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This episode is hosted by Pablo Perel, Senior Science Advisor at the World Heart Federation. He is joined by Dr. Jilliane Code, researcher, educator and heart transplant recipient, and Dr. Vagner Madrini Junior, cardiologist and Deputy Editor of Global Heart Journal.

Together, they explore heart failure from both the lived experience and clinical perspective. Dr. Code shares her powerful journey—from initial misdiagnosis in her twenties to advanced heart failure, transplantation, and long-term recovery—highlighting the emotional impact of hearing the words “heart failure,” the challenges of navigating complex treatment pathways, and the importance of patient empowerment.

Dr. Madrini Junior explains in accessible terms what heart failure is, its most common causes and symptoms, why diagnosis can be challenging, and how medication adherence and clear communication between healthcare professionals and patients are essential to improving outcomes.

Their conversation underscores the importance of listening to patients, addressing communication barriers, and fostering a multidisciplinary approach to care. Above all, it offers reassurance that with education, support, and partnership, people living with heart failure can lead meaningful and fulfilling lives.

Resources mentioned in this episode:

Scientific publication (PubMed):
https://pubmed.ncbi.nlm.nih.gov/41032214/

Blog – Heart Failure to Harvard:
https://heartfailuretoharvard.com

Documentary – My Broken Heart:
https://www.youtube.com/watch?v=yF7Pv7EZ308&t=308s

HeartLife Academy:
https://heartlife.academy

HeartLife:
https://heartlife.com

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World Heart Federation host Shreya Shrikhande speaks with Mike Lane from the Amyloidosis Army and David Gregory from the Amyloidosis Alliance on their powerful journeys with ATTR-CM.

They share the challenges of misdiagnosis, treatment access, community support, and the urgent need for awareness and early detection of transthyretin amyloid cardiomyopathy.

Find out more about Transthyretin Amyloid Cardiomyopathy ATTR-CM on World Heart Federation website.

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Host Pablo Perel and co-host Prof. Raul Santos talk with Dr Jiao Luo about Mendelian randomisation (MR) in cardiovascular research, what it is, core assumptions (relevance, independence, no horizontal pleiotropy), common pitfalls (weak instruments, population mismatch, non-linearity), and how to read MR papers.

The episode references:

Unraveling the Causal Links Between Immune Cells, Lipids, and Cardiovascular Diseases: Insights from Mendelian Randomization and

Mendelian Randomisation: Concepts, Opportunities, Challenges, and Future Directions.