Ellie Fisher loves most things about being a nurse in the emergency department . . . just not working with Regina Novak, an icy attending physician who acts as if she's God's gift to medicine. The dislike is completely mutual. Regina thinks Ellie is a starry-eyed romantic with a sentimental attitude that has no place at work. When Regina gets talked into volunteering at a singles auction, Ellie accidentally bids on her—and ends up winning. Oops! Since the money raised is for a good cause, they reluctantly decide to go through with the dates.

Boston Homicide Detective Caitlin Reagan walks a razor's edge, propping up her life on emotional constructs designed to help her manage grueling PTSD. She keeps her mother, boyfriend, and work separated and controlled, all in service to one horrible, tragic act she committed amid the Iraq war.

Since A-List actress and Hollywood's sweetheart Wren Acker came out, not only is she at the top of the acting world; she's also crush number one for her queer fanbase. Loving life, loving her job, loving her cat-everything is fantastic. Except that lack of any kind of private life. When a car accident brings her to the ER, the bottom falls out of her world when she realizes that reserved Doctor Taylor, her physician, is Madison Taylor from camp way back when she was a kid. And boy, does Madison still hold a well-earned grudge for how that all ended.

High-flying pediatric surgeon Emily Lawrence is new to Washington, DC. Her first week in her new job puts her on a collision course with the most powerful woman in America, President Calvin. Constance "Connie" Calvin's first term is proving turbulent thanks to trying to juggle work and life as a widowed single mother to a twelve-year-old boy. Running for re-election is imminent, and the critics are gunning for her. Worse, her famed icy cool is in danger of melting in the face of Emily's passion, commitment, and charm.

Scarlett Grey, disgraced assassin, is determined to get revenge. Quinn Adams, medic turned-poisoner for hire, is her deadliest rival. For years, they've stolen each other's clients, sabotaged each other's business, and occasionally… slept together. When the Magician Queen offers an irresistible deal, Scarlett and Quinn are forced to work together. But this is not a simple job. With an impossible heist ahead, they're going to have to trust each other… And that's not easy when they both have secrets to hide. Harder still when those secrets will betray the ones they love.