Last week, some of the most forward-thinking minds in tech, culture, and politics came together for WIRED’s Big Interview event — a series of live, in-depth conversations with industry leaders. To kick off the event, Lauren sat down with AMD’s CEO Lisa Su. In today’s episode, Mike and Lauren sit down to discuss the key ideas that came up during the interview, as well as the other conversations that caught everyone’s attention during the event.

Articles mentioned in this episode:

• AMD CEO Lisa Su Says Concerns About an AI Bubble Are Overblown | WIRED
• Can AI Look at Your Retina and Diagnose Alzheimer’s? Eric Topol Hopes So | WIRED
• San Francisco Mayor Daniel Lurie: ‘We Are a City on the Rise’ | WIRED
• Watch the Highlights From WIRED’s 2025 Big Interview Event Right Here | WIRED

Join WIRED’s best and brightest on Uncanny Valley as they dissect the collision of tech, politics, finance, and business, from Alexis Ohanian's newest tech venture to the effects of inaccurate information from artificial intelligence (AI) chatbots on social protests.

Since taking office, San Francisco’s mayor has been on a quest to revitalize the city and increase public safety. He’s also kept the National Guard out—with a little help from some very powerful friends. Katie sat down with Mayor Lurie (who took off his shoes) on stage at WIRED’s Big Interview Event in San Francisco.

Join WIRED’s best and brightest on Uncanny Valley as they dissect the collision of tech, politics, finance, and business, from Alexis Ohanian's newest tech venture to the effects of inaccurate information from artificial intelligence (AI) chatbots on social protests.

In today’s episode, Zoë is joined by WIRED’s Leah Feiger to discuss five stories you need to know about this week — from how Amazon is trying to catch up in the AI race, to why Facebook Dating is more popular than ever. Then, they dive into how despite recent reports claiming that DOGE is over, its operatives are still working across federal agencies.

Articles mentioned in this episode:

• Amazon Has New Frontier AI Models—and a Way for Customers to Build Their Own | WIRED
• Poems Can Trick AI Into Helping You Make a Nuclear Weapon | WIRED
• Who the Hell Is Actually Using Facebook Dating? | WIRED
• Sex Workers Built an ‘Anti-OnlyFans’ to Take Control of Their Profits | WIRED
• DOGE Isn’t Dead. Here’s What Its Operatives Are Doing Now | WIRED

Join WIRED’s best and brightest on Uncanny Valley as they dissect the collision of tech, politics, finance, and business, from Alexis Ohanian's newest tech venture to the effects of inaccurate information from artificial intelligence (AI) chatbots on social protests.