Lawson Cooper-Jones has two priorities in life - his son, Ned, and the survival of the dairy farm that has been in his family for generations. Despite the best efforts of the town matchmakers and the determined pursuit of local girl Adeline Walsh, Lawson's heart belongs still, and only, to his late wife. But when a flat tyre strands Lawson and Ned in nearby Rose Hill, he's surprised to find a woman living alone in the old general store of the deserted town. Ned immediately forms a bond with the beautiful stranger called Meg.

After more than 10 years away, Australian soap star Ellie Hughes returns to the small country town of Hope Junction, determined to remain anonymous while caring for her injured godmother, Matilda. But word spreads fast in the tight-knit community. It isn't long before the people of Hope are gossiping about the real reason for Ellie's visit and why she broke the heart of golden boy Flynn Quartermaine all those years ago.

Imogen Bates moved to the small rural town of Gibson's Find to start a new life for herself after the death of her husband. Tired of being haunted by the painful memories of her old life, Imogen set her last remaining hopes on the little town and poured her heart and savings into restoring the Majestic Hotel to its former glory. But while the female-starved town might be glad to see a young woman move in, not everyone is happy about Imogen's arrival. 

It's been more than 10 years since Maddy Locke left Spinifex, the small outback town where she gave birth to her daughter, Bridget. Now she's back to prove she's got what it takes to run the medical centre and face the memories of that challenging time in her life. But everything's changed - the old pub is gone, her new colleagues aren't pleased to see her and it's drier and hotter than ever.

Between managing a bustling beauty salon, hectic volunteer commitments and the lion's share of parenting two-year-old Claudia, Angie McIntyre barely has time to turn around. And with each passing month, she feels her relationship with fly-in, fly-out boyfriend Rob Jones slipping through her fingers. When Rob faces retrenchment and the most fabulous fixer-upper comes onto the market, Angie knows this derelict weatherboard cottage will be the perfect project to draw their little family together.

After a fractured childhood spent in foster homes, city girl Roni has convinced herself that she has no need of anyone - other than her not-as-tough-as-he-looks rescued street cat, Scritches, and her unborn baby. Despite facing a bleak future, Roni distrusts the news of a bequest from an unknown aunt, Marian Nelson. But, out of options, she and Scritches leave Sydney behind, bound for the 800-acre property on the edge of the wheat belt of South Australia. 

Burra District Hospital's maternity unit is under threat and will close for births unless a new obstetrician can be found. Midwife Noni Frost needs a miracle. A single mum, Noni lives with her young son, Harley, and her Aunt Win, a free spirit and the beating heart of Burra Guest House. Noni's world is disrupted when Iain McCloud and his pregnant teenage daughter Jacinta move into the guesthouse to await the birth of her baby. There's instant chemistry between Iain and Noni, although he has no plans to stay on in town. 

After her teenage daughter, Mia, falls in with the wrong crowd, Dr Billie Green decides it's time to leave the city and return home to Far Western NSW. When an opportunity to pursue her childhood dream of joining the Flying Doctor Service comes along, she jumps at the chance. Flight Nurse Daphne Prince - who is thrilled to have another woman join the otherwise male crew - and their handsome new boss, Morgan Blake, instantly make her feel welcome.

Harriett Chirnwell has a perfect life - a husband who loves her, a successful career, and a daughter who is destined to become a doctor just like her. Xara has always lived in Harriet's shadow; her chaotic life with her family on their sheep farm falls far short of her older sister's standards of perfection and prestige. Georgie, the youngest sister and a passionate teacher, is the only one of the three to have left Billawarre. But is her life in Melbourne happy? All three sisters have a different and sometimes strained bond with their mother.

Ashley has recently lost her husband. Daughter Emily is being bullied online. Best friend Nikki is holding a huge secret. And why is husband Chris receiving so many text messages lately? Their teenage children are glued to technology, be it PlayStation, YouTube, Instagram, Snapchat.... The two women hatch a plan: for three weeks, both families will stay in a rustic, remote coastal camp with no phone reception. 

In the small town of Little Heart, Juliette Kerr and Joel Hunter are drawn together by their shared experience being targeted by school bullies. But when the bullying takes a drastic turn, Juliette can see no other way to protect Joel from the aftermath than to break his heart and make him leave her behind. Devastated and confused, Joel packs his bags, heading far away in the heart of the outback to jackaroo at Rosalee Station for as long as it takes his heart to heal. A decade later, Joel returns to mend fences with his family....

Sienna Wilson is living her dream in the city - a rewarding obstetrics job in a leading hospital, an apartment with a view and handsome Sergeant McCabe on call whenever she needs him. The last thing she wants is a posting to a remote outback town to investigate a medical mystery. But on arrival in Spinifex, Sienna is brought to life in new and exciting ways. In a community riddled with secrets, she meets troubled young barmaid Maddy, and tough publican Alma, both with their troubles to hide.

A year after a tragic accident changed her life forever, Tess Daley is in desperate need of a change. When she is offered a position with the Flying Doctor Service, she seizes the opportunity to make a fresh start. Yet once she arrives in remote Mica Ridge she feels like an outsider, unable to connect with her patients and unsure if she'll ever fit in with this outback community. Station owner Soretta Byrnes has grown to love the company and chaos that comes with living in a house filled with boarders.

Alice Hamilton is enjoying her new life in Ballarat. She's learnt the hard way that knowledge is power and is looking forward to her legal studies, then making a difference as a lawyer with heart. But while Alice's life is looking up, back in Hope Springs the world of her former husband, Rick Peterson, is unravelling. After a chance meeting a few months earlier, Rick and Alice have reconnected. And it's fortunate they have, because Rick is about to need Alice's friendship like he's never needed it before.

When the father she barely knew dies suddenly, midwife Eve Wilson decides she owes it to him to go to the funeral and meet her step-family in Red Sand. After disappointment and heartbreak in Sydney, Dr Callie Wilson doesn't hesitate to move home and spend some time with her grieving mother. Melbourne-based obstetrician Sienna Wilson can't understand why anyone would want to bury themselves in the outback, but when her hospital sends her north to research the medical mystery affecting women in Red Sand, it seems fate is intent on bringing the three sisters together.