It is not long before they learn that the friary in which they are staying is not the safe haven they imagine - one guest has already been murdered. It soon emerges that the dead man was holding the Hugh Chalice, a Lincoln relic with a curiously bloody history. Bartholomew and Michael are soon drawn into a web of murder, lies and suspicion in a city where neither knows who can be trusted.

In Cambridge, 1355, the colleges of the fledgling university are as much at odds with each other as they are with the ordinary townfolk. This tension has recently been heightened by the return of two well-born murderers after receiving the King's pardon, showing no remorse but ready to confront those who helped convict them. And in the midst of this Bartholomew the physician is called to the local mill to examine two corpses. It is almost a relief to be able to turn his back on the fractious town, but as always in Cambridge nothing is disconnected.

Cambridge University is in dire financial straits: the town's landlords are demanding an extortionate rent rise for the students' hostels, and the plague years have left the colleges with scant resources. Tension between town and gown is at boiling point and soon explodes into violence and death. Into this maelstrom comes a charismatic physician whose healing methods owe more to magic than medicine, but his success threatens Matthew Bartholomew's professional reputation - and his life....

Cambridge, 1354. Christmas approaches, and the town is gripped by the worst blizzards in living memory. As the physician Matthew Bartholomew struggles to help the poorer citizens cope with freezing temperatures, his colleagues prepare for the festivities. The weather has trapped many travellers in the town, including Matthew's erstwhile love, Philippa. She and her wealthy husband are invited to Michaelhouse for the main feast, and Matthew is horrified that he does not immediately recognise the overweight, sulky woman who once stole his heart.

Rumours of plague threaten Cambridge again, 10 years after the Black Death had almost laid waste to the town. Neither the church nor its priests had defended people from the disease, and now they turn elsewhere for protection, to pagan ritual and magical potions. It is a ripe atmosphere to be exploited by the mysterious 'Sorcerer', an anonymous magician whose increasing influence seems certain to oust both civil and church leaders from power.

There is something very amiss in the finances of Michaelhouse. Despite a new influx of well-heeled students, there is an acute lack of funds for the upkeep of the buildings, even for decent provisions. It is only when the brother in charge of the account books dies unexpectedly that some sort of explanation is revealed: he has been paying large amounts of money for goods the college itself has never received.

Matthew Bartholomew jumps at the chance to travel to Ely with Brother Michael, as it will give him a unique opportunity to study in the richly stocked library of the Benedictine priory. Michael has been summoned to the city by his bishop, but it isn't until they arrive that they discover the reason - the bishop has been accused of murder. The charge seems ludicrous, but Michael takes the investigation seriously and energetically sets about his task. Almost immediately he discovers that there appears to have been a series of unexplained deaths in the area.

When a wealthy benefactor is found dead in Michaelhouse, Brother Michael and Matthew Bartholomew must find the culprit before the college is accused of foul play. At the same time, Cambridge is plagued by a mystery thief who is targeting rich pilgrims. Moreover, pranksters are at large in the university, staging a series of practical jokes that are growing increasingly dangerous and that are dividing scholars into bitterly opposed factions.

It is drawing near to the end of term, and the University at Cambridge is in turmoil over the opening of a new common library. There is an attack on one of the masters at a meeting to discuss the matter, and a body is found floating in the pond in the library's garden on the eve of its opening. Meanwhile, there are rumours of a large force of dangerous smugglers lurking in the Fens. Aided by their friend Sheriff Tulyet, Bartholomew and Michael must thwart the invaders before the Feast of Corpus Christi the following week.

In 1358 the fledging college of Michaelhouse in Cambridge is in need of extra funds. A legacy from the Archbishop of York of a parish close to that city promises a welcome source of income. However, there has been another claim to its ownership, and it seems the only way to settle the dispute is for a deputation from Michaelhouse to travel north. Matthew Bartholomew is among the small party which arrives in the bustling city, where the increasing wealth of the merchants is unsettling the established order....

In the summer of 1358 the physician Matthew Bartholomew returns to Cambridge to learn that his beloved sister is in mourning after the unexpected death of her husband, Oswald Stanmore. Aware that his son has no interest in the cloth trade that made his fortune and reputation, Oswald has left the business to his widow, but a spate of burglaries in the town distracts Matthew from supporting Edith in her grief and attempting to keep the peace between her and her wayward son.

In 1358, over a century after its foundation in Cambridge, the college of Michael House is facing a serious shortfall of funds and competition from upstarts rivals such as Zachary Hostel. Their problems are made no easier by the hostility of the town's inhabitants, who favour the university moving away to the Fens. This simmering tension threatens to break into violence when a well-known tradesman is found dead in one of the colleges.

Identifying the murderer of the Chancellor of the university is not the only challenge facing physician Matthew Bartholomew. Many of his patients have been made worse by the ministrations of a 'surgeon' recently arrived from Nottingham, his sister is being rooked by the mason she has commissioned to build her husband's tomb and his friend, Brother Michael, has been offered a bishopric which will cause him to leave Cambridge.

Michaelhouse is in uproar: Kenyngham, the saintly but ageing master, has announced his retirement, and with unseemly haste Runham arranges his own 'election' as his successor. Within days he has dismissed several members of staff, including the redoubtable laundress Agatha, and is making life so unpleasant for the scholars that even Matthew Bartholomew believes his future as physician and teacher at the college is untenable.

In 1360 a deputation from Cambridge ventures to the Suffolk town of Clare in the hope that the wealthy Elizabeth de Burgh has left a legacy to Michaelhouse. Yet when they arrive, they discover that the report of her death is false and that the college seems destined for bankruptcy. Determined to see if some of its well-heeled citizens can be persuaded to sponsor Michaelhouse, Matthew Bartholomew, Brother Michael and Master Langelee become enmeshed in the town's politics.