Erik and Lara are in mourning for their daughter, who was born "incompatible with life". To get away from their suffocating grief and the ever-present shadow their daughter has cast in their lives since passing, and desperately trying to recover their increasingly rocky relationship, they take a trip to the seaside town of Polperro, in Cornwall. But no sooner have they arrived, than they realize that their grief cannot be so easily eluded. Drawn to the waters, Erik and Lara discover a large Devil's Pocketbook, and inside: the miracle child they could never have. Scylla.

Struggling with money, raising a child alone, and fleeing a volatile ex, Jess McMachen accepts a job caring for an elderly patient. Flo Gardner–a disturbed shut-in and invalid. But if Jess can hold this job down, she and her daughter, Izzy, can begin a new life. Flo's vast home, Nerthus House, may resemble a stately vicarage in an idyllic village, but the labyrinthine interior is a dark, cluttered warren filled with pagan artefacts.

Joe works at a facility that performs human experimentation. His work just followed him home. The government wanted to unlock hidden abilities in the human mind. They put subjects in extreme sensory deprivation. All the test subjects went violently insane. But the research continued. Today it has been perfected. Almost perfected. 

When Roger Huntington comes home from college for the summer and is met by his best friend, Tooth, he knows they're going to have a good time. A summer full of beer, comic books, movies, laughs, and maybe even girls. The sun is high and the sky is clear as Roger and Tooth set out to shoot beer cans at Bobcat Mountain. Just two friends catching up on lost time, two friends thinking about their futures. . . two friends suddenly thrust into the middle of a nightmare.

The Lonely Motel holds many dark secrets and room six just might hold the worst of them all. Angel knows a lot about pain. His mother died in this room. He's researched its history. He's come back today to end it, no matter the cost, once and for all. Prostitute Shyla believes the stories Angel tells her can't be true. Secrets so vile, you won't want to let them inside you. But the Lonely Motel doesn't forget. It doesn't forgive. And it always claims its victim.

With winter looming, a small northern Anishinaabe community goes dark. Cut off, people become passive and confused. Panic builds as the food supply dwindles. While the band council and a pocket of community members struggle to maintain order, an unexpected visitor arrives, escaping the crumbling society to the south. Soon after, others follow. Frustrated by the building chaos, a group of young friends and their families turn to the land and Anishinaabe tradition in hopes of helping their community thrive again.

Mike and Beth didn't know each other existed before the night of the meteor shower. A melancholy film producer and a house sitter barely scraping by—chance made them neighbors, a bottle of champagne brought them together, and a shared need for human connection sparked something more. After a drunken and desperate one-night stand, the two strangers awake to discover a surprise astronomical event has left widespread destruction in its wake. But the cosmic lightshow was only part of something much bigger, and far more terrifying.

Jodi was driving her children to college when The Man got in their car. Uninvited, unwanted, and unhinged. The Man has no name, but he does have a gun, a knife, and a bag of "toys". What starts as a forced ride into the desert escalates into a disturbing series of crimes and assaults.

Ben Stone is terrified. He's terrified because he weighs 601 pounds and needs his right leg amputating. He's terrified because a crane will shortly lift him from his fourth-floor flat and lower him 44 feet to an ambulance waiting below. He's terrified because he hasn't been outside in nine years, and he doesn't know who will look after his beautiful dog. He needn't worry, though, because the world is about to end.

Money's tight and their new home is a fixer-upper. Deep in rural South West England, with an ancient wood at the foot of the garden, Tom and his family are miles from anywhere and anyone familiar. His wife, Fiona, was never convinced that buying the money-pit at auction was a good idea. Not least because the previous owner committed suicide. Though no one can explain why.

Raised in a household so filthy it was stomach-spilling, Vera involuntarily evolved into a neat freak. Upon discovering she and her disabled husband, Daniel, are expecting, she needs fast cash. Her obsession with cleanliness sprouts the concept that her skills can be put to use in a unique way. She takes a stab at the booming door-to-door vacuum sales business of 1988. All is going well until she arrives at the steps of a house that will change her forever. The steps of an evil that resurrects the ghastly memories she so desperately tried to wash away. 

The Ruins follows two American couples enjoying a pleasant, lazy beach holiday together in Mexico. On an impulse, they go off with newfound friends in search of one of their group, the young German who, in pursuit of a girl, has headed for the remote Mayan ruins, site of a fabled archeological dig.

This forest isn't charted on any map. Every car breaks down at its treeline. Mina's is no different. Left stranded, she is forced into the dark woodland only to find a woman shouting, urging Mina to run to a concrete bunker. As the door slams behind her, the building is besieged by screams. Mina finds herself in a room with a wall of glass, and an electric light that activates at nightfall, when the watchers come above ground. These creatures emerge to observe their captive humans and terrible things happen to anyone who doesn't reach the bunker in time.

After the loss of a child along with a slew of agonizing misfortunes, Nick and Jess decide to end their lives. Unable to cope with the misery that fills their days, they commit one last act together and die in loving relief. But when Nick wakes up, he soon realizes that death isn't the gentle darkness he expected. Panicked and horrified, he struggles to understand the twisted abominations and hellish world he's now trapped in.

Alma Katsu calls My Heart Is a Chainsaw “a homage to slasher films that also manages to defy and transcend genre.” On the surface is a story of murder in small-town America. But beneath is its beating heart: a biting critique of American colonialism, Indigenous displacement, and gentrification, and a heartbreaking portrait of a broken young girl who uses horror movies to cope with the horror of her own life.