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World Heart Federation host Shreya Shrikhande speaks with Mike Lane from the Amyloidosis Army and David Gregory from the Amyloidosis Alliance on their powerful journeys with ATTR-CM.

They share the challenges of misdiagnosis, treatment access, community support, and the urgent need for awareness and early detection of transthyretin amyloid cardiomyopathy.

Find out more about Transthyretin Amyloid Cardiomyopathy ATTR-CM on World Heart Federation website.

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Host Pablo Perel and co-host Prof. Raul Santos talk with Dr Jiao Luo about Mendelian randomisation (MR) in cardiovascular research, what it is, core assumptions (relevance, independence, no horizontal pleiotropy), common pitfalls (weak instruments, population mismatch, non-linearity), and how to read MR papers.

The episode references:

Unraveling the Causal Links Between Immune Cells, Lipids, and Cardiovascular Diseases: Insights from Mendelian Randomization and

Mendelian Randomisation: Concepts, Opportunities, Challenges, and Future Directions.

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In this episode, host Pablo Perel speaks with Mr. Girma Dessie and Dr. Andrew Moran about a powerful example of real-world cardiovascular implementation research from Ethiopia.

Mr. Dessie presents a recent study investigating why patients enrolled in a hypertension program were missing follow-up visits, despite strong program support and a standardized care model. The discussion covers the challenges of conducting field research in low-resource settings, particularly during the COVID-19 pandemic and civil unrest—and how their findings directly informed national health policy changes in Ethiopia.

Dr. Moran, co-author of the study and deputy editor of Global Heart, introduces the journal’s new section “Lessons from the Field,” aimed at amplifying implementation and operational research from low- and middle-income countries. He explains how this new platform will support practitioners and policymakers by bringing visibility to local innovations that improve cardiovascular care.

Tune in to learn how frontline research can drive evidence-based policy, improve retention in care, and shape global cardiovascular health strategies.

Read the featured paper in Global Heart:
Factors Associated with Hypertension Care Follow-Up in the Ethiopia HEARTS Program