Everyone in the small town of Denton is searching for Isabelle Coleman, a missing 17-year-old girl. All they've found so far is her phone and another girl they didn't even know was missing. Mute and completely unresponsive to the world around her, it's clear this mysterious girl has been damaged beyond repair. All Detective Josie Quinn can get from her is a name: Ramona. Currently suspended from the force for misconduct, Josie takes matters into her own hands as the name leads her to evidence linking the two girls.

During a vicious heat wave, a county maintenance worker stumbles upon two suspicious suitcases abandoned by the side of the road. Sheriff Bree Taggert responds to find two bodies stuffed inside the luggage. The press demands action. The community is on edge. Suddenly, Bree is at the center of a media firestorm. In Oregon, a senator’s daughter goes missing. FBI Special Agent Mercy Kilpatrick agrees to keep the politically sensitive case on the down-low.

When Jenna Bernstein, disgraced wunderkind CEO of a controversial biotech company, is accused of murdering her former partner and lover, she turns to Seattle attorney Keera Duggan to defend her. Keera is more than a master chess player who brings her intuitive moves into court—she’s Jenna’s childhood friend. But considering their history, Keera knows that where Jenna goes, trouble follows.

Alex Cross is a homicide detective with a PhD in psychology. He works and lives in the ghettos of D. C. and looks like Muhammad Ali in his prime. He's a tough guy from a tough part of town who wears Harris Tweed jackets and likes to relax by banging out Gershwin tunes on his baby grand piano. But he also has two adorable kids of his own, and they are his own special vulnerabilities. Jezzie Flanagan is the first woman ever to hold the highly sensitive job as supervisor of the Secret Service in Washington.

Detective Evan Bolton is gutted by his latest investigation. His friend and mentor, retired detective Rod McLeod, has been murdered, his body left in the trunk of a junkyard car. When McLeod’s daughter and grandson abruptly vanish, Evan knows it’s not a coincidence. Search and rescue canine specialist Rowan Wolff agrees as she and her dog, Thor, track the missing family.