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This Week in Startups

This Week in Startups

By: Jason Calacanis
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Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.Jason Calacanis
Episodes
  • We built OpenClaw Ultron to replace 20 people at our company | E2246
    Feb 7 2026

    This Week In Startups is made possible by:


    Crusoe Cloud - https://crusoe.ai/savings


    Lemon IO - https://Lemon.io/twist


    Northwest Registered Agent - https://www.northwestregisteredagent.com/twist


    Thanks to our guests:


    Alex Cheema of ExoLabs http://exolabs.net


    Ryan Yanneli of NextVisit https://nextvisit.ai/


    Today’s show:


    It’s the Age of Ultron at TWiST and LAUNCH. We’ve given our OpenClaw digital Replicants the keys to all of our systems and we’re seeing how much of our jobs they can really do when left to their own devices.


    Producer Oliver stops by the show to give us a peek behind the curtain, at the new control panel and dashboard OpenClaw built FOR ITSELF (with a bit of human assistance).


    PLUS we’re joined by Alex Cheema of ExoLabs. His company helps everyday consumers run powerful frontier LLMs on their own devices, essential to protect your data and personalize your AI experience.


    ALSO congratulations to Ryan Yanneli from NextVisit on winning our Gamma Pitch Deck Competition! He walks away with $25K from LAUNCH and our friends at Gamma.


    Timestamps:


    (00:00) Introducing Alex Cheema to the show


    (3:17) Why it is so important to run AI on local hardware


    (6:58) Using OpenClaw Producer to automate TWiST


    (8:59) How to Train your AI


    (11:58) What is a Chron Job? (Hint: chron means chronological)


    (13:24) Crusoe Cloud: Crusoe is the AI factory company. Reliable infrastructure and expert support. Visit https://crusoe.ai/savings to reserve your capacity for the latest GPUs today.


    (17:53) OpenClaw managing the LAUNCH/TWiST team


    (19:54) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist


    (20:58) Turning AI into Ultron, self optimization


    (27:21) The Future: frontier models: running on your Iphone!


    (28:37) Prompt injections: how people can hack your OpenClaw


    (30:25) Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://www.northwestregisteredagent.com/twist


    (31:31) OpenClaw invites guests that join the show


    (40:29) Oliver shows off OpenClaw mission control dashboard


    (46:30) Stacking Apple Silicon vs. Running Kimi-K


    (50:18) How Exo Labs works — stringing together Mac Silicon


    (54:29) Ryan from Nextvisit wins Gamma Pitch Competition


    (59:10) Industry Season 4 reflects tech regulation


    *


    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com


    Check out the TWIST500: https://www.twist500.com


    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp


    *


    Follow Lon:


    X: https://x.com/lons


    *


    Follow Alex:


    X: https://x.com/alex


    LinkedIn: https://www.linkedin.com/in/alexwilhelm/


    *


    Follow Jason:


    X: https://twitter.com/Jason


    LinkedIn: https://www.linkedin.com/in/jasoncalacanis/


    *


    Thank you to our partners:


    (13:24) Crusoe Cloud: Crusoe is the AI factory company. Reliable infrastructure and expert support. Visit https://crusoe.ai/savings to reserve your capacity for the latest GPUs today.


    (19:54) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist


    (30:25) Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity — Learn more at https://www.northwestregisteredagent.com/twist


    Check out all our partner offers: https://partners.launch.co/

    Show More Show Less
    1 hr and 11 mins
  • Savvy is HQ Trivia + Wordle (feat. Scott Rogowsky) | E2245
    Feb 4 2026

    This Week In Startups is made possible by:


    Circle - http://Circle.so/twist


    Caldera Lab - http://calderalab.com/TWIST


    LinkedIn - http://linkedin.com/twist


    Today’s show:


    There was a time, not long ago, when offices everywhere came to a standstill, and everyone became even more fixated on their phones than usual, each time HQ Trivia went live. The app-based game show was a massive viral hit… until suddenly, around a year later, it wasn’t.


    Now, HQ Trivia host Scott Rogowsky is back with a new concept: Savvy, another game show you play on your phone, this time inspired by the word puzzle hit Wordle. Is lightning about to strike twice?


    PLUS, Alex chats with Trevor Bennett of space transportation outfit Starfish Space. This comes off two major successes for the team: the Remora mission that proved Stafish’s autonomous rendezvous capabilities and the $52.5 Million dollar contract to dispose of low Earth orbit satellites.


    Timestamps:


    (00:00) How Scott first got involved with HQ Trivia


    (2:23) Why Scott thinks HQ Trivia struck such a chord with fans


    (4:12) Scott couldn’t get a job in late night, so he made his own show


    (5:31) Delving into the behind-the-scenes tensions at HQ Trivia


    (11:07) Circle - the easiest way to build a home for your community, events, and courses — all under your own brand. TWiST listeners get $1,000 off the Circle Plus Plan by going to http://Circle.so/twist


    (13:53) The end of HQ Trivia and why Scott jumped ship


    (16:35) Savvy just had its series premiere: you play the game against the host


    (20:14) How to play Savvy and win cash


    (20:57) Why Jason thinks a subscription model is the future of Savvy


    (22:25) Whether you’re starting fresh or upgrading your routine, Caldera Lab makes skincare simple and effective. Head to http://calderalab.com/TWIST and use TWIST at checkout for 20% off your first order.


    (23:31) Introducing Dr. Trevor Bennet of Starfish Space


    (24:04) What the Otter Spacecraft does: de-orbiting to clean up space


    (26:46) Why space will need hundreds of Otters in space


    (29:24) LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at http://linkedin.com/twist Terms and conditions apply.


    (30:23) Starfish Space’s business model: operating a starfleet


    (33:17) The success of the Remora mission: autonomous rendezvous in space.


    (43:47) The rise of the space economy


    (48:18) Starfish’s $52.5 Million dollar contract and what it means for the space ecosystem


    *


    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com/


    Check out the TWIST500: https://twist500.com


    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp


    *


    Follow Lon:


    X: https://x.com/lons


    *


    Follow Alex:


    X: https://x.com/alex


    LinkedIn: https://www.linkedin.com/in/alexwilhelm/


    *


    Follow Jason:


    X: https://twitter.com/Jason


    LinkedIn: https://www.linkedin.com/in/jasoncalacanis/


    *


    Thank you to our partners:


    (11:07) Circle - the easiest way to build a home for your community, events, and courses — all under your own brand. TWiST listeners get $1,000 off the Circle Plus Plan by going to http://Circle.so/twist


    (22:25) Whether you’re starting fresh or upgrading your routine, Caldera Lab makes skincare simple and effective. Head to http://calderalab.com/TWIST) and use TWIST at checkout for 20% off your first order.


    (29:24) LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at http://linkedin.com/twist Terms and conditions apply.


    Check out all our partner offers: https://partners.launch.com

    Show More Show Less
    54 mins
  • Where early-stage founders MUST focus to success | E2244
    Feb 3 2026

    This Week In Startups is made possible by:


    Quadratic - http://quadratic.ai/twist


    Today’s show:


    Don’t get distracted! Here are the MOST CRUCIAL aspects of running a startup, where founders need to keep their full and uninterrupted focus.


    - Make sure you’re saving up your cash

    - Why you need to just get started and build SOMETHING

    - Trust and reliability is EVERYTHING for new products

    - Why distribution should be your top priority


    Download all this practical and tactical startup advice from seasoned veterans Jason Calacanis, Amanda Bradford, and William P. Barnes in this Tokyo edition of TWiST.


    Timestamps:


    (00:00) Amanda and Will’s big takeaways from Founder U in Saudi Arabia and now Tokyo


    (3:19) Why cash flow management is so important before you find PMF


    (5:57) Why first-time founders get the order of operations wrong


    (6:45) Just build SOMETHING, even if it’s taped together


    (11:19) “Focus is everything in the early stages”


    (14:17) From a wedge to a bridge


    (15:50) Quadratic - Bringing the productivity boost of AI into your spreadsheets. Visit http://quadratic.ai/twist to sign up and use the code TWIST to get one free month of their pro tier subscription.


    (18:45) What to put on your “Not Right Now” list


    (19:11) Embracing simplicity


    (22:00) The importance of trust and reliability (especially for Uber!)


    (28:12) Why innovation needs a constraining variable


    (33:40) To really drive word of mouth, you have to overdeliver


    (36:32) Distribution is the primary job of a founder/CEO


    (38:19) Some of the panel’s favorite distribution hacks


    (45:54) Why Jason respects Japan’s commitment to excellence and competency


    (49:38) Looking for “high slope” in early employees


    (53:11) Transitioning your team from early-stage startup to growth


    (57:45) Whoever writes it down gets credit for the idea


    (58:04) Q: Has the meaning of money changed for the panel now that they’ve had successful exits?


    *


    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com/


    Check out the TWIST500: https://twist500.com


    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp


    *


    Follow Lon:


    X: https://x.com/lons


    *


    Follow Alex:


    X: https://x.com/alex


    LinkedIn: https://www.linkedin.com/in/alexwilhelm/


    *


    Follow Jason:


    X: https://twitter.com/Jason


    LinkedIn: https://www.linkedin.com/in/jasoncalacanis/


    *


    Thank you to our partners:


    (15:50) Quadratic - Bringing the productivity boost of AI into your spreadsheets. Visit http://quadratic.ai/twist to sign up and use the code TWIST to get one free month of their pro tier subscription.


    Check out all our partner offers: https://partners.launch.co/

    Show More Show Less
    1 hr and 7 mins
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