Matthew Bartholomew, doctor of medicine and fellow of Michaelhouse, Cambridge, is travelling with a party from the college to accept the gift of the living of a parish in Suffolk. One of his companions, Unwin, an unworldly scholar, is to be installed as priest. Their journey is not without incident - they are chased by footpads, pass through an eerie village abandoned after the recent plague and find a man barely alive on a gibbet - so they reach their destination with some relief. But their thoughts of recovering while enjoying the local Pentecostal Fair are soon curtailed.

Cambridge in 1352 is rife with terrible clashes between the fledgling university and the townspeople. Matthew Bartholomew, physician and teacher at Michaelhouse College, is trying to keep the peace when a student is murdered and the town plunges into chaos. At the same time, a skeleton is discovered that is rumoured to belong to a local martyr, and Bartholomew has his hands full investigating both deaths while the rioting intensifies....

Michaelhouse is in uproar: Kenyngham, the saintly but ageing master, has announced his retirement, and with unseemly haste Runham arranges his own 'election' as his successor. Within days he has dismissed several members of staff, including the redoubtable laundress Agatha, and is making life so unpleasant for the scholars that even Matthew Bartholomew believes his future as physician and teacher at the college is untenable.

In 1350 the people of Cambridge are struggling to overcome the effects of the Black Death - and with a high mortality rate among priests and monks, the townsfolk are vulnerable to sinister cults that have sprung up. At Michaelhouse, Matthew Bartholomew is training new physicians when the body of a friar is found in the massive chest that the university uses to store precious documents. While investigating, Bartholomew stumbles across a derelict church being used as a meeting place for the mysterious sect he believes is at the heart of a web of blackmail.

Matthew Bartholomew, unorthodox but effective physician to Michaelhouse college in medieval Cambridge, is as worried as anyone about the pestilence that is ravaging Europe and seems to be approaching England. But he is distracted by the sudden and inexplicable death of the Master of Michaelhouse - a death the University authorities do not want investigated.

Matthew Bartholomew jumps at the chance to travel to Ely with Brother Michael, as it will give him a unique opportunity to study in the richly stocked library of the Benedictine priory. Michael has been summoned to the city by his bishop, but it isn't until they arrive that they discover the reason - the bishop has been accused of murder. The charge seems ludicrous, but Michael takes the investigation seriously and energetically sets about his task. Almost immediately he discovers that there appears to have been a series of unexplained deaths in the area.

In Cambridge, 1355, the colleges of the fledgling university are as much at odds with each other as they are with the ordinary townfolk. This tension has recently been heightened by the return of two well-born murderers after receiving the King's pardon, showing no remorse but ready to confront those who helped convict them. And in the midst of this Bartholomew the physician is called to the local mill to examine two corpses. It is almost a relief to be able to turn his back on the fractious town, but as always in Cambridge nothing is disconnected.

Cambridge, 1354. Christmas approaches, and the town is gripped by the worst blizzards in living memory. As the physician Matthew Bartholomew struggles to help the poorer citizens cope with freezing temperatures, his colleagues prepare for the festivities. The weather has trapped many travellers in the town, including Matthew's erstwhile love, Philippa. She and her wealthy husband are invited to Michaelhouse for the main feast, and Matthew is horrified that he does not immediately recognise the overweight, sulky woman who once stole his heart.

February 1355: Oxford explodes in one of the most serious riots of its history. Fearing for their lives, the scholars flee, and some choose the University at Cambridge as their temporary refuge. But they don't remain safe for long. Within hours of their arrival, the first of their number dies, followed quickly by a second. When Matthew Bartholomew begins to investigate the deaths, he uncovers evidence that the Oxford riot was not a case of random violence, but part of a carefully orchestrated plot.

It is not long before they learn that the friary in which they are staying is not the safe haven they imagine - one guest has already been murdered. It soon emerges that the dead man was holding the Hugh Chalice, a Lincoln relic with a curiously bloody history. Bartholomew and Michael are soon drawn into a web of murder, lies and suspicion in a city where neither knows who can be trusted.

There is something very amiss in the finances of Michaelhouse. Despite a new influx of well-heeled students, there is an acute lack of funds for the upkeep of the buildings, even for decent provisions. It is only when the brother in charge of the account books dies unexpectedly that some sort of explanation is revealed: he has been paying large amounts of money for goods the college itself has never received.

When a wealthy benefactor is found dead in Michaelhouse, Brother Michael and Matthew Bartholomew must find the culprit before the college is accused of foul play. At the same time, Cambridge is plagued by a mystery thief who is targeting rich pilgrims. Moreover, pranksters are at large in the university, staging a series of practical jokes that are growing increasingly dangerous and that are dividing scholars into bitterly opposed factions.

Cambridge University is in dire financial straits: the town's landlords are demanding an extortionate rent rise for the students' hostels, and the plague years have left the colleges with scant resources. Tension between town and gown is at boiling point and soon explodes into violence and death. Into this maelstrom comes a charismatic physician whose healing methods owe more to magic than medicine, but his success threatens Matthew Bartholomew's professional reputation - and his life....

Matthew Bartholomew doesn't want to travel to Peterborough in the summer of 1358, but his friendship with the lovely Julitta Holm has caused a scandal in Cambridge, so he has no choice. He is one of a party of Bishop's Commissioners, charged to discover what happened to Peterborough's abbot, who went for a ride one day and has not been seen since. When the Commissioners arrive, they find the town in turmoil.

In the summer of 1358 the physician Matthew Bartholomew returns to Cambridge to learn that his beloved sister is in mourning after the unexpected death of her husband, Oswald Stanmore. Aware that his son has no interest in the cloth trade that made his fortune and reputation, Oswald has left the business to his widow, but a spate of burglaries in the town distracts Matthew from supporting Edith in her grief and attempting to keep the peace between her and her wayward son.