While visiting Japan, Wolverine is recruited to recover a stolen experimental drug, one that has the potential to be a true miracle cure for all human disease - or a sadistic means of enslaving the world. With every hour bringing mankind closer to tragedy, he embarks on a daring mission to identify the thieves and thwart their terrifying agenda.

The sequel to The Present and the conclusion of the Time's Arrow trilogy narrates the struggle of the X-Men and Spider-Man to stop the time-traveling madman Kang the Conqueror from destroying the multiverse and time as they know it.

Stark Enterprises has unleashed the Infinite Engine, which promises to be an energy source unlike anything ever seen before. But saboteurs from both A.I.M. and Hydra have set their sights on the engine as well - along with Dr. Doom. When a respected scientist is killed and the Engine taken over, Spiderman and Iron Man join forces to safeguard the Infinite Engine - and all of humanity.

This gripping new anthology has over a dozen original tales starring the top-selling mutant heroes, the uncanny X-Men, dealing with their greatest foes, as well as the day-to-day trials of being mutants - trying to protect the world they've sworn to protect, a world that hates them for what they are!

Centuries ago, a never-before-seen group of heroes gathered as the Avengers of their ancient era to fight the Zodiac, foes who wielded unimaginable arcane energies channeled through a mysterious Key. The resulting battle devastated vast swaths of the planet. The Key was lost, and the Zodiac went into hiding, influencing world events from the shadows, waiting for the stars to align to usher in their return. When strange beings exhibiting the traits of the 12 astrological signs appear in the 21st century, the Avengers again answer the call to assemble.