On December 9, 2001, the bloody body of Kathleen Peterson was found dead at the bottom of the stairs in the North Carolina home she shared with her husband and novelist Michael Peterson. Blood-splattered evidence and a missing fireplace poker suggested it was a cold-blooded murder. Within two years, Michael Peterson was convicted of first-degree murder and sentenced to life in prison. But because a key witness, a blood-splatter expert, in fact, whose testimony was discredited, Michael Peterson's conviction was overturned.

On February 13, 2017, two Indiana teenagers, Abigail Williams, 13, and Liberty German, 14, went for a walk in the woods near the abandoned Monon High Bridge. They never returned home.

On Christmas Night 1996, six-year-old JonBenet Ramsey was murdered in her family's home in Boulder, Colorado. A ransom note was found, but it was hours before her father, John, found her body in the basement. She had been strangled with a garrote and her skull was fractured. The media sensationalized the tragic death of the "child beauty queen" and public speculation and rumors ran rampant. What followed was one of the most notorious unsolved murder investigations in American history.

Years before the name Alex Murdaugh was splashed across every major media outlet in America, local South Carolina journalist Mandy Matney had an instinct that something wasn’t right in the Lowcountry. The powerful Murdaugh dynasty had dominated rural South Carolina for generations. No one dared to cross them.

Two days after Christmas, 2011, Russel Faria returned to his Troy, Missouri, home to find his wife, Betsy, dead, a knife still lodged in her neck. She had been stabbed 55 times in a brutal murder that would set off a chain of events leading to one man's wrongful conviction and imprisonment, another man's death, the revelation of a diabolical scheme, and an astounding miscarriage of justice left unresolved for another 10 years.