Three generations of the Brown women travel west together on the Oregon Trail, but each seeks something different. When the trail divides, a decision must be made that could bring survival or tragedy. The challenges faced will form the character of one woman - and impact the future for many more.

In 1853, Abigail Scott was a 19-year-old school teacher in Oregon Territory when she married Ben Duniway. Marriage meant giving up on teaching, but Abigail always believed she was meant to be more than a good wife and mother. When financial mistakes and an injury force Ben to stop working, Abigail becomes the primary breadwinner for her growing family. What she sees as a working woman appalls her, and she devotes her life to fighting for the rights of women, including their right to vote.

Eliza Spalding Warren was just a child when she was taken hostage by the Cayuse Indians during a massacre in 1847. Now the young mother of two children, Eliza faces a different kind of dislocation; her impulsive husband wants them to make a new start in another territory, which will mean leaving her beloved home and her departed mother's grave - and returning to the land of her captivity.

Already well-versed in the natural healing properties of herbs and oils, Jennie Pickett longs to become a doctor. But the Oregon frontier of the 1870s doesn't approve of such innovations as women attending medical school. To leave grief and guilt behind, as well as support herself and her challenging young son, Jennie cares for an elderly woman using skills she's developed on her own. When her patient dies, Jennie discovers that her heart has become entangled with the woman's widowed husband, a man many years her senior.

During the fur-trapping era of the early 1800's, Marie Dorion refuses to be left behind in St. Louis when her husband heads west. Faced with hostile landscapes, an untried expedition leader, and her volatile husband, Marie finds that the daring act she hoped would bring her family together may, in the end, tear them apart. History records that on the journey, Marie may have briefly met Sacajawea, the famous interpreter who accompanied Lewis and Clark. She too was married to a mixed-blood man of French Canadian and Native American descent, and was raising a son in a white world.

It’s the summer of 1907, and the sun is scorching down on Mary Pearl in the Arizona Territory. Mary Pearl and her sister Esther take their minds off the heat by sneaking banned Jane Austen novels from Aunt Sarah Elliot’s lively bookshelf. Whispered read-alouds preoccupy their nights, and reveries of getting hitched to their own Mr. Darcy à la Pride and Prejudice swirl through their daydreams. In walks old-fashioned old-money suitor Aubrey Hanna, here to whisk 17-year-old Mary Pearl off her feet with a forbidden kiss and hasty engagement.

Cora Mae Stewart’s world collapses when Sherman destroys the Georgia cotton mill where she works and has her arrested for treason and sent North. Faced with impossible choices, she does what she must to keep a little girl safe in an inhospitable land. Convinced he won’t survive the war, Union Sergeant Ethan Howard determines to make his death count for something. But Cora Mae gives him a reason to live. Trouble is, he’s just arrested her on Sherman’s orders, and torn her from home and family.

When Laura McAllister, a young lady's maid, learns her three siblings have been taken from their mother and emigrated to Canada without her mother's knowledge, she becomes determined to search for them and reunite the family. But a lack of funds and resistance from authorities push her to use a false name and take a position with a child emigration society to gain passage to Canada. 

The Overland Trail, 1853: Naomi May never expected to be widowed at 20. Eager to leave her grief behind, she sets off with her family for a life out West. On the trail, she forms an instant connection with John Lowry, a half-Pawnee man straddling two worlds and a stranger in both. But life in a wagon train is fraught with hardship, fear, and death. Even as John and Naomi are drawn to each other, the trials of the journey and their disparate pasts work to keep them apart.

Emily Leland sheds no tears when her abusive husband is killed in a bar fight, but what awaits her back home in Sweetwater Crossing is far from the welcome and comfort she expected. First she discovers her father has died under mysterious circumstances. Then the house where the handsome new schoolteacher, Craig Ferguson, and his son are supposed to board burns, leaving them homeless. When Emily proposes turning the family home into a boardinghouse, her sister is so incensed that she leaves town.

August 18, 1862: On the Sioux reservation in southwestern Minnesota, Indians desperate for food and freedom rise up against whites in the region. Sarah Wakefield, the wife of a physician, is taken captive with her two babies. Their fate falls into the hands of the warrior Ćaske. As war rages, little does she know how entwined their lives will become.

Growing up on their hardscrabble farm in rural Kentucky, 15-year-old Albertina "Bertie" Winslow has learned a lot from her mama, Polly. She knows how to lance a boil, make a pie crust, butcher a pig, and tend to every chore that needs doing. What she doesn't know, but is forced to reckon with all too soon, is how to look after children as a mother should. When Polly succumbs to a long illness, Bertie takes on responsibility for her four younger siblings and their dissolute, unreliable daddy.  

Upon uncovering her tyrannical father’s malevolent plot to commit her to an asylum, Beth Rutledge fabricates a plan of her own. She will rescue her mother, who had already been sent to the asylum, and escape together on a wagon train heading west. Posing as sisters, Beth and her mother travel with the pioneers in hopes of making it to Idaho before the others start asking too many questions.

Born in West Africa in the mid-eighteenth century, Maryam Prescilla Grace—a.k.a “Momma Grace” will live a long, wondrous life marked by hardship, oppression, opportunity, and love. Though she will be “gifted” various names, her birth name is known to her alone. Over the course of 100-plus years, she survives capture, enslavement by several property owners, the Atlantic crossing when she is only eleven years of age, and a brief stint as a pirate’s ward, acting as both a spy and a translator.

Since they were children running barefoot about Toulouse Plantation, Josie and Cleo have been as close as sisters, forging an unbreakable bond that defies their roles as mistress and slave. Together, the two have shared secrets and protected each other through happiness and heartbreak. They never dream they could also share an intense passion for the same man, the elegant, charming, and irresistibly seductive Bertrand Chamard.