Greta Nilsson's trip west to save her ailing little sister, Astrid, could not have gone more wrong. First, bandits hold up her stagecoach, stealing all her money. Then, upon arriving in Fairplay, Colorado, she learns the man she was betrothed to as a mail-order bride has died. Homeless, penniless, and jobless, Greta and her sister are worse off than when they started. 

Living in London's poorest slum, Mercy Wilkins has little hope of a better life. When she's offered an opportunity to join a bride ship sailing to British Columbia, she agrees. After witnessing so much painful heartache and loss in the slums, the bride ship is her only prospect to escape a bleak future, not only for herself but, she hopes, someday for her sister. Wealthy and titled Joseph Colville leaves home and takes to the sea - as ship's surgeon - in order to escape the pain of losing his family. When Mercy becomes his assistant, the two must fight against a forbidden love. 

After years away, Astrid Nilsson has returned home to Colorado, hoping to become Fairplay’s second doctor...and to find healing for her reoccurring consumption. Spirited and independent, Astrid doesn’t want her illness to be a burden to those she loves, so she has resisted getting serious about any man.

The ultimate cure that could heal any disease? Crazy. That's exactly what research scientist Marian Creighton has always believed about her father's quest, even if it does stem from a desire to save her sister Ellen from the genetic disease that stole their mother from them. But when her father falls into a coma after drinking a vial of holy water believed to contain traces of residue from the Tree of Life, Marian must question all of her assumptions. He's left behind tantalizing clues that suggest he's crossed back in time. 

All Emma Chambers ever wanted was a home, but when her steamboat sinks just outside Presque Isle, she's left destitute and with no place to stay. An unlikely solution arises when the lighthouse keeper arrives in town. He's just lost his wife and is having a difficult time caring for his child. So a traveling preacher gets the idea that the keeper and Emma might be the answer to each other's dilemma.