www.instagram.com/podofinquiry
🐦 X (Twitter): https://www.x.com/podofinquiry
🔗 LinkedIn (Dr. Stephen Barrett): https://www.linkedin.com/in/stephen-barrett-92776a51/

Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information.

Timestamps:
01:29 - Meeting Dr. Cicchinelli
03:28 - Timeline of Moves to Spain
05:48 - Learning Spanish
08:05 - The Immersion Process
10:00 - Current Language Use at Home
12:55 - Licensing and Bureaucracy
15:00 - Healthcare System Differences
18:31 - Moving to Vigo
24:54 - Serendipitous Connections
29:09 - Regional Languages and Culture
34:05 - Language at Home
38:36 - Biggest Challenge: Purposeful Ambiguity
44:35 - Quality of Life and Community
47:13 - Professional Training Reflection
49:14 - Recipe for Transformation
53:18 - Closing Thoughts

-- Hashtags --
#IntentionalLiving #LifeTransformation #ExpatLife #LivingAbroad #PersonalGrowth #PodcastEpisode #PodOfInquiry