Worie Dressar is 17 years old when influenza and typhoid ravage her Appalachian Mountain community in 1877, leaving behind a growing number of orphaned children with no way to care for themselves. Worie’s mother has been secretly feeding several of these little ones on Sourwood Mountain. But when tragedy strikes, Worie is left to figure out why and how she was caring for them.

Bertie Jenkins has spent forty years serving as a midwife for her community in the Great Smoky Mountains of East Tennessee. Out of all the mothers she’s tended, none affects her more than the young teenager who shows up on her doorstep, injured, afraid, and expecting, one warm June day in 1943. As Bertie and her four sisters tenderly nurture Songbird back to health, the bond between the childless midwife and the motherless teen grows strong. But soon Songbird is forced to make a heartbreaking decision that will tear this little family apart.

Life is hard for Ruby growing up in poverty on the wrong side of the mountain on her grandfather's farm where literally the sun didn’t shine. The Appalachian setting isn’t her friend as she searches for an easy life at the "tippy-top" with contentment and security. Ruby makes a series of bad decisions, causing her life to tumble into an unexpected outcome.

In 1933 Louisville, Kentucky, even the ongoing economic depression cannot keep Piper Danson's parents from insisting on a debut party. After all, their fortune came through the market crash intact, and they've picked out the perfect suitor for their daughter. Braxton Crandall can give her the kind of life to which she's accustomed. The only problem? This is not the man - or the life - she really wants.   

In a North Carolina mountain town filled with moonshine and rotten husbands, Sadie Blue is only the latest girl to face a dead-end future at the mercy of a dangerous drunk. She's been married to Roy Tupkin for 15 days, and she knows now that she should have listened to the folks who said he was trouble. But when a stranger sweeps in and knocks the world off-kilter for everyone in town, Sadie begins to think there might be more to life than being Roy's wife.

Sixteen-year-old Lorena Leland’s dreams of a rich and fulfilling life as a writer are dashed when the stock market crashes in 1929. Seven years into the Great Depression, Rena’s banker father has retreated into the bottle, her sister is married to a lazy charlatan and gambler, and Rena is an unemployed newspaper reporter. Eager for any writing job, Rena accepts a position interviewing former slaves for the Federal Writers’ Project. There, she meets Frankie Washington, a 101-year-old woman whose honest yet tragic past captivates Rena.

Growing up on their hardscrabble farm in rural Kentucky, 15-year-old Albertina "Bertie" Winslow has learned a lot from her mama, Polly. She knows how to lance a boil, make a pie crust, butcher a pig, and tend to every chore that needs doing. What she doesn't know, but is forced to reckon with all too soon, is how to look after children as a mother should. When Polly succumbs to a long illness, Bertie takes on responsibility for her four younger siblings and their dissolute, unreliable daddy.  

For years, the town of Silver Bell, Arkansas has quietly mourned the hospital fire that claimed the lives of nine of its residents—the town doctor, a young expectant mother, and seven infants. So, when journalist Finn Hardwick is assigned the story as part of a national thirtieth anniversary memorial service, he arrives at the town ready to interview its residents, thinking they’ll be ready to share and eager to make headlines. He isn’t prepared for the resistance. Or for what appears to be a collective unwillingness to answer his questions.

Kentucky packhorse librarian Tansy Calhoun doesn't mind the rough trails and long hours as she serves her Appalachian mountain community during the Great Depression. Yet she longs to find love like the heroines in her books. When a charming writer comes to town, she thinks she might have found it - or is the perfect man actually closer than she thinks?

Orphaned in the cholera epidemic of 1833, Adria Starr was cared for by a slave named Louis, a man who stayed in Springfield, Kentucky, when anyone with means had fled. A man who passed up the opportunity to escape his bondage and instead tended to the sick and buried the dead. A man who, 12 years later, is being sold by his owners despite his heroic actions. Now 19, Adria has never forgotten what Louis did for her. She's determined to find a way to buy Louis's freedom. But in 1840s Kentucky, she'll face an uphill battle.

Teeny, Sonny Boy and Vic have been swallowed up by the desperation and devastation of the Great Depression, but the trio is buoyed by the fantastical tales Teeny weaves around campfires in hobo jungles and migrant camps, including the story of the raffle baby. As the three navigate the ravages of poverty and prejudices, they form a family bond as strong as the forces against them. But when a solemn pact fails to protect them, their lives are forever changed. And Sonny Boy is left to tell their story, and his own.

For twelve-year-old Martha "Sonny" Creech, there is no place more beautiful than her family's cotton farm. She, her two brothers, and her parents work hard on their land - hoeing, planting, picking - but only Sonny loves the rich, dark earth the way her father does. When a tragic accident claims his life, her stricken family struggles to fend off ruin - until their rich, reclusive neighbor offers to help finance that year's cotton crop.

Jericho Coulter, the eldest of six fiercely devoted brothers, is entrusted with safeguarding his family and the secret that binds them together: the Sapphire mine. To keep tragedy from striking again, he allows no outsiders on their land. When two women stumble upon their ranch, claiming Jericho himself sent for one of them as a mail-order bride, he aims to send them straight back where they came from.

The year is 1938 and a family in the small South Carolina town of Beaufort faces serious adversity. After the birth of her long awaited son, Mary Banks dives into a dark postpartum period, throwing her into a deep depression. Thinking that her sister, Rose, is offering her a helping hand, Mary leaves her family and goes to Boston in search of a medical cure, not to be heard from again.

A story of resilience and redemption set against one of America’s defining moments - the Dust Bowl.