Oxford, Spring 1353. When young bookseller Nicholas Elyot discovers the body of student William Farringdon floating in the river Cherwell, it looks like a drowning. Soon, however, Nicholas finds evidence of murder. Who could have wanted to kill this promising student? As Nicholas and his scholar friend Jordain try to unravel what lies behind William's death, they learn that he was innocently caught up in a criminal plot.

Ralph Delchard, a soldier who fought at the Battle of Hastings, and Gervase Bret, a talented lawyer, have been commissioned by William the Conqueror to look into irregularities brought to light during the compilation of the Domesday Book. A man’s body is found mutilated in Savernake Forest and the residents of Bedwyn sleep uneasy at night, fearing a monster stalking the town. When Ralph Delchard and Gervase Bret arrive, they discover that the locals are harbouring dark secrets and that the real killer may be a little closer to home....

Hugh of Singleton, fourth son of a minor knight, has been educated as a clerk, usually a prelude to taking holy orders. However, feeling no certain calling despite a lively faith, he turns to the profession of surgeon, training in Paris and then hanging out his sign in Oxford. A local lord asks him to track the killer of a young woman whose bones have been found in the castle cesspit. She is identified as the impetuous missing daughter of a local blacksmith, and her young man, whom she had provoked very publicly, is in due course arrested and sentenced at the Oxford assizes.

Salisbury, 1226. A young pregnant woman is found tangled in reeds in the river Avon, her identity a mystery. Grieving widow Ela Longespée is determined to succeed her husband as sheriff of Salisbury, and quickly takes charge of the investigation. She soon finds herself in the thick of a neighborhood scandal and a struggle to maintain her authority. With multiple suspects, can she identify the true killer? 

Matthew Bartholomew, unorthodox but effective physician to Michaelhouse college in medieval Cambridge, is as worried as anyone about the pestilence that is ravaging Europe and seems to be approaching England. But he is distracted by the sudden and inexplicable death of the Master of Michaelhouse - a death the University authorities do not want investigated.