It comes on sneakily. You become aware of your stomach. You break out in a cold sweat. Your mouth fills with saliva. And before you know it, you’re leaning over the side of the boat (or out of the car, or into the airplane sick bag), barfing up your breakfast. Motion sickness. We’ve all been there, or at least most of us have. Why? What is it about our physiology that breaks down as soon as we travel via water, vehicle, or air? That’s exactly what we’re going to explore in this episode. From how long humans (and other species) have been coping with these debilitating symptoms to what’s actually going on in your brain to trigger the breakdown, from what’s in the most nauseating historical “cures” for motion sickness to why the drugs we have today have some positive effect, we’re covering it all.

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Once thought to be a rare, always fatal disease, histoplasmosis is now recognized as one of the most prevalent fungal infections in North America. It infects hundreds of thousands of people every year, and its distribution is growing. In this episode, we dissect this abundant fungus, examining how it makes us sick, who tends to get sick, and what we can do about it. We also take you through the history of this fungus, a story that features a surprise discovery, more evidence that everything is tuberculosis, and a spotlight on an extinct bird. Curious to know how all the pieces fit together? Tune in for the full picture.

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In a time when smallpox, tuberculosis, measles, and typhus ran rampant through the streets of London, there was another disease that instilled even more fear than these other killers: syphilis. So feared and so stigmatized was syphilis that it was sometimes called “the secret disease.” A diagnosis would not only sentence you to a drawn-out and painful illness possibly resulting in death, it also labeled you as an outcast and not fit for polite company. Skyrocketing infection rates drove a corresponding rise in syphilis “cures” and an increasingly desperate public. In this TPWKY book club episode, Dr. Olivia Weisser, associate professor of history at the University of Massachusetts, Boston joins me to discuss her recent book The Dreaded Pox: Sex and Disease in Early Modern London. She transports readers to the hidden shops and stalls that promised a remedy to this feared disease, to the courthouses where a syphilis infection was an important piece of evidence, and to the country houses that held recipe books for those who could not purchase a cure. Tune in for a fascinating glimpse into a time and place where morality, sex, and disease were so strongly entangled.

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