Sienna Wilson is living her dream in the city - a rewarding obstetrics job in a leading hospital, an apartment with a view and handsome Sergeant McCabe on call whenever she needs him. The last thing she wants is a posting to a remote outback town to investigate a medical mystery. But on arrival in Spinifex, Sienna is brought to life in new and exciting ways. In a community riddled with secrets, she meets troubled young barmaid Maddy, and tough publican Alma, both with their troubles to hide.

Alice has always been a trailblazer as a scientist, activist, and mother. She knew her choices would involve sacrifices, but now, on the eve of her 80th birthday, she's beginning to wonder if she's sacrificed too much. Alice's daughter, Sappho, rebelled against her unconventional upbringing, choosing to marry young and embrace life as a homemaker, but her status as a domestic goddess has recently taken a surprising turn.

Lawson Cooper-Jones has two priorities in life - his son, Ned, and the survival of the dairy farm that has been in his family for generations. Despite the best efforts of the town matchmakers and the determined pursuit of local girl Adeline Walsh, Lawson's heart belongs still, and only, to his late wife. But when a flat tyre strands Lawson and Ned in nearby Rose Hill, he's surprised to find a woman living alone in the old general store of the deserted town. Ned immediately forms a bond with the beautiful stranger called Meg.

Dairy farmer Tabitha Cooper-Jones has a heart of gold, yet she's the eternal bridesmaid. Everyone's best mate. Despite facing some serious challenges over the years, she's built a successful ice-cream business and cafe, she's adored by her family and is an integral part of her hometown - there's just one thing missing from her life. But the last thing Tab wants is a man - or worse, love - to stop her achieving her dream. In town for a temporary teaching contract, Fergus McWilliams thinks the small community of Walsh will be the perfect place to stay under the radar....

Reserved high school teacher Keely Mitchell is more than ready for her holiday on the West coast of Australia, so when a medical emergency turns over all her plans and an intervention by a kind stranger finds her recovering in a Margaret River vineyard, she is at first downcast. Keely had wanted to put recent traumatic events out of her mind, and recuperating alone in a stranger's house won't help that. But slowly, the lovely food, spectacular wine and beautiful landscape of the area begin to work their spell.

Between managing a bustling beauty salon, hectic volunteer commitments and the lion's share of parenting two-year-old Claudia, Angie McIntyre barely has time to turn around. And with each passing month, she feels her relationship with fly-in, fly-out boyfriend Rob Jones slipping through her fingers. When Rob faces retrenchment and the most fabulous fixer-upper comes onto the market, Angie knows this derelict weatherboard cottage will be the perfect project to draw their little family together.

Alice Hamilton is enjoying her new life in Ballarat. She's learnt the hard way that knowledge is power and is looking forward to her legal studies, then making a difference as a lawyer with heart. But while Alice's life is looking up, back in Hope Springs the world of her former husband, Rick Peterson, is unravelling. After a chance meeting a few months earlier, Rick and Alice have reconnected. And it's fortunate they have, because Rick is about to need Alice's friendship like he's never needed it before.

When the father she barely knew dies suddenly, midwife Eve Wilson decides she owes it to him to go to the funeral and meet her step-family in Red Sand. After disappointment and heartbreak in Sydney, Dr Callie Wilson doesn't hesitate to move home and spend some time with her grieving mother. Melbourne-based obstetrician Sienna Wilson can't understand why anyone would want to bury themselves in the outback, but when her hospital sends her north to research the medical mystery affecting women in Red Sand, it seems fate is intent on bringing the three sisters together. 

Harriett Chirnwell has a perfect life - a husband who loves her, a successful career, and a daughter who is destined to become a doctor just like her. Xara has always lived in Harriet's shadow; her chaotic life with her family on their sheep farm falls far short of her older sister's standards of perfection and prestige. Georgie, the youngest sister and a passionate teacher, is the only one of the three to have left Billawarre. But is her life in Melbourne happy? All three sisters have a different and sometimes strained bond with their mother.

After her teenage daughter, Mia, falls in with the wrong crowd, Dr Billie Green decides it's time to leave the city and return home to Far Western NSW. When an opportunity to pursue her childhood dream of joining the Flying Doctor Service comes along, she jumps at the chance. Flight Nurse Daphne Prince - who is thrilled to have another woman join the otherwise male crew - and their handsome new boss, Morgan Blake, instantly make her feel welcome.

After losing her family farm to an aggressive global conglomerate, ambitious farmer Georgie Henderson manages Stoney Creek, a cattle farm in the New England region of NSW, spending every waking moment plotting and saving to buy Tamban back from those corporate vultures. When an unlikely meeting with Armani-clad businessman Michael Delacourt at a rowdy B&S Ball sends them on a whirlwind romance, Georgie can't believe it's possible for life to be this good. But her world shatters when she discovers the shocking secret Michael has been trying to keep from her.

Deira isn't the kind of woman to steal a car. Or drive to France alone with no plan. But then, Deira didn't expect to be single. Or to suddenly realise that that the only way she can get the one thing she wants most is to start breaking every rule she lives by. Grace has been sent on a journey by her late husband, Ken. She doesn't really want to be on it but she's following his instructions, as always. She can only hope that the trip will help her to forgive him. And then - finally - she'll be able to let him go. 

Alice Hunter is smarting from the raw deal life has thrown her way: suddenly single, jobless, and forced to move home to her parents' tiny seaside town. And now she faces an uncomfortable truth. She wants her twin sister Libby's enviable life. Libby's closest friend, Jess Dekic, has been around the Hunter family for so long she might as well be blood. She's always considered herself a sister closer to Libby than Alice ever could be.... Libby Hunter has all of life's boxes ticked. But when she is betrayed by those she loves most, it reveals how tenuous her world is....

Paula knew when she moved to the country that the life would be tough. Nearly a year into her marriage with farmer Dan, and now pregnant, she is proud of her ability to feed shearers, bake a pastie and fix a fence while still running her accountancy business from home. With a wedding to plan, the farm to run and neighbours to help out, life is busy but good. But there are clouds on the horizon.

A year after a tragic accident changed her life forever, Tess Daley is in desperate need of a change. When she is offered a position with the Flying Doctor Service, she seizes the opportunity to make a fresh start. Yet once she arrives in remote Mica Ridge she feels like an outsider, unable to connect with her patients and unsure if she'll ever fit in with this outback community. Station owner Soretta Byrnes has grown to love the company and chaos that comes with living in a house filled with boarders.