Microdosing has gone mainstream and is often described as a tool for creativity, mood, productivity, and emotional healing. But what does the science actually say?

In this episode of The Trip Lab, I take an evidence-based look at microdosing psychedelics. We explore what microdosing is, how it differs from full-dose psychedelic therapy, and the proposed neurobiological mechanisms that have been suggested in the literature. I review what current clinical trials and placebo-controlled studies are showing so far, and where the data remains limited or inconclusive.

A central focus of this episode is the placebo response. Rather than treating placebo as “fake” or irrelevant, I explain how expectancy, meaning, belief, and context produce real, measurable changes in the brain and body. We discuss why placebo responses are especially strong in interventions involving consciousness, perception, and mental health, and how this helps explain why many people genuinely feel better with microdosing even when objective outcomes are mixed.

This episode separates enthusiasm from evidence, explores where microdosing may be helpful, where claims get overstretched, and what questions researchers are actively trying to answer next.

If you’re curious about microdosing and want a grounded, medically informed perspective that respects both science and lived experience, this conversation is for you.

Functional medicine testing is everywhere. It is often marketed as “test, don’t guess,” and just as often dismissed as invalidated or unscientific. So what is the truth?

In this episode of The Trip Lab, we take a deep dive into what functional medicine testing actually is, how it differs from traditional laboratory testing, and what clinicians really mean when they say these tests are not “validated.” We explore why some advanced tests can be genuinely helpful when used thoughtfully, where their limitations lie, and why more testing does not always lead to better care.

We walk through several commonly used functional medicine tests that I actually do use in my practice, including DUTCH, GI-MAP, and Organic Acids Testing (OAT), breaking down what each test measures, when it can add value, and … when it might not be helpful as well. We also discuss why I typically don’t recommend mold or environmental toxin testing, and why exposure history and foundational interventions often matter more than identifying a specific toxin.

Is modern medicine still evidence-based, or have we quietly mistaken rigor for certainty?

Evidence-based medicine is essential. It’s why we save lives, advance care, and trust modern healthcare. But as medicine has become more specialized and disease more complex, something subtle has happened. Rigor has increasingly turned into reductionism, and evidence is often applied in ways that don’t fully match the realities of clinical practice or patients’ lived experiences.

In this episode of The Trip Lab, I take a careful look at what we mean when we say “evidence-based medicine.” We explore the difference between statistical significance and clinical significance, how guidelines are created and why they are evidence-informed rather than infallible, and why many patients feel unwell despite having “normal” labs.

This conversation also examines how modern research methods struggle to capture complexity, particularly in chronic, system-level disease. We look at where reductionism has helped medicine advance, where it now falls short, and why ancient healing systems and emerging fields like systems biology, functional medicine, and precision medicine are pointing us toward a more integrated future.

This episode is not a rejection of evidence. It’s an invitation to reclaim it. To restore clinical wisdom alongside data, and to practice medicine with both rigor and curiosity.

In this episode, we cover:

• What “evidence-based medicine” actually means and how it’s evolved
• Statistical significance vs. clinical significance
• The strengths and limitations of medical guidelines
• Why reductionist models don’t fully explain chronic disease
• Why patients can feel unwell even when labs are “normal”
• How medicine might evolve to better study complexity
• Why medicine is both a science and an art

The podcast name, The Trip Lab, nods to psychedelics, but a “trip,” psychedelic or otherwise, is ultimately an exploration. A willingness to step outside familiar frameworks, question what we think we know, and notice connections that weren’t obvious before.

If you’ve ever felt tension between what the data says, what the guidelines allow, and what the patient in front of you actually needs... or if you are a patient who has been failed by modern medicine, this episode is for you.