This Week in Virology

By: Vincent Racaniello
  • Summary

  • TWiV is a podcast about viruses - the kind that make you sick.
    Vincent Racaniello 2022
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Episodes
  • TWiV 1217: Alternative vax and pandemic origins
    May 11 2025

    TWiV reviews new CBER chief at FDA, ending of Gates Foundation in 2045, gain of function executive order, origins of bat viruses ancestral to SARS-CoV and SARS-CoV-2, and single dose Sudan virus replicon vaccine protects guinea pigs from disease.

    Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

    Subscribe (free): Apple Podcasts, RSS, email

    Become a patron of TWiV!

    Links for this episode
    • Support science education at MicrobeTV
    • Prasad replaces Marks at FDA (US News)
    • Gates Foundation ends 2025 (Gates Foundation)
    • Gain of function Executive Order (White House)
    • DURC policy (HHS)
    • Origins of bat viruses ancestral to SARS-CoV and SARS-CoV-2 (Cell)
    • Sudan virus replicon vaccine (Nat Comm)
    • Letters read on TWiV 1217
    • Timestamps by Jolene Ramsey. Thanks!
    Weekly Picks

    Rich – Andor Season 2
    Alan – Sequencing Mendel’s pea plant traits, and a good Science news article on the work
    Vincent – 2023 summer warmth unparalleled over the past 2,000 years

    Listener Pick

    Brian – Virology Capabilities Test (VCT): A Multimodal Virology Q&A Benchmark

    Intro music is by Ronald Jenkees

    Send your virology questions and comments to twiv@microbe.tv

    Content in this podcast should not be construed as medical advice.

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    1 hr and 53 mins
  • TWiV 1216: Clinical update with Dr. Daniel Griffin
    May 10 2025
    In his weekly clinical update, Dr. Griffin with Vincent Racaniello bemoan the attack on science within the US, salt water controls for vaccines, return to 1938 technology for flu vaccines, mRNA vaccines as “bioweapons”, rise in pertussis, benefits of the shingles vaccine and reduced dementia occurrence, and growing measles outbreak globally before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, the May 22 VRBPAC COVID-19 vaccine, meeting, where to find PEMGARDA, return to antibiotic treatment for respiratory viral diseases, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Saline placebo control testing for new vaccines….not good chemistry! (Washington Post)1940s innovation: HHS, NIH Launch Next-Generation Universal Vaccine Platform for Pandemic-Prone Viruses(US Department of Health and Human Services)WHAT! Minnesota Bill Against Vaccines Promotes Disinformation (Medscape Medical News) )Guns= fine….mRNA =mRNA Bioweapons Prohibition Act; mRNA injections and products designated as weapons of mass destruction, and mRNA injections and products prohibited. (Minnesota Legislature) Bioweapons of massive destruction mNRA not bombs or drones….but mRNA! (Minnesota Legislature)2024 Provisional pertussis surveillance report (CDC)Pertussis cases by year 1922-2023 (CDC: Whooping cough (pertussis)) Deaths by pertussis: 6 children under a year old (CDC)Pertussis (WHO)Symptoms of pertussis (CDC Whooping Cough (Pertussis)With whooping cough cases on the rise, a doctor explains how to protect yourself and others (CNN) Live zoster vaccination and cardiovascular outcomes (European Heath Journal)Shingles vaccine recipients see lower cardiac event risk (CIDRAP)H5 Bird Flu: Current Situation (CDC: Avian Influenza Bird flu)Measles cases and outbreaks (CDC Rubeola)Measles 800 in Texas…. (Texas Health and Human Services)2025 Measles outbreak guidance (New Mexico Health)Measles and rubella weekly monitoring report: (Government of Canada)Measles vaccine recommendations from NYP (jpg) Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola))Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Measles (CDC Measles (Rubeola))Measles (CDC: Measles Rubeola)Adverse events associated with childhood vaccines: evidence bearing on causality (NLM)Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America)Deaths following vaccination: what does the evidence show (Vaccine)Influenza: Waste water scan for 11 pathogens (WastewaterSCan)US respiratory virus activity (CDC Respiratory Illnesses)Weekly surveillance report: clift notes (CDC FluView)Respiratory virus activity levels (CDC Respiratory Illnesses)CDC reports 216 child deaths this flu season (AP News)Weekly surveillance report: clift notes (CDC FluView) FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA)RSV: Waste water scan for 11 pathogens (WastewaterSCan)US respiratory virus activity (CDC Respiratory Illnesses)RSV-Network (CDC Respiratory Syncytial virus Infection)Impact of Nirsevimab on RSV and Non-RSV Severe Respiratory Infections in Hospitalized Infants (Influenza and other respiratory viruses)Hospital admissions of respiratory infections in infants plunge with nirsevimab RSV antibody(CIDRAP)Waste water scan for 11 pathogens (WastewaterSCan)COVID-19 deaths (CDC)COVID-19 national and regional trends (CDC)COVID-19 variant tracker (CDC)SARS-CoV-2 genomes galore (Nextstrain)Early effectiveness of the BNT162b2 KP.2 vaccine against COVID-19 in the US Veterans Affairs Healthcare System (Nature Commications)Interim Clinical Considerations for Use of COVID-19 Vaccines in the United States (CDC: COVID-19)COVID-19 vaccine VRBPAC May 22 (FDA)Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC)NIH COVID-19 treatment guidelines (NIH)Drug interaction checker (University of Liverpool) Infectious Disease Society guidelines for treatment and management (ID Society)Time to antiviral treatment in mild–moderate COVID-19 in the emergency department(Internal and Emergency Medicine) Delays in COVID antiviral receipt raised risk of poor outcomes after ED visits by 18%, data suggest(CIDRAP)Molnupiravir safety and efficacy (JMV)Convalescent plasma recommendation for immunocompromised (ID Society)What to do when sick with a respiratory virus (CDC)When your healthcare ...
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    50 mins
  • TWiV Special: A shot of HepB with Thomas Tu
    May 6 2025

    From the 2024 International Hepatitis B virus meeting in Chicago IL, Rich Condit speaks with Thomas Tu about his experiences as a both a HepB scientist and patient.

    Host: Rich Condit

    Guest: Thomas Tu

    Subscribe (free): Apple Podcasts, RSS, email

    Become a patron of TWiV!

    Links for this episode
    • Support science education at MicrobeTV
    • Hepatitis B Foundation
    • Tu Laboratory
    • Timestamps by Jolene Ramsey. Thanks!

    Intro music is by Ronald Jenkees

    Send your virology questions and comments to twiv@microbe.tv

    Content in this podcast should not be construed as medical advice.

    Show More Show Less
    25 mins

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