Sarah Richardson talks about her new exciting research on insulin producing beta-cells that are single cells or small clusters rather than in islets. These extra-islet beta-cells make up most of the insulin producing capacity of the pancreas in young children and are particularly susceptible to immune attack in Type 1 diabetes. This important research explains why the loss of insulin producing cells in Type 1 diabetes is more severe in young children and informs future work on treating and preventing Type 1 diabetes.

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Hannah Robinson was the first adult in the UK to be given the new immunotherapy drug Teplizumab, which aims to slow down the development of type 1 diabetes. Hannah had multiple pancreatic autoantibodies and hence is on the path to developing Type 1 diabetes (Series 4 Episode 3). Her consultant, Nick Thomas, arranged 14 consecutive daily hospital visits for her to receive the drug through a drip.

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Jerry Gore has always lived life on the edge; he had tackled some of the highest, and most inhospitable mountain climbs in the world before he was diagnosed with Type 1 diabetes aged 40. His Type 1 diabetes has not held him back and he has learnt how to live well with his Type 1 diabetes when climbing at extreme altitude and bitter cold. He helps people living with Type 1 diabetes throughout the world, especially in S E Asia as co-founder of Action4Diabetes (A4D). Rob Andrews is a national expert helping people with Type 1 diabetes to adapt their diabetes care so they can do any extreme activity including mountaineering, long distance swimming, and endurance cycling.

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