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The Bioactive Nexus - Elevating Your Supplement Knowledge!

The Bioactive Nexus - Elevating Your Supplement Knowledge!

By: Dr. Bill Clark and Dr. Gene Bruno
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Dive into the world of health and wellness with Dr. Bill and Dr. Gene on The Bioactive Nexus podcast. In each episode, they explore cutting-edge topics in the dietary supplement industry, from formulation and regulatory affairs to product development and market trends to the latest research, they cover it all. Whether you're a seasoned industry expert, a health enthusiast, or someone looking to learn more about the science behind supplements, their podcast has something for everyone. Tune in to gain expert knowledge and stay up to date on the future of dietary supplements.Dr. Bill Clark and Dr. Gene Bruno Hygiene & Healthy Living
Episodes
  • S2 EP29 – Inflammation - Calming the Fire Within with Nutraceutical Science
    Sep 14 2025

    In this episode, Dr. Bill Clark and Dr. Gene Bruno delve into the complexities of inflammation, particularly its role in aging and chronic diseases. They discuss the differences between acute and chronic inflammation, the molecular players involved, and how chronic inflammation accelerates age-related decline. The conversation also highlights the importance of nutraceuticals in managing inflammation and the best practices for formulating effective supplements. The episode emphasizes a proactive approach to health and the significance of evidence-based practices in the nutraceutical industry.


    Keywords

    inflammation, aging, nutraceuticals, chronic inflammation,health span, supplements, anti-inflammatory, wellness, longevity, immune system


    Takeaways

    - Inflammation can be both beneficial and harmfuldepending on its type.

    - Acute inflammation is necessary for healing,while chronic inflammation is detrimental.

    - NFKB is a key regulator in the inflammatoryprocess.

    - Oxidative stress and inflammation areinterconnected in a vicious cycle.

    - Chronic inflammation is linked to variousage-related diseases.

    - Nutraceuticals can help manage inflammationeffectively.

    - Using clinically relevant doses in formulationsis crucial.

    - Avoid the kitchen sink approach in supplementformulation.

    - Proactive health measures can mitigate theeffects of aging.

    - Evidence-based practices are essential foreffective nutraceuticals.


    Chapters

    00:00 Introduction to Inflammation and Aging

    07:21 Understanding Acute vs. Chronic Inflammation

    14:10 Molecular Players in Inflammation

    19:49 Impact of Chronic Inflammation on Aging

    20:42 Understanding Chronic Inflammation

    21:06 Exploring Anti-Inflammatory Botanicals

    22:15 Nutrients and Lipids in Inflammation Management

    24:35 The Role of Probiotics in Inflammation

    26:25 Innovative Compounds for Inflammation Relief

    28:13 The Power of Quercetin

    30:00 Best Practices for Formulating Anti-Inflammatory Products

    35:07 Proactive Approaches to Health and Inflammation

    38:56 Looking Ahead: Future Innovations in Nutraceuticals

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    43 mins
  • S2 EP28 – Personalized Nutrition – From One-Size-Fits-All to True Precision
    Aug 25 2025

    In this conversation, Dr. Bill Clark and Dr. Gene Brunoexplore the evolving landscape of personalized nutrition, discussing its definition, the spectrum of personalization, and the implications of emerging technologies. They emphasize the importance of scientific rigor and consumer trust in the industry, while also addressing the potential of biohacking and true precision nutrition. The discussion highlights the need for innovation and evidence-based approaches to meet the growing demand for personalized wellness solutions.


    Keywords

    personalized nutrition, precision nutrition, biohacking,nutraceuticals, health optimization, genomics, biomarkers, wellness, dietary supplements, health technology


    Takeaways

    · Personalized nutrition is about unique dietaryneeds for optimal health.

    · The spectrum of personalized nutrition rangesfrom generalized to true precision.

    · Most current personalized nutrition offeringsare not scientifically rigorous.

    · Wearable technology is enhancing thepersonalization of nutrition.

    · Biomarker-driven approaches are becoming moreaccessible and sophisticated.

    · Biohacking allows individuals to take control oftheir health but lacks regulation.

    · True precision nutrition combines various datainputs for tailored solutions.

    · Consumer demand is shifting towardsevidence-based personalized wellness.

    · The supplement industry must evolve to meetconsumer expectations for personalization.

    · Innovation and consumer trust are key to thefuture of personalized nutrition.


    Chapters

    00:00 Introduction to Personalized Nutrition

    02:55 Defining Personalized Nutrition

    06:07 The Spectrum of Personalized Nutrition

    08:53 Generalized Programs vs. Category-Based Personalization

    11:57 Lifestyle and Symptom-Based Personalization

    14:53 Biomarker Driven Personalization

    17:45 Biohacking and DIY Personalization

    18:52 Understanding Nutrigenomics and Biohacking

    21:13 The Future of Precision Nutrition

    26:13 Market Implications of Personalized Nutrition

    33:32 The Evolution of Evidence-BasedSupplementation

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    38 mins
  • S2 EP27 – Launch of NutriSelect Brand Science Accelerator
    Aug 18 2025

    In this special episode of The Bioactive Nexus, Dr. Gene Bruno interviews Dr. Bill Clark about the evolving state of the supplement industry and the launch of NutriSelect.ai, an innovative platform designed to enhance consumer trust and transparency.


    Dr. Clark shares how NutriSelect.ai is addressing industry challenges with evidence-based supplementation and personalized health technology, while also unveiling the Brand Science Accelerator — a groundbreaking program created to help supplement companies strengthen theirbrand, science, and consumer connection.


    This exclusive accelerator is now accepting applications,with only 5 brands invited to join the first cohort. Early movers will gain access to cutting-edge tools, strategy, and scientific insights to position their brand for growth in an increasingly competitive and regulated marketplace.


    If you’re ready to elevate your brand and lead the future ofsupplementation, this is the moment to step forward.


    👉 To learn more contact Dr. Bill Clark directly on LinkedIn or email at drbill@nutriselect.ai


    Keywords

    supplement industry, NutriSelect, consumer trust, AItechnology, Brand Science Accelerator, evidence-based supplementation, regulatory challenges, product evaluation, early movers, industry transformation


    Takeaways

    · The supplement industry is facing declining consumer trust.

    · NutriSelect aims to empower consumers by providing transparency.

    · There is a lack of standardized product evaluation in the industry.

    · Brands making unsupported claims will face increased scrutiny.

    · The NutriSelect app will provide objective ratings based on science.

    · Early movers in the industry will benefit from adapting to new standards.

    · The Brand Science Accelerator program helps brands improve their product efficacy.

    · Brands must invest in clinical research to remain competitive.

    · The industry is shifting towards evidence-based supplementation.

    · Consumer demand for transparency will drive industry change.


    Chapters

    00:00 Introduction to the Supplement ShakeOut

    02:26 Current Issues in the Supplement Industry

    07:20 The Role of NutriSelect in the Industry

    09:26 Opportunities for Early Movers

    10:55 The Brand Science Accelerator Program

    15:00 The Future of Supplement Brands

    19:41 Next Steps for Interested Brands

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    23 mins
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