Lee Nez is a nightwalker - a Navajo vampire. He's also a New Mexico state police officer. Paired with sexy FBI agent Diane Lopez, Lee is tracking down violent smugglers who have killed two cops while bringing silver and turquoise across the border from Mexico. Shocked to discover that the smugglers are Navajo shapeshifters/skinwalkers, Lee and Diane realize they must wipe out the whole pack, and fast, before the skinwalkers realize there's a nightwalker on their tails. Werewolves and vampires are deadly enemies.
Complicating matters, Lee is being stalked by a pair of vampire assassins. He killed the leader of their clan and the survivors are bent on revenge. Blood for blood, as the saying goes.