Transforming Skin Cells into Neurons to Treat Alzheimer’s with Brendon Boot of Skin2Neuron
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Transforming Skin Cells into Neurons to Treat Alzheimer’s with Brendon Boot of Skin2Neuron
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About this listen
Greg and Matias interview Brendon Boot of Skin2Neuron. Brendon is a neurologist at Harvard and Mayo Clinic with prior experience as Medical Director at Biogen overseeing their Phase 1b Alzheimer’s trials.
In this episode, we discuss:
- How skin-derived cells can be turned into neurons to repair the brain.
- Why replacing lost neurons may succeed where drugs have failed in Alzheimer’s.
- What makes autologous (self-derived) cell therapy safer and more effective.
- How testing in dogs brought stronger proof than traditional mouse models.
- Why this approach could shift Alzheimer’s treatment from slowing decline to restoring memory.
Credits:
Created by Greg Kubin and Matias Serebrinsky
Host: Matias Serebrinsky & Greg Kubin
Produced by Caitlin Ner & Nico V. Rey
Find us at businesstrip.fm and psymed.ventures
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Theme music by Dorian Love
Additional Music: Distant Daze by Zack Frank
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