It's the final year of training for three young nurses at The Nightingale Hospital. Helen is at a crossroads in her life as she battles with her domineering mother over both her love life and her future career. Dora can't stop loving Nick, who is married to her best friend, Ruby. Millie is anxious about her fiancé, sent to Spain to cover the Civil War, and things only get worse when she encounters a fortune teller who gives her a sinister warning.

Three very different girls sign up as trainee nurses at a big London teaching hospital in 1934. Dora leaves her overcrowded, squalid working-class home for a better life. But has she got what it takes to keep up with other, better-educated girls? And will her hated stepfather ever let her go? Helen is born for the job; her brother is a doctor, her all-powerful mother a hospital trustee. But will Helen’s secret misery be her downfall? An aristocratic rebel, Millie’s carefree attitude will find her up in front of Matron again and again. Will she ever care enough to make a nurse? Or will she go back to the glamorous life she was born to?

Dora and her old enemy Lucy are paired up on the children's ward for the final three months of their training. The two nurses couldn't seem more different, but they may have more in common than they think, as each hides a secret heartache. And there are new faces. Jess is the feisty eldest daughter of a notorious East End family and determined to prove herself as a ward maid. New trainee nurse Effie can't wait to escape her small Irish village, and make her way as a nurse in London.

As the war takes its toll, the Nightingale nurses must do their bit for king and country... Dora is the devoted mother of twin babies, but, determined to help the war effort, she goes back to work at the Nightingale Hospital. More used to nights out in the West End, Jennifer and Cissy volunteer in the hope of tending to handsome soldiers. They soon find out that nursing isn’t quite what they were expecting.

As Christmas 1938 approaches, the staff at the Nightingale Hospital have their own wishes for the festive season. Ward sister Frannie Wallace is hoping she won't have to live through another war like the one that claimed her fiance. Staff Nurse Helen Dawson wants to find happiness again after the death of her husband Charlie. But is she looking for love in the wrong place? Matron Kathleen Fox struggles to keep up morale.

It's Christmas 1941, and the nurses at the Nightingale are facing their toughest winter yet. With shortages everywhere and every news bulletin announcing more losses, the British people are weary and demoralised, and The Nightingale Hospital is suffering too. Millie is recently widowed and dealing with the demands of her family's estate. It's not long before her old world of the Nightingale begins to beckon, along with a long-lost love.... Jess is struggling with her move from East London to the countryside.

Matron Kathleen Fox has the job of putting the hospital back together but wonders if she is up to the task. In an attempt to bring some festive cheer, she decides to put on a Christmas show. The idea is greeted with mixed feelings by the nurses, who all have their own problems, and also by the new Assistant Matron and ward sister, who find themselves rivals for the role of organiser. But as rehearsals begin, the performers begin to find the show is not just a tonic for the patients.

London, 1914. While young men enlist up and down the country, the Nightingale Hospital has its own set of new recruits.... Anna Beck is the daughter of the best baker in Bethnal Green. Her German father built the business out of nothing, but as the shadow of war descends, his fate is at the mercy of their neighbours. Meanwhile Katie Carlyle has always wanted to become a doctor. She fought hard to get into medical school, and even now she faces prejudice from her fellow students as well as the tutors. Can she prove them wrong?

In 1820, Salem Street is sparkling and new: eight small terraced houses built by a Lancashire mill owner for his best workers. Annie Gibson's family is one of the first to move in - a step up in the world for them. But when her mother dies, Annie's happy childhood ends and she is left to bring up her brother and sister. Red-haired, intelligent and startlingly pretty, Annie soon finds herself banished from home by a jealous stepmother. She finds work in the local doctor's household, where she learns about the fascinating world outside Salem Street.

Anna is over the moon when her sweetheart returns from the front line. As he recovers from his injuries, they make plans to be married, but the horrors of the trenches cast a long shadow. Caring for shell-shocked soldiers brings untold challenges for Grace, and her parents have very different dreams for her future. Meanwhile Dulcie has her sights firmly set on her own happy ending. And yet sometimes we find love where we least expect to. Each of the nurses has her own battle to fight, but they must rally together if they’re to find true happiness.

West Yorkshire, 1926. After completing her training in Steeple Street, Agnes is looking forward to making her mark as the village's first district nurse, confident she can make a difference in the locals' lives. But when she arrives, she's treated with suspicion, labelled just another servant of the wealthy mine owners. The locals would much rather place their trust in the resident healer, Nella Black.

Welcome to the district nurses' home on Steeple Street, where everyone has a secret.... Ambitious young nurse Agnes Sheridan had a promising future ahead of her until a tragic mistake cost her the love and respect of everyone around her. Now she has come to Leeds for a fresh start as a trainee district nurse. But Agnes finds herself facing unexpected challenges as she is assigned to Quarry Hill, one of the city's most notorious slums.

Mary Vale, a grand and imposing Mother and Baby Home, sits on the remote Fylde coast in Lancashire. Its doors are open to unmarried women who come to hide their condition and find sanctuary. Women from all walks of life pass through Mary Vale, from beautiful waitress Emily, whose boyfriend has vanished without trace, to young Isla, cast out by her wealthy family after her first year at university goes horribly wrong. Awaiting them is Nurse Ada and Sister Anne who work tirelessly to aid the mothers and safely deliver the babies. 

After the heartbreak of World War Two, newlywed midwife Cathy hoped Liverpool life would offer some joy. But a terrible miscarriage and the escape of her abusive stepfather Jack from prison make happiness hard to find. Meanwhile, Cathy’s beloved granny is ailing. Whilst at the hospital, Cathy sees her midwifery friends, who are planning to open a home for unmarried mothers. After losing a baby of her own, Cathy would love to help, but for now, she must take care of her grandmother.  

Alice Lake has arrived in London from Liverpool to start her training as a District Nurse, but her journey has been far from easy. Her parents think that she should settle down and get married, but she has already had her heart broken once and isn’t about to make the same mistake again. Alice and her best friend, Edith, are based in the East End, but before they’ve even got their smart new uniforms on, war breaks out, and Hitler’s bombs are raining down on London.