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Less of You: Life on Semaglutide & Tirzepatide

Less of You: Life on Semaglutide & Tirzepatide

By: Eva Sheie & Kami Gamlem
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Eva + Kami are two old-ish moms kids confronting our reasons for being obese while losing weight on semaglutide and tirzepatide, and roasting our past selves. Sarcasm is our happy place. Follow us on Instagram @lessofyoupodcast.

After a friend (who is a plastic surgeon) talked Eva into starting semaglutide in February of 2023, she lost 70 pounds in 14 months, alternating between long stretches of being stalled at the same weight and consistent but slow weight loss. Chasing a lifelong dream to being considered just overweight and not obese by the BMI calculator, after 14 months Eva switched to tirzepatide to try and reach a goal that still seems just out of reach.

A prolific eater of her feelings, Kami was tired of being uncomfortable and when she heard through a mutual friend how semaglutide had changed Eva’s life, she found a trusted medical weight loss provider and took the first step.

As Kami starts her life on semaglutide, Eva adjusts to a world with less food noise and figures out how to let go of the crippling negative self-talk.

On each episode, we connect on how our lives are changing in real time as semaglutide and tirzepatide help us be smaller people, and try to answer the bigger question for ourselves:

When there’s less of you, what is left?The Axis
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Episodes
  • I took a 4 week break from semaglutide and here’s what happened
    Nov 14 2025
    Eva gets ghosted in the middle of an important situation and spirals for a day. Kami stops her meds and finds out what it feels like to be hungry again after two years.

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    Eva + Kami are two old-ish moms with little kids confronting our reasons for being obese while losing weight on semaglutide and roasting our past selves. Sarcasm is our happy place.

    Are you confronting the same challenges? We’d love to hear your story. Send an email to podcasts@theaxis.io.

    To help others find great resources for GLP-1 medical weight loss programs, our new list of trusted semaglutide and tirzepatide providers is live & updated regularly at lessofyou.com

    To learn more about sponsoring this or for details on advertising opportunities on our cosmetic surgery and weight loss podcasts, request more info at theaxis.io.

    Follow us on Instagram @lessofyoupodcast

    Co-hosts: Eva Sheie & Kami Gamlem
    Assistant Producers: Mary Ellen Clarkson & Hannah Burkhart
    Engineering: Victoria Cheng
    Theme music: Old Grump, Smartface

    Less of You is a production of The Axis

    This episode includes AI-generated content.
    Show More Show Less
    37 mins
  • You Want Fries With That?
    Oct 3 2025
    After sewing a quilt on the floor, Kami’s back goes out. After kicking a dumbbell, her foot goes out too.

    New compounded meds including glycine and B12 make a noticeable dent in Eva’s persistent body aches. A 3-week pause in medication to get a tooth pulled has a surprising effect.

    We deconstruct our instincts to soften bad news by bribing our children with treats like McDonald’s.

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    Eva + Kami are two old-ish moms with little kids confronting our reasons for being obese while losing weight on semaglutide and roasting our past selves. Sarcasm is our happy place.

    Are you confronting the same challenges? We’d love to hear your story. Send an email to podcasts@theaxis.io.

    To help others find great resources for GLP-1 medical weight loss programs, our new list of trusted semaglutide and tirzepatide providers is live & updated regularly at lessofyou.com

    To learn more about sponsoring this or for details on advertising opportunities on our cosmetic surgery and weight loss podcasts, request more info at theaxis.io.

    Follow us on Instagram @lessofyoupodcast

    Co-hosts: Eva Sheie & Kami Gamlem
    Assistant Producers: Mary Ellen Clarkson & Hannah Burkhart
    Engineering: Spencer Clarkson
    Theme music: Old Grump, Smartface

    Less of You is a production of The Axis
    Show More Show Less
    31 mins
  • Replacing one addiction with another?
    Sep 5 2025
    While working on a project about addiction, Eva realizes she went from drinking and smoking to a food addiction. But she’s not even sure what her “thing” is now, which is… a little terrifying.

    Meanwhile, Kami loses some weight—not exactly from a wellness plan, but courtesy of stress and no sleep. Hey, a win’s a win.

    Eva + Kami are two old-ish moms with little kids confronting our reasons for being obese while losing weight on semaglutide and roasting our past selves. Sarcasm is our happy place.

    Are you confronting the same challenges? We’d love to hear your story. Send an email to podcasts@theaxis.io.

    To help others find great resources for GLP-1 medical weight loss programs, our new list of trusted semaglutide and tirzepatide providers is live & updated regularly at lessofyou.com

    To learn more about sponsoring this or for details on advertising opportunities on our cosmetic surgery and weight loss podcasts, request more info at theaxis.io.

    Follow us on Instagram @lessofyoupodcast

    Co-hosts: Eva Sheie & Kami Gamlem
    Assistant Producers: Mary Ellen Clarkson & Hannah Burkhart
    Engineering: Spencer Clarkson
    Theme music: Old Grump, Smartface

    Less of You is a production of The Axis
    Show More Show Less
    17 mins
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