Three very different girls sign up as trainee nurses at a big London teaching hospital in 1934. Dora leaves her overcrowded, squalid working-class home for a better life. But has she got what it takes to keep up with other, better-educated girls? And will her hated stepfather ever let her go? Helen is born for the job; her brother is a doctor, her all-powerful mother a hospital trustee. But will Helen’s secret misery be her downfall? An aristocratic rebel, Millie’s carefree attitude will find her up in front of Matron again and again. Will she ever care enough to make a nurse? Or will she go back to the glamorous life she was born to?

It's the final year of training for three young nurses at The Nightingale Hospital. Helen is at a crossroads in her life as she battles with her domineering mother over both her love life and her future career. Dora can't stop loving Nick, who is married to her best friend, Ruby. Millie is anxious about her fiancé, sent to Spain to cover the Civil War, and things only get worse when she encounters a fortune teller who gives her a sinister warning.

Dora and her old enemy Lucy are paired up on the children's ward for the final three months of their training. The two nurses couldn't seem more different, but they may have more in common than they think, as each hides a secret heartache. And there are new faces. Jess is the feisty eldest daughter of a notorious East End family and determined to prove herself as a ward maid. New trainee nurse Effie can't wait to escape her small Irish village, and make her way as a nurse in London.

As the war takes its toll, the Nightingale nurses must do their bit for king and country... Dora is the devoted mother of twin babies, but, determined to help the war effort, she goes back to work at the Nightingale Hospital. More used to nights out in the West End, Jennifer and Cissy volunteer in the hope of tending to handsome soldiers. They soon find out that nursing isn’t quite what they were expecting.

As Christmas 1938 approaches, the staff at the Nightingale Hospital have their own wishes for the festive season. Ward sister Frannie Wallace is hoping she won't have to live through another war like the one that claimed her fiance. Staff Nurse Helen Dawson wants to find happiness again after the death of her husband Charlie. But is she looking for love in the wrong place? Matron Kathleen Fox struggles to keep up morale.

Matron Kathleen Fox has the job of putting the hospital back together but wonders if she is up to the task. In an attempt to bring some festive cheer, she decides to put on a Christmas show. The idea is greeted with mixed feelings by the nurses, who all have their own problems, and also by the new Assistant Matron and ward sister, who find themselves rivals for the role of organiser. But as rehearsals begin, the performers begin to find the show is not just a tonic for the patients.

It's Christmas 1941, and the nurses at the Nightingale are facing their toughest winter yet. With shortages everywhere and every news bulletin announcing more losses, the British people are weary and demoralised, and The Nightingale Hospital is suffering too. Millie is recently widowed and dealing with the demands of her family's estate. It's not long before her old world of the Nightingale begins to beckon, along with a long-lost love.... Jess is struggling with her move from East London to the countryside.

In the aftermath of a heartbreaking accident, Kirsty is shocked to discover that she has inherited a vineyard in Western Australia from Ed James, a lonely old man she befriended at the library. But there is a condition to his legacy: Kirsty must give up her quiet life in England and live at the vineyard for a least one year. How will a shy librarian cope on her own in a strange country? As she is forced to take her life off hold, one thing is certain, everything is about to change for Kirsty.

Anna is over the moon when her sweetheart returns from the front line. As he recovers from his injuries, they make plans to be married, but the horrors of the trenches cast a long shadow. Caring for shell-shocked soldiers brings untold challenges for Grace, and her parents have very different dreams for her future. Meanwhile Dulcie has her sights firmly set on her own happy ending. And yet sometimes we find love where we least expect to. Each of the nurses has her own battle to fight, but they must rally together if they’re to find true happiness.

London, 1914. While young men enlist up and down the country, the Nightingale Hospital has its own set of new recruits.... Anna Beck is the daughter of the best baker in Bethnal Green. Her German father built the business out of nothing, but as the shadow of war descends, his fate is at the mercy of their neighbours. Meanwhile Katie Carlyle has always wanted to become a doctor. She fought hard to get into medical school, and even now she faces prejudice from her fellow students as well as the tutors. Can she prove them wrong?

Welcome to the district nurses' home on Steeple Street, where everyone has a secret.... Ambitious young nurse Agnes Sheridan had a promising future ahead of her until a tragic mistake cost her the love and respect of everyone around her. Now she has come to Leeds for a fresh start as a trainee district nurse. But Agnes finds herself facing unexpected challenges as she is assigned to Quarry Hill, one of the city's most notorious slums.

There are new residents at Goodwill House—WAAF drivers Camilla ‘Millie’ Cunningham and Diane Forsyth, both eager to do their bit for the war effort and excited to help the brave boys who fly. And when Millie meets dashing and heroic Spitfire pilot Ted Thorrington, they strike up an instant connection. But with Hitler gaining more ground in Europe, there is danger brewing across the Channel in Dunkirk and Ted is required to fly more and more dangerous sorties, risking his life every time. With their hearts and lives on the line, the courage of the girls in blue will be tested.

Christmas Eve, 1936. On a foggy December night, a pregnant woman walks out in front of a trolley bus and is knocked unconscious. She is rushed to the Nightingale hospital, and a healthy baby is delivered. But the mother claims to have lost her memory, and cannot believe that the child is hers. It seems that the Nightingale nurses may need to perform a Christmas miracle.

London 1958. Life has moved on since the war, and the youngsters of Mulberry Lane are growing up fast. Peggy’s Ronaski’s family is struggling with growing pains, but she is always there, strong, reliable and ready to help whenever a crisis hits. Meanwhile, Maureen Hart has family problems of her own to contend with. Together they will work hard to conquer all of what life has to throw at them.

West Yorkshire, 1926. After completing her training in Steeple Street, Agnes is looking forward to making her mark as the village's first district nurse, confident she can make a difference in the locals' lives. But when she arrives, she's treated with suspicion, labelled just another servant of the wealthy mine owners. The locals would much rather place their trust in the resident healer, Nella Black.