TWiP reviews a phase 2 clinical trial of a recombinant vaccine against N. americanus glutathione S-transferase-1, an enzyme that performs a crucial enzymatic step in
hookworm blood feeding.

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• Phase 2 hookworm vaccine clinical trial (Lancet Inf Dis)
• Phase 2 Schistosoma vaccine clinical trial (Vaccines)
• TWiP study – information and survey

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Music by Ronald Jenkees

TWiP solves the case of the male in his 20s from Hokkaido, Japan, who developed fatigue and rash, followed by fever and myalgia 6 days later, after eating a raw bear eyeball.

Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula

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• Hero: Sir Nicholas White (1951 – 2026) (Guardian, Lancet)
• Letters read on TWiP 278
• TWiP study – information and survey

New Case

3 yo child who recently immigrated to the US from Central America is brought in to the ER with acute right lower quadrant abdominal pain. The mother is concerned about the pain as well as nausea and vomiting. This is acute and the ER provider is concerned that this might be an acute surgical emergency. They order an US in this child and they are surprised to see a rather active serpiginous wormlike 'thing' wiggling away in the child's appendix. I was sent the Ultrasound video which I really enjoyed. What to do?

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Music by Ronald Jenkees

TWiP reviews the global, regional, and national burden of Chagas disease, and comparison of doxycycline and rifampicin for the treatment of onchocerciasis.

Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula

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• Burden of Chagas' disease (Lancet Inf Dis)
• Doxycycline vs rifampicin in treatment of river blindness (Open For Inf Dis)
• The kissing bug by Daisy Hernandez
• TWiP study – information and survey

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Music by Ronald Jenkees