Between 2007 and 2009, Anthony Sowell was linked to the deaths of 11 women whose bodies were discovered in and around his Cleveland home. Known as “The Cleveland Strangler,” Sowell’s crimes shocked the community with their brutality and the apparent disregard for his surroundings.

John Allen Muhammad and Lee Boyd Malvo killed 10 people and injured 3 others in the Washington D.C. metropolitan area during a three-week period in October 2002. This episode details the chronology of shootings, the investigation process, the modified Chevrolet Caprice used as a mobile sniper's nest, the tarot card message ("Dear Policeman, I am God"), and other communications with police.

Heather Elvis, a 20-year-old woman from Myrtle Beach, vanished in 2013. Her disappearance led to a media frenzy and widespread speculation when evidence later suggested a tangled web of infidelity, possible organized crime involvement, and questionable law enforcement leads.

A controversial theory posits that a serial killer—or possibly a network of killers—was responsible for the mysterious drowning deaths of several college-aged men in the Midwest. Proponents point to unusual similarities in the circumstances of these deaths and the appearance of smiley face graffiti near some crime scenes.

Dozens of bodies—primarily of young women—have been discovered along the Ocean Parkway near Gilgo Beach.

Twelve-year-old Polly Klaas was abducted at knifepoint from her Petaluma, California, bedroom during a sleepover on October 1, 1993. Richard Allen Davis took Polly into the night, sparking a massive manhunt. Her remains were found two months later, and Davis was eventually convicted. The case received intense national media coverage.

On August 28, 2003, pizza delivery driver Brian Wells robbed a bank in Erie, Pennsylvania, with a bomb locked to his neck. He claimed he was forced to commit the heist under duress. The bomb detonated during a police standoff, killing him. Investigators uncovered a web of conspirators allegedly led by Marjorie Diehl-Armstrong. The group orchestrated an elaborate scavenger-hunt-like plot, sending Wells on a route to collect clues that would supposedly unlock the device.

Susan Powell disappeared from her West Valley City home on December 6, 2009. Her husband, Josh Powell, claimed he took their young sons on a midnight camping trip in freezing weather—an alibi that raised suspicion. When Josh later lost custody of the children, he killed himself and both boys in a murder-suicide house explosion. Susan’s body has never been found.