Days before her wedding, Julia Walsh is blindsided twice: once by the sudden death of her estranged father...and again when he appears on her doorstep after his funeral, ready to make amends, right his past mistakes, and prevent her from making new ones. Surprised, to say the least, Julia reluctantly agrees to turn what should have been her honeymoon into a spontaneous road trip with her father to make up for lost time.

In Massachusetts, neuroscience students Luke, Josh, and Hope have formed an unbreakable and unconditional friendship. Bound by their wit, brilliance, and curiosity, they throw themselves heart and soul into their research. Their new computer program can capture a person’s entire consciousness, memory, and personality - a digital map of the brain’s connections that promises to bridge the relationship between human and machine, between the past and the future. When Hope is diagnosed with a fatal and aggressive illness, their work takes on a new significance and urgency.

In 1960s Glasgow, anti-nuclear activists Judith and Jimmy fall in love. But their future hopes are dashed when their protestors’ squat is raided and many, including Jimmy, are sent to prison. Pregnant and with no word from Jimmy, Judith is forced to enter an unmarried mothers’ home, give up their baby and learn to live with her grief. 

Lewis Madigan is young, gay, out of work, and getting antsy when he’s roped into providing end-of-life care for his insufferable homophobic neighbor, Chester Wheeler. Lewis doesn’t need the aggravation, just the money. The only requirements: run errands, be on call, and put up with a miserable old churl no one else in Buffalo can bear. After exchanging barbs, bickering, baiting, and pushing buttons, Chester hits Lewis with the big ask. Lewis can’t say no to a dying wish.

After three disastrous marriages, a series of bad dates, and a tumultuous relationship with an emotionally abusive mother, psychology professor Nancy Jewel is through with love and commitment. Romantic or familial, the notion is a waste of her time. Content with being alone, she’s starting to feel normal-ish when she learns her father, incarcerated in Georgia, has been diagnosed with a terminal illness. 

Single mother Roxy Novak works days at a dentist’s office and delivers food at night, making the best life she can for herself and her son, Aero. When her wealthy ex-husband decides to ask for full custody, telling her Aero will be better off living with him and his Instagram-famous new wife, Roxy is stunned and scared. How can she possibly get the money to fight back? 

Mother of one and professional writer Saoirse is still adjusting to the demands of motherhood, four years after the birth of her daughter, Anna. Living in the claustrophobic London suburb of Woodvale, and being surrounded by passive-aggressive mum-wars, isn’t helping. Neither is her increasingly pent-up anger at her once-perfect husband. Her only comrade in arms, best friend Bea, is the one thing keeping her sane. When Saoirse’s agent asks her to pitch for a book, she is horrified to discover the topic is motherhood.

Amy Piper is a loser. She’s lost her confidence, her mojo and her way. But one thing she has never lost is her total love for her 13-year-old son, Joey, and for his sake she knows it’s time for a change. But first she has to be brave enough to leave the house. What she needs are friends and an adventure. And when she joins a running group of women who call themselves the Larks, she finds both. Not to mention their inspiring (and rather handsome) coach, Nathan.

On the big screen, Mia plays a woman in love. But in real life, she's an actress in need of a break from her real-life philandering husband - the megastar who plays her romantic interest in the movies. So she heads across the English Channel to hide in Paris behind a new haircut, fake eyeglasses, and a waitressing job at her best friend's restaurant.

Small, shy, safe. That’s how Becky lives ever since her last romantic calamity landed her in hospital. Her comfort zone is as confining as her tiny bank balance and fiercely guarded by her totally over-the-top mum. But the news that her ex is back sniffing round is the final straw. In a very un-Becky move, she packs her bags for the Greek island of Skiathos. When sizzling-hot restaurant-owner Kyros asks her to stay longer, Becky is stunned. Could she really create a new life for herself here and trust her heart with this smooth-talking charmer? 

When 82-year-old Lil decides to book herself, her 65-year-old daughter, Cassie, and her friend Maggie on a bus trip across Europe, she hopes for a little adventure to counteract the monotony of life. Along with three members of the Salterley Tennis Club and the Jolly Weaver football team, whose ideas of a good time are rather different to Lil’s and strikingly at odds with each other’s, the merry band of travellers set out on their great adventure.

They’re coworkers, friends, and confidants, but Peter Marshal has always pined for a little something more with Noelle Walters. As a widow and a single mom, Noelle prefers to play it safe, and falling for Peter was never part of the plan. Then again, neither of their plans accounted for the well-meaning but meddling actions of Peter’s sister, who offers him up as their town’s most eligible bachelor in the local moms’ Facebook group. He’s none the wiser about the source of this sudden surge in attention, but he only has eyes for Noelle.

Life is about to get complicated for Amelia Montgomery, a prominent litigator in Chicago. She’s been fired for not compromising her principles in a high-profile case and then punching her partner in the nose for the misogynistic comment he made in retort (not her finest moment). Leaving a career that gave her purpose, Amelia can only ask, What next? Let it be better than her epic failure of a fortieth birthday party: an open bar full of no-shows except for John Ellis, a total stranger and the new associate at her ex-firm. 

When Ruby Lamont’s young son Jake starts telling tall tales about the dad who walked out on them six years ago, it’s time to find out the truth. It’s not that she wants Kenny back in her life—her charming commitment-phobe Griffin, has always been more of a father-figure to Jake—but if she can understand why Kenny broke her heart, perhaps she can finally move on.

It’s been two years and two months since trauma shattered hospital chaplain Isabel Myles’s world. Since that day, she has stopped answering calls. She’s shut out her family, friends, and coworkers. Even her faith seems to have faded. Except for her connection with her younger sister, Chantel, Isabel copes by forgetting. Then she takes on a summer job as a home caregiver for Opal, a dementia patient who is struggling to remember.