Midwife Patience Murphy has a gift: a talent for escorting mothers through the challenges of bringing children into the world. Working in the hardscrabble conditions of Appalachia during the Depression, Patience takes the jobs that no one else wants, helping those most in need - and least likely to pay. She knows a successful midwifery practice must be built on a foundation of openness and trust - but the secrets Patience is keeping are far too intimate and fragile for her to ever let anyone in.

Heather is pale and thin, seventeen and pregnant with twins when Patricia Harman begins to care for her. Over the course of the next five seasons Patsy will see Heather through the loss of both babies and their father. She will also care for her longtime patient Nila, pregnant for the eighth time and trying to make a new life without her abusive husband. And Patsy will try to find some comfort to offer Holly, whose teenage daughter struggles with bulimia. She will help Rebba learn to find pleasure in her body and help Kaz transition into a new body.

Three very different girls sign up as trainee nurses at a big London teaching hospital in 1934. Dora leaves her overcrowded, squalid working-class home for a better life. But has she got what it takes to keep up with other, better-educated girls? And will her hated stepfather ever let her go? Helen is born for the job; her brother is a doctor, her all-powerful mother a hospital trustee. But will Helen’s secret misery be her downfall? An aristocratic rebel, Millie’s carefree attitude will find her up in front of Matron again and again. Will she ever care enough to make a nurse? Or will she go back to the glamorous life she was born to?

Ana Kaminski is pushed through the iron gates of Auschwitz beside her frightened young friend Ester Pasternak. As they reach the front of the line, Ana steps forward and quietly declares herself a midwife--and Ester her assistant. Their arms are tattooed and they’re ordered to the maternity hut. Holding an innocent newborn baby, Ana knows the fate of so many are in her hands and vows to do everything she can to save them.

Midwife Kim Osterholzer ushers listeners behind the doors of Amish homes as she recounts her adventures answering God's call to the craft of midwifery. Kim chronicles her nine-year apprenticeship grappling with the nuances and idiosyncrasies of homebirth. She recounts the beauty and painstaking effort of those early years spent catching babies by the light of crackling woodstoves, oil lamps, and lanterns. Every birth enthralled her, whether it involved halting hemorrhages, sharing breath with tiny lungs, or bouncing through wild rides in ambulances.

When Sophie Weiss boards the SS St Louis, she has no reason to stay in Germany. The Nazis have taken everything from her, and her only hope is escape. But when she meets fellow Jewish refugees Rosa, Hannah and Rachel on board, the friendship they form gives Sophie hope that there can be happiness in her future, after all.

In the ruggedness of the beautiful Kentucky mountains, Honey Lovett has always known that the old ways can make a hard life harder. As the daughter of the famed blue-skinned Troublesome Creek packhorse librarian, Honey and her family have been hiding from the law all her life. But when her mother and father are imprisoned, Honey realizes she must fight to stay free, or risk being sent away for good.

Del Wensley, wife of the most celebrated preacher in Harlan County, tries to mind her place. Until her husband’s infidelity pushes an already strained marriage to a breaking point. Clinging to her last hope for self-respect, Del turns her back on the rigid life she’s known. A coal train is rolling through the valley. With her eyes wide open to the unfamiliar, and to the freedom she craves, Del takes to the rails.

Nestled in the hills of West Virginia lies White Sulphur Springs, home to the Greenbrier Resort. Long a playground for presidents and film stars, the Greenbrier has its own gravitational pull. Over ten decades, four generations of the Zelner family must grapple with their place in its shadow . . . and within their own family.

Superheroes have always been Leia Birch Briggs' weakness. One tequila-soaked night at a comics convention, the usually level-headed graphic novelist is swept off her barstool by a handsome and anonymous Batman. It turns out the caped crusader has left her with more than just a nice, fuzzy memory. She's having a baby boy - an unexpected but not unhappy development in the 38-year-old's life.

1945. The tiny bundle in her arms barely stirs as she hurries out into the dark street. Remembering Villa Teresa, a thousand miles away in sun-soaked Italy, Betty thinks of the letter she had to write to stop the bombing and save Gianni. Instead, it cost her everything, and she will never see her beloved again. Letting her little baby go will tear her apart, but she knows it is the only way to keep her child safe.

‘A second’s silence and then an almighty scream. It was the most moving thing I had ever seen … A baby, a real live baby, another human life had entered the world. It didn’t seem possible and yet I had witnessed it with my very own eyes.’ Born into a happy working-class North London family in the mid-twentieth century, Katie is determined to ‘do something’ with her life. Working in the impoverished East End in the 1950s, she meets the Sisters of St John the Divine – a community of nuns dedicated to nursing and midwifery.

Lucy Duff Gordon knows she is talented. She sees color, light, and texture in ways few people can begin to imagine. But is the male dominated world of haute couture, who would use her art for their own gain, ready for her? When she is deserted by her wealthy husband, Lucy is left penniless with an aging mother and her five-year-old daughter to support. Desperate to survive, Lucy turns to her one true talent to make a living. A

Occupied Poland, 1942: Despite the constant presence of German soldiers in her village, Emilia is allowed certain freedoms as a midwife—the most precious is innocently cycling past Nazi checkpoints to the homes of expectant mothers on her rounds. But Emilia has a secret: for years she’s also been visiting the hidden Jewish mothers and working for the resistance…until she is betrayed.

Life is hard for Ruby growing up in poverty on the wrong side of the mountain on her grandfather's farm where literally the sun didn’t shine. The Appalachian setting isn’t her friend as she searches for an easy life at the "tippy-top" with contentment and security. Ruby makes a series of bad decisions, causing her life to tumble into an unexpected outcome.