In Cambridge, 1355, the colleges of the fledgling university are as much at odds with each other as they are with the ordinary townfolk. This tension has recently been heightened by the return of two well-born murderers after receiving the King's pardon, showing no remorse but ready to confront those who helped convict them. And in the midst of this Bartholomew the physician is called to the local mill to examine two corpses. It is almost a relief to be able to turn his back on the fractious town, but as always in Cambridge nothing is disconnected.

Cambridge University is in dire financial straits: the town's landlords are demanding an extortionate rent rise for the students' hostels, and the plague years have left the colleges with scant resources. Tension between town and gown is at boiling point and soon explodes into violence and death. Into this maelstrom comes a charismatic physician whose healing methods owe more to magic than medicine, but his success threatens Matthew Bartholomew's professional reputation - and his life....

It is not long before they learn that the friary in which they are staying is not the safe haven they imagine - one guest has already been murdered. It soon emerges that the dead man was holding the Hugh Chalice, a Lincoln relic with a curiously bloody history. Bartholomew and Michael are soon drawn into a web of murder, lies and suspicion in a city where neither knows who can be trusted.

Cambridge, 1354. Christmas approaches, and the town is gripped by the worst blizzards in living memory. As the physician Matthew Bartholomew struggles to help the poorer citizens cope with freezing temperatures, his colleagues prepare for the festivities. The weather has trapped many travellers in the town, including Matthew's erstwhile love, Philippa. She and her wealthy husband are invited to Michaelhouse for the main feast, and Matthew is horrified that he does not immediately recognise the overweight, sulky woman who once stole his heart.

Matthew Bartholomew jumps at the chance to travel to Ely with Brother Michael, as it will give him a unique opportunity to study in the richly stocked library of the Benedictine priory. Michael has been summoned to the city by his bishop, but it isn't until they arrive that they discover the reason - the bishop has been accused of murder. The charge seems ludicrous, but Michael takes the investigation seriously and energetically sets about his task. Almost immediately he discovers that there appears to have been a series of unexplained deaths in the area.

Rumours of plague threaten Cambridge again, 10 years after the Black Death had almost laid waste to the town. Neither the church nor its priests had defended people from the disease, and now they turn elsewhere for protection, to pagan ritual and magical potions. It is a ripe atmosphere to be exploited by the mysterious 'Sorcerer', an anonymous magician whose increasing influence seems certain to oust both civil and church leaders from power.

When a wealthy benefactor is found dead in Michaelhouse, Brother Michael and Matthew Bartholomew must find the culprit before the college is accused of foul play. At the same time, Cambridge is plagued by a mystery thief who is targeting rich pilgrims. Moreover, pranksters are at large in the university, staging a series of practical jokes that are growing increasingly dangerous and that are dividing scholars into bitterly opposed factions.

It is drawing near to the end of term, and the University at Cambridge is in turmoil over the opening of a new common library. There is an attack on one of the masters at a meeting to discuss the matter, and a body is found floating in the pond in the library's garden on the eve of its opening. Meanwhile, there are rumours of a large force of dangerous smugglers lurking in the Fens. Aided by their friend Sheriff Tulyet, Bartholomew and Michael must thwart the invaders before the Feast of Corpus Christi the following week.

Michaelhouse is in uproar: Kenyngham, the saintly but ageing master, has announced his retirement, and with unseemly haste Runham arranges his own 'election' as his successor. Within days he has dismissed several members of staff, including the redoubtable laundress Agatha, and is making life so unpleasant for the scholars that even Matthew Bartholomew believes his future as physician and teacher at the college is untenable.

In 1360 Edward III issues a call to arms, as sporadic attacks by the French threaten to turn into a full-blown invasion. In Cambridge, fear of the enemy is magnified by the belief that foreign agents are lurking in the area. Tension runs ever higher as rumours and ignorance fan the flames of suspicion amid preparations for war. And then the first murder occurs - of a French scholar living in the town.

In 1358 the fledging college of Michaelhouse in Cambridge is in need of extra funds. A legacy from the Archbishop of York of a parish close to that city promises a welcome source of income. However, there has been another claim to its ownership, and it seems the only way to settle the dispute is for a deputation from Michaelhouse to travel north. Matthew Bartholomew is among the small party which arrives in the bustling city, where the increasing wealth of the merchants is unsettling the established order....

Matthew Bartholomew, doctor of medicine and fellow of Michaelhouse, Cambridge, is travelling with a party from the college to accept the gift of the living of a parish in Suffolk. One of his companions, Unwin, an unworldly scholar, is to be installed as priest. Their journey is not without incident - they are chased by footpads, pass through an eerie village abandoned after the recent plague and find a man barely alive on a gibbet - so they reach their destination with some relief. But their thoughts of recovering while enjoying the local Pentecostal Fair are soon curtailed.

Identifying the murderer of the Chancellor of the university is not the only challenge facing physician Matthew Bartholomew. Many of his patients have been made worse by the ministrations of a 'surgeon' recently arrived from Nottingham, his sister is being rooked by the mason she has commissioned to build her husband's tomb and his friend, Brother Michael, has been offered a bishopric which will cause him to leave Cambridge.

The fourth chronicle of Matthew Bartholomew continues the adventures of the 14th-century Cambridge physician when he is called to attend to two deaths from some poisoned wine. The opening of a new and very well-endowed college has created petty infighting amongst the academics as new appointments are made. The winter and spring have been appallingly wet, there is a fever outbreak amongst the poorer townspeople and the country is not yet fully recovered from the aftermath of the plague.

Matthew Bartholomew doesn't want to travel to Peterborough in the summer of 1358, but his friendship with the lovely Julitta Holm has caused a scandal in Cambridge, so he has no choice. He is one of a party of Bishop's Commissioners, charged to discover what happened to Peterborough's abbot, who went for a ride one day and has not been seen since. When the Commissioners arrive, they find the town in turmoil.