What if the way we approach mental health is quietly making things worse?

Psychiatrist and psychotherapist Sami Timimi joins Michael Shermer to examine some of the core assumptions behind modern psychiatry. Why have diagnoses such as ADHD, autism, anxiety, and depression expanded so dramatically—and why hasn’t increased access to treatment led to better outcomes at the population level?

Timimi describes how diagnostic categories have broadened over time and questions whether psychiatric labels function in the same way as medical diagnoses elsewhere in healthcare. Without clear biological markers, he argues, definitions can expand to include forms of distress that were once considered part of ordinary human experience.

The conversation also considers the role of meaning, identity, and culture in shaping how people understand psychological suffering. Timimi reflects on the limits of medication and therapy, the unintended consequences of the “mental illness as physical illness” model, and how social media may contribute to the spread and reinforcement of certain diagnostic categories.

Dr. Sami Timimi is a child and adolescent psychiatrist, psychotherapist, and Fellow of the Royal College of Psychiatrists. He has published more than 150 academic papers and authored or edited over a dozen books, including Naughty Boys, Liberatory Psychiatry, and The Myth of Autism. His new book is Searching for Normal: A New Approach to Understanding Mental Health, Distress, and Neurodiversity.

What is consciousness, really? Why does it not simply switch on at a single moment? Neuroscientist Niko Kukushkin explains how even single cells can show primitive forms of memory and agency, why the human mind is not a mysterious force floating above biology, and why reducing it to “just neurons” misses what actually matters.

He also discusses the evolutionary gamble of complexity, why bacteria still dominate the planet, and how abstraction and memory together give rise to thought.

At the center of the conversation is an unsettling question: Why does it feel so special to be you when science says that you are nothing but a chemical reaction—a collection of atoms and molecules, like rocks, paperclips, and everything else in the physical universe?

Nikolay Kukushkin is a clinical associate professor at New York University and a research fellow at NYU’s Center for Neural Science, where he studies how temporal patterns shape memory formation. He holds degrees from St. Petersburg State University and Oxford University, and completed postdoctoral training at Harvard Medical School. He is the author of a recent paper in Nature Communications demonstrating canonical memory in non-neural cells. His book is One Hand Clapping.

Francis Crick is best known as one of the figures behind the discovery of the double-helix structure of DNA, but the familiar story leaves out as much as it explains. Historian of science Matthew Cobb looks closely at how Crick’s life actually unfolded, revealing a career shaped less by inevitability than by luck, conflict, false starts, and a series of highly contingent moments.

The double helix itself may have been waiting to be found, but what followed was anything but predetermined. Crick’s influence came from asking uncomfortable questions about what the structure of DNA implied for genetics, evolution, and life itself. Along the way, myths hardened around personalities, credit, and rivalries, especially in the case of Rosalind Franklin, whose role has been both misunderstood and oversimplified.

The conversation also traces Crick’s later turn away from molecular biology toward the problem that fascinated him from the beginning: consciousness. From visual perception to the search for neural correlates of experience, his ambition was to push back against mystical explanations and insist that even the most elusive aspects of the mind belonged to the material world.

Matthew Cobb is a professor in the School of Biological Sciences at the University of Manchester. He is the author of numerous works of science and history. His new book is Crick: A Mind in Motion, a biography of the legendary scientist Francis Crick, co-discoverer of the structure of DNA.