Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-440

Overview: Explore current and emerging treatments for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a debilitating condition with no known cause or cure. Learn how oxaloacetate may offer new hope for patients struggling with ME/CFS, and gain practical guidance to support informed, evidence-based conversations with your patients.

Episode resource links:

• Cash A, Vernon SD, Rond C, Bateman L, et al. RESTORE ME: a RCT of oxaloacetate for improving fatigue in patients with myalgic encephalomyelitis/chronic fatigue syndrome. Front Neurol. 2024 Nov 27;15:1483876.
• Cash A, Kaufman DL. Oxaloacetate Treatment For Mental And Physical Fatigue In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long-COVID fatigue patients: a non-randomized controlled clinical trial. J Transl Med. 2022 Jun 28;20(1):295.
• CDC ME/CFS Basics Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Guest: Alan M. Ehrlich, MD, FAAFP Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-439

Overview: Nocturnal leg cramps (NLCs) are common in older adults, but current treatments often fall short or carry risks. Listen in as we explore new evidence on the safety and efficacy of vitamin K2 as a potential treatment for NLCs. Come away with practical insights to help you improve the sleep and quality of life of your patients.

Episode resource links:

• JAMA Intern Med. 2024;184(12):1443-1447. doi:10.1001/jamainternmed.2024.5726

Guest: Robert A. Baldor MD, FAAFP Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-438

Overview: In this episode, we review a major umbrella study linking physical activity to improvements in memory, executive function, and general cognition—offering you practical insights to guide patient counseling and provide evidence-based, nonpharmacologic strategies for dementia prevention and cognitive enhancement.

Episode resource links:

• Singh B, Bennett H, Miatke A, et al. Br J Sports Med. doi:10.1136/

Guest: Robert A. Baldor MD, FAAFP Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com