• Urticarial Vasculitis, Part 2: Walking the Balance Beam of Allergy and Rheumatology

  • Apr 18 2024
  • Length: 36 mins
  • Podcast
Urticarial Vasculitis, Part 2: Walking the Balance Beam of Allergy and Rheumatology cover art

Urticarial Vasculitis, Part 2: Walking the Balance Beam of Allergy and Rheumatology

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  • Summary

  • This episode digs into the pathophysiology of urticaria vasculitis from anti-C1q to the story of bradykinin.

    · Intro 0:11

    · In this episode 0:22

    · Review of episode 83 1:23

    · Listen to previous episode, The Complement System for Dunces 4:09

    · Anti-C1q antibodies 6:26

    · Lupus, anti-C1q and lupus nephritis 9:33

    · What happens when you inject anti-C1q in a mouse? 12:56

    · The allergy component: anti-C1q, urticaria and angioedema 17:36

    · Bradykinin-mediated angioedema and C1q deficiency 24:20

    · What is the kinin kallikrein system? 26:21

    · French researchers in 1909: human urine injected in dogs 27:30

    · How is this relevant to urticarial vasculitis? 31:08

    · SERPING1 gene mutation 31:23

    · Summary 32:06

    · COPD association with urticarial vasculitis 33:51

    · Coming up in episode 85 35:28

    · Thanks for listening 35:45

    Disclosures: Brown reports no relevant financial disclosures.

    We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

    References:

    Busse P, et al. J Allergy Clin Immunol Pract. 2022;doi:10.1016/j.jaip.2021.11.011.

    Davis MDP, et al. J Allergy Clin Immunol Pract. 2018;doi:10.1016/j.jaip.2018.05.006.

    Dorn JM, et al. Ann Allergy Asthma Immunol. 2023;doi:10.1016/j.anai.2023.06.014.

    Marzano AV, et al. J Allergy Clin Immunol. 2022;doi:10.1016/j.jaci.2022.02.007.

    Siegert CE, et al. Clin Immunol Immunopathol. 1993;doi:10.1006/clin.1993.1066.

    Stojan G, et al. Lupus. 2016;doi:10.1177/0961203316645205.

    Venzor J, et al. Clin Rev Allergy Immunol. 2002;doi:10.1385/CRIAI:23:2:201.

    Wisnieski JJ, et al. Medicine. 1995;doi:10.1097/00005792-199501000-00003.
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