Matthew Bartholomew, unorthodox but effective physician to Michaelhouse college in medieval Cambridge, is as worried as anyone about the pestilence that is ravaging Europe and seems to be approaching England. But he is distracted by the sudden and inexplicable death of the Master of Michaelhouse - a death the University authorities do not want investigated.

From some clear pieces of glass and a raven's feather, the great detective must divine exactly who the client was and what prompted him to seek assistance at 221B. Fortunately, Holmes has a number of experts upon whom he can rely as well as his own vast store of esoteric knowledge. Treading a twisted path, Holmes soon finds himself matching wits with an unseen criminal, who appears to be the equal of the late Professor Moriarty. At the same time, he is tasked with sparing the monarchy any possible embarrassment that may stem from the investigation.

London. A snowy December, 1888. Sherlock Holmes, 34, is languishing and back on cocaine after a disastrous Ripper investigation. Watson can neither comfort nor rouse his friend - until a strangely encoded letter arrives from Paris. Mlle La Victoire, a beautiful French cabaret star, writes that her illegitimate son by an English lord has disappeared, and she has been attacked in the streets of Montmartre.

Jesuit Priest Michael Dominic’s assignment to the Vatican’s legendary Secret Archives results in his discovery of a hidden papyrus: the unpublished writings of Mary Magdalene - a lost record buried in Rome’s deepest recesses. The forgotten relic’s heretical revelation threatens the Vatican’s very legitimacy, and pits Michael against ruthless and powerful enemies. Desperate, he reaches out to Hana Sinclair, an investigative reporter with a record of tackling contentious subjects.

For all we know, or think we know, about Sherlock Holmes and Doctor Watson, what we don’t know is far, far greater. In the duo’s first case, A Study in Scarlet, we learn that Holmes and Watson met on January 1st, 1881, and subsequently moved into an apartment together at 221b Baker Street. Their first case officially began on March 4th of that year, and it is argued that “The Adventure of the Resident Patient” possibly took place in October of 1881, depending on which version of the story you read. But what happened during the rest of 1881? Or all of 1882?