Paediatric-onset multiple sclerosis before the age of 18 years, although uncommon, is associated with a higher disease burden than adult onset MS, early and progressive motor and cognitive disability, and high levels of depression and fatigue. In this episode Ann Yeh, Professor of Paediatrics and neurologist in Toronto, Canada, highlights the global considerations in preventing MS disease progression in young people with MS, including achieving global equity in access to diagnostics, specialist services, and highly-effective disease modifying therapies for adolescents and young adults with MS.

Read the Review in this month's issue here:

https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(25)00133-6/fulltext?dgcid=buzzsprout_icw_podcast_August_25_lanchi

Disease-modifying therapies in managing disability worsening in paediatric-onset multiple sclerosis: a longitudinal analysis of global and national registries https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(24)00047-6/fulltext?dgcid=buzzsprout_icw_podcast_August_25_lanchi

Real-life benefits of high-efficacy therapies for children with multiple sclerosis https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(24)00074-9/fulltext?dgcid=buzzsprout_icw_podcast_August_25_lanchi

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June 25, 2025, saw the publication of The Lancet Child & Adolescent Health Commission on the future of neonatology. The product of 3 years of dedicated international and interdisciplinary collaboration, the Commission builds on perspectives and experiences of clinical professionals who provide specialised care for neonates and are driven to develop evidence-based and equitable neonatal medicine that better serves newborn babies.

In this episode, Deputy Editor Josefine Gibson speaks to three commissioners about advancing neonatal medicine and the importance of interdisciplinary, inclusive research that centres on the health rights and care needs of newborn children to improve their health and wellbeing through childhood.

Read the Commission here:

https://www.thelancet.com/commissions-do/future-neonatology?dgcid=buzzsprout_icw_podcast_lanchineonatalrd25_lanchi

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Autism and ADHD continue to be the subjects of much debate and misunderstanding and until 2013 diagnostic manuals did not allow for the co-occurrence of autism and ADHD.

In this episode Thora Halldórsdóttir and Kristín Sigurdardottir, clinical psychologists and researchers from Iceland, join us to talk about the key findings from the study they led in Iceland that provides the first nationwide, population-based estimate of incidence and prevalence of autism, ADHD, and co-occurring autism-ADHD in young people without intellectual impairment between 2013 and 2021 assessed using gold-standard clinical methods.

They highlight that autism more often occurs in combination with ADHD than without, that the prevalence of co-occurring psychiatric conditions is high but not universal, and that the sex differences are not as large as previously thought.

Read the full article here:

https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(25)00132-4/fulltext?dgcid=buzzsprout_icw_podcast_Jun_25_lanchi

Other articles mentioned in this discussion:

Improving autism identification and support for individuals assigned female at birth: clinical suggestions and research priorities https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(23)00221-3/fulltext?dgcid=buzzsprout_icw_podcast_Jun_25_lanchi

Evidence-based kindness and empathy for autistic children https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(24)00080-4/fulltext?dgcid=buzzsprout_icw_podcast_Jun_25_lanchi

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