It is the 32nd millennium, and the Imperium is at peace. The Traitor Legions of Chaos are but a distant memory, and the many alien races that have long plagued mankind are held in check by the Space Marines. When a mission to exterminate one such xenos breed on the world of Ardamantua draws in more of their forces, the Imperial Fists abandon the walls of Terra for the first time in more than a thousand years.

As ork ships lay waste to world after world, heading inexorably towards Terra, Imperial citizens despair. The High Lords become desperate to prove that victory is possible, no matter the cost. A massive navy fleet is assembled - their mission to make a definitive strike against the orks at Port Sanctus, an area of enemy-held space. But when the Imperial armada arrives, they find themselves outclassed and outmanoeuvred. Can human courage and faith possibly prevail against such terrible odds?

Despite the Imperium's best attempts to forestall the ork plague that is wreaking havoc in human space, an ork attack moon now hangs over Terra. As its malevolent presence gazes down at the Imperial Palace, terrified citizens run riot in the streets. In a last-ditch attempt to destroy the attack moon, a proletarian crusade is launched. Thousands of ships large and small head to the moon carrying billions of citizens, all eager to take the fight to the enemy.

The Imperium's situation has never been more grim - an ork attack moon hangs over Terra, and ork armadas ravage human space. To make matters even worse, eldar strike at the heart of the Imperial Palace, forcing humanity's defenders to fight on two fronts at once. Though it seems nothing can stop the orks - neither brute force, science, nor faith - an unlikely alliance in the furthest reaches of space uncovers the first clue how to defeat the greenskins. The Adeptus Astartes now face an almost impossible task....

Paralysed by the continued ork invasion of Imperial space, the rulers of Terra continue to fight among themselves. Finally losing patience with the High Council, Koorland - the last surviving Imperial Fist - ousts the Lord Commander and seizes control. Elsewhere, the Fists Exemplar are forced by circumstance to fight alongside the Iron Warriors. Where will such an alliance lead - can a Traitor Legion ever be trusted?

The Imperium has been brought to the edge of extinction by an ork invasion of unprecedented scale and depth. Piecemeal strikes against the invaders prove ineffective - for every ork fleet destroyed, five more appear. The only solution is to find and kill the orks' warlord - the Great Beast. Surely if its leader is killed, the greenskins' empire will fall apart in agony of infighting and confusion.

Attached to Crusade Fleet Quintus - dubbed the Cursed Fleet by many - the Ultramarines of the Ithraca’s Vengeance are drawn to a stricken world. With millions enslaved, a malign necron technology siphons the souls of the innocent and heralds the Silent Kingdom’s expansion. The Ultramarines face an impossible decision: mount a desperate last stand to destroy the Pariah Nexus, or break away and damn the entire sector to bring word of this ancient foe’s resurgence to the only being capable of halting it - the Lord Primarch Roboute Guilliman.  

The attempt to hunt down and kill the orks' leader has ended in catastrophe. The Imperium is reeling from the loss of so many beloved heroes, and the military forces of mankind have been reduced to tatters. Koorland now knows that brute force is not the answer - but how else can the orks be fought? In a radical move, he creates small, mixed Chapter units of Adeptus Astartes - compact teams that will hit the enemy hard and fast and with deadly accuracy.

As the ork menace ravages the galaxy, the Imperium faces its darkest hour. Its fleets are in ruins, its armies devastated - amongst them the noble Imperial Fists - and even a primarch of myth has fallen against the Beast. As brute force fails, Koorland resorts to increasingly desperate tactics against the greenskins. A final hope lies in deploying the controversial Deathwatch and the Sisters of Silence in a deft strike at the heart of the ork empire.

The Traitor Host of Horus Lupercal tightens its iron grip on the Palace of Terra, and one by one the walls and bastions begin to crumple and collapse. Rogal Dorn, Praetorian of Terra, redoubles his efforts to keep the relentless enemy at bay, but his forces are vastly outnumbered and hopelessly outgunned. Dorn simply cannot defend everything. Any chance of survival now requires sacrifice, but what battles dare he lose so that others can be won? Is there one tactical stroke, one crucial combat, that could turn the tide forever and win the war outright? 

Across the length and breadth of the galaxy, humankind celebrates its salvation and relishes the prospect of a return to peace. But the war against the orks has driven the political bedrock of the Imperium, exposing its rotten core. One man, one powerful man, decides he has the solution and launches a campaign of destruction so terrible that thousands of years later his actions will still be viewed with horror.

In the centuries since his return from Commorragh, Fabius Bile has distanced himself from the affairs of friend and foe, content only to oversee the cruel evolution of his New Men. But when his creations are threatened by the monstrous haemonculi of the Thirteen Scars, the Manflayer is forced to seek out new allies and old enemies alike in an effort to preserve all that he has built. Homo Novus must survive...even if Fabius Bile must die to ensure it.   

As Guilliman, Regent of Terra, heads off to lead the Indomitus Crusade, he leaves behind a world still in turmoil, beset by cult activity. Stripped of its huge armies for the galactic offensive, recovery is precarious. The Custodians do what they can while keeping the Palace secure, and the Sisters of Silence rebuild their citadel on Luna. When the warship Phalanx returns, it seems that stability will at last be assured. However, as reconquest forces push out further into the slums, they come across signs that another mysterious foe is active.

Glory returns to Fenris. Magnus the Red and his traitorous legion are defeated upon the icy cliffs of the Space Wolves’ home world, their hollow remains scattered into the darkest depths of the World Sea. Yet Ragnar Blackmane, the youngest Wolf Lord in his Chapter’s noble history, does not feel victorious. He is uneasy. Uncertain of his purpose and place in the great war for the Imperium. Until a vision strikes him of a terrible beast, one greater than any he or his warriors have faced before. 

For a thousand years, the Sabbat Worlds have been lost to the Imperium, claimed by the dread powers of Chaos. Now, a mighty crusade seeks to return the sector to Imperial rule. And at the forefront of that crusade are Colonel-Commissar Ibram Gaunt and the Tanith First and Only - better known as Gaunt’s Ghosts. Trapped in the grinding trench warfare of Fortis Binary, the Ghosts find themselves drawn into a conspiracy to assassinate the crusade’s leader, Warmaster Macaroth.