The SLC-ome of Membrane Transport
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The SLC-ome of Membrane Transport
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About this listen
In our latest episode, Associate Editor Dr. John Orlowski (McGill University) interviews Dr. Matthias A Hediger (University of Bern) about the new Review article by Gyimesi et al. published in Physiological Reviews on the intracies of a superfamily of membrane solute carriers that is critically important to our understanding of human health and disease. This extensive Review contains over 3500 citations describing the superfamily of solute carriers the authors refer to as “The SLC-ome.” These SLCs comprise the largest group of membrane transport proteins encoded by the human genome and are responsible for moving numerous solutes and other essential biological compounds in and out of cells. Ready to learn more about how the SLC-ome is essential to mediating the movement of nutrients, electrolytes, metabolites and other molecules, such as pharmacological drugs, across cellular and organellar membranes? Listen now to learn more.
Gergely Gyimesi, Susan Tweedie, Elspeth Bruford, and Matthias A Hediger The SLC-ome of membrane transport: From molecular discovery to physiology and clinical applications Physiological Reviews, published September 30, 2025. DOI: 10.1152/physrev.00001.2024