Liverpool, 1868. Shrouded in secrecy, Alice Sampson gives birth to a beautiful baby girl. But the former nurse's happiness is blighted by the knowledge that as a penniless, unwed mother, her future, and that of her child, can only be one of shame and disgrace. Then a knock at the door brings a miracle: she is invited to return to the Liverpool Royal Infirmary and her beloved ward. With the help of her friends and the welcome attentions of Reverend Seed, the hospital Chaplain, Alice slowly starts to rebuild her life. 

Liverpool, 1863. Maud Linklater's life as a housemaid changes forever the day she takes poor little injured chimney sweep Alfie to hospital. Helping to care for him on the ward, Maud is unexpectedly offered a place as a trainee at the newly opened nursing school run by Ada Houston. Maud loves her new role and throws herself wholeheartedly into the busy, exhausting experience of living and working at the hospital. And she has a lot of fun along the way once she befriends fellow trainees, including the sweet Alice and chatterbox Edie.   

Liverpool, 1855. Ada Houston is alone. Her grandfather has recently passed away, and her brother is missing, last seen working on the Liverpool docks. Everyone assumes him to be dead. But she will not give up hope. Ada's determined search takes her to the Crimea, where she joins the team of Florence Nightingale's nurses. She may have set off looking for her brother, but along the way Ada finds friends, romance and a new purpose in her own life in the most troubling and difficult of places.

1918, London. Twenty-year-old Emily Burdon has been training as a nurse at St. Marylebone Infirmary, learning on the job as she tends to patients from the crowded poorhouses that ring the hospital as well as wounded soldiers returning from the war. She pours her heart into her nursing while she waits for happier times - peace in Europe and the return of her childhood sweetheart, Lewis, from the Western Front. But when the deadly Spanish Flu arrives in London on the heels of the war, Emily’s faith and courage are put to the test. 

England, 1941. After three nights of relentless bombing from German aircraft, trained nurse Jo Brooks is told to report to the basement theater of Mill Road Hospital. She goes with a heavy heart, not wanting to leave behind her best friend Moira, who is desperately soothing new mothers on the maternity ward. As Jo arrives safely underground, the ward takes a direct hit. 

Nuneaton, 1911. When Holly Farthing's overbearing grandfather tries to force her to marry a dowdy widower twice her age she finally says no. When he refuses to support her any longer, Holly flees to London, bringing her best friend and maid, Ivy, with her. In the big smoke, Holly searches for the father she's never met and begins nurse training in the local hospital, where she meets the dashing Doctor Parkin. Kind and compassionate, he is everything that Holly has ever dreamt of. When Doctor Parkin proposes, Holly finally feels like she'll have the family she so longs for. 

It's the final year of training for three young nurses at The Nightingale Hospital. Helen is at a crossroads in her life as she battles with her domineering mother over both her love life and her future career. Dora can't stop loving Nick, who is married to her best friend, Ruby. Millie is anxious about her fiancé, sent to Spain to cover the Civil War, and things only get worse when she encounters a fortune teller who gives her a sinister warning.

Mary Vale, a grand and imposing Mother and Baby Home, sits on the remote Fylde coast in Lancashire. Its doors are open to unmarried women who come to hide their condition and find sanctuary. Women from all walks of life pass through Mary Vale, from beautiful waitress Emily, whose boyfriend has vanished without trace, to young Isla, cast out by her wealthy family after her first year at university goes horribly wrong. Awaiting them is Nurse Ada and Sister Anne who work tirelessly to aid the mothers and safely deliver the babies. 

It is June 1940, and as the bombs fall the women at home must dig deep. Tucked on the edge of the Lake District lies Mary Vale, a Mother and Baby Home open to unmarried women and their children. But tensions arise when three very different women walk through the doors.

Liverpool, 1939. Bella Rogers thought her life was just starting; she can’t wait to get married to her childhood sweetheart, Bobby. But when war is declared and Bobby is called up, his letters stop, leaving Bella heartbroken and alone. Then her family is torn apart by tragedy when her angelic 5-year-old sister dies from a terrible illness. They can barely afford a funeral, but the church is packed with the entire community, devastated for their loss. Grieving for her sister and lost love, Bella finds a job at the Bryant and May factory, making matches.

Anna is over the moon when her sweetheart returns from the front line. As he recovers from his injuries, they make plans to be married, but the horrors of the trenches cast a long shadow. Caring for shell-shocked soldiers brings untold challenges for Grace, and her parents have very different dreams for her future. Meanwhile Dulcie has her sights firmly set on her own happy ending. And yet sometimes we find love where we least expect to. Each of the nurses has her own battle to fight, but they must rally together if they’re to find true happiness.

London 1950. Peggy Ronoscki is happily settling into life running her guesthouse on Mulberry Lane, surrounded by close friends and family. Life just seems too good...but then disaster strikes. Pip, her beloved son, is left in a coma following a devastating car crash, and a young girl collapses in the market, leaving Peggy no option but to nurse her back to health. As things begin to go awry, Peggy worries she has brought trouble to her doorstep Can her life ever return to normal? Or has Peggy’s good nature led her astray?

Dora and her old enemy Lucy are paired up on the children's ward for the final three months of their training. The two nurses couldn't seem more different, but they may have more in common than they think, as each hides a secret heartache. And there are new faces. Jess is the feisty eldest daughter of a notorious East End family and determined to prove herself as a ward maid. New trainee nurse Effie can't wait to escape her small Irish village, and make her way as a nurse in London.

Liverpool, 1943. For Bella Rogers, life is looking up. She loves performing with The Bryant Sisters, the trio of singers who have become the country’s sweethearts, putting a smile on the faces of the brave boys fighting the Nazis. But then tragedy strikes when a telegram arrives: Bella’s beloved father has been killed in France. 

Three very different girls sign up as trainee nurses at a big London teaching hospital in 1934. Dora leaves her overcrowded, squalid working-class home for a better life. But has she got what it takes to keep up with other, better-educated girls? And will her hated stepfather ever let her go? Helen is born for the job; her brother is a doctor, her all-powerful mother a hospital trustee. But will Helen’s secret misery be her downfall? An aristocratic rebel, Millie’s carefree attitude will find her up in front of Matron again and again. Will she ever care enough to make a nurse? Or will she go back to the glamorous life she was born to?