One wild night in the 1930s, midwife Patty Peel is called to attend a birth on the opposite side of Liverpool. She pedals off into the storm and delivers a baby girl in a filthy slum dwelling, just as the mother dies. The drunk and violent father tells Patty to get rid of it so she takes the child away, meaning to deliver it to the nearest orphanage. However, Patty spent her entire childhood in an institution, except for the frequent occasions when she ran away, and cannot bear to hand the baby over. 

Along a blacked-out wartime street a girl is scurrying, a basket on one arm. As sirens begin and bombs crash down, she is filled with panic and, with a heavy heart, abandons her burden in a sheltered doorway, meaning to return later. Even as she disappears in the resulting chaos, the bundle in the basket begins to wail.

Bristol, 1939. School leaver Maisie Miles suspects her father, a small-time crook, has an ulterior motive for insisting she gets a job at the W. D. & H. O. Wills tobacco factory but keeps it to herself. She's befriended by effervescent Phyllis Mason and kind-hearted Bridget Milligan who take pity on her and take Maisie under their wing. But beneath their happy-go-lucky exteriors, they all harbour dreams and worries about what the future holds. 

It's 1957, and three young women are beginning their nursing training at the Florence Nightingale Hospital in London's East End. Winne desperately wants to win her mother's approval - but will following in her footsteps and becoming a nurse help? Tearaway Viv has never been one to follow the rules, though the Nightingale may help her mend her ways. Beth is following her late sister's dream by training as a nurse. Will it be the right path for her? There's a steep learning curve ahead. But with friendship on their side, the Nightingale Daughters are ready to rise to the challenge.

As war looms in Europe, 18-year-old Jane Shaw runs the household as an unpaid servant on a meagre budget. When tragedy strikes and she loses her beloved younger brother in suspicious circumstances, Jane takes a position in service looking after Ned, a troubled young boy. Here she meets dashing David Heron, Ned's Uncle and they form an immediate attachment until she is dismissed after being accused of stealing a piece of jewellery. Returning home, Jane and her sister, Melia, are soon orphaned and left at the mercy of their Aunt Alice.