When nuclear waste is stolen by jihadists in the middle of the night from an unguarded New York City hospital, the police, in a frantic race against time, call in the FBI. Luke Stone, head of an elite, secretive department within the FBI, is the only man they can turn to. Luke realizes right away that the terrorists' aim is to create a dirty bomb, that they seek a high-value target, and that they will hit it within 48 hours.
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A biological agent is stolen from a biocontainment lab. Weaponized, it could kill millions, and a desperate national hunt ensues to catch the terrorists before it is too late. Luke Stone, head of an elite FBI department, with his own family still in jeopardy, has vowed to walk away - but when the new president, barely sworn in, calls him, he can't turn his back on her. Shocking devastation follows, winding its way all the way to the president, who finds her own family in jeopardy.
A cyberattack on an obscure US dam leaves thousands dead and the government wondering who attacked it, and why. When they realize it is just the tip of the iceberg - and that the safety of all of America is at stake - the president has no choice but to call in Luke Stone.