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The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

By: Dave Asprey
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For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

© Copyright © Bulletproof Media 2023 Hygiene & Healthy Living Personal Development Personal Success Science
Episodes
  • Biohacking Fertility for Men and Women at Any Age : 1381

    Biohacking Fertility for Men and Women at Any Age : 1381
    Dec 16 2025
    This episode lays out the blueprint for having healthier children later in life by treating preconception as the most important window for human health. You’ll learn why fertility is not just about getting pregnant, but about building the biological foundation that shapes a child’s brain development, metabolism, immune function, and long term resilience. This conversation reframes infertility as a meaningful signal to pause, repair, and prepare, instead of something to override or rush past. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Dr. Ann Shippy is a board-certified internal medicine physician, certified functional medicine practitioner, and a leading expert in preconception health and fertility optimization. A former IBM chemical engineer, she brings a rare systems-based and data-driven approach to uncovering the root causes of infertility, chronic disease, and hormonal dysfunction. Through her Austin-based medical practice, she has helped men and women restore fertility naturally and conceive healthy children well into their 40s using advanced lab testing, precision supplements, and targeted functional medicine strategies. Together, Dave Asprey and Dr. Shippy explore why childhood illness and infertility are rising at the same time, and how environmental toxins, mold exposure, microbiome imbalances, sleep disruption, and chronic inflammation undermine fertility in both men and women. They discuss the role of mitochondria, circadian rhythms, thyroid health, testosterone, and epigenetics in reproductive health, and why IVF should not be the first step without addressing underlying biological dysfunction. You’ll Learn: • Why preconception matters more than pregnancy for long term child health • How sperm and egg quality act as biological time capsules for future generations • Why infertility functions as a warning signal instead of a random failure • How environmental toxins and mold exposure disrupt fertility and mitochondrial health • The connection between fertility, longevity, and overall human performance • Why sleep, circadian rhythm, and stress strongly influence reproductive hormones • The role of thyroid function and testosterone in fertility and metabolism • When IVF makes sense and why it should not bypass foundational health work Thank you to our sponsors! Dave's Biohacking Holiday Gift Guide | Go to https://daveasprey.com/giftguide/ to explore the full guide.GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what’s in your air.Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: preconception health, fertility optimization, healthy pregnancy preparation, sperm and egg quality, epigenetic inheritance, generational health, infertility root causes, environmental toxins fertility, mitochondrial health fertility, functional medicine fertility, hormone balance fertility, IVF alternatives, natural fertility strategies, longevity and reproduction, human performance biology, sleep and fertility, circadian rhythm health, supplements for fertility, smarter not harder health, Dave Asprey fertility, Human Upgrade fertility, Dr. Ann Shippy, Ann Shippy MD, Ann Shippy fertility expert, Ann Shippy preconception, The Preconception Revolution Resources: • Dr Shippy’s New Book ‘The Preconception Revolution’: https://annshippymd.com/the-preconception-revolution/ • Dr Shippy’s Website: https://annshippymd.com/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 ...
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    1 hr and 4 mins
  • Your Brain Has A Sleep Switch (Do THIS To Turn It On) : 1380

    Your Brain Has A Sleep Switch (Do THIS To Turn It On) : 1380
    Dec 14 2025
    Try TrueDark Glasses: https://truedark.com/?coupon-code=DAVETUBE&sc-page=shopKill your zombie cells with: http://www.qualialife.com/davenadYour brain has a built-in switch that controls deep sleep but for most people, it’s turned off.In this video, Dave Asprey exposes the hidden factors blocking your deep sleep. He shows how small changes to posture, meal timing, and lighting can reactivate your brain’s sleep control center so you sleep deeper, recover faster, and wake up refreshed, all in 6.5 hours a night.*** Dave's Biohacking Holiday Gift Guide | Go to https://daveasprey.com/giftguide/ to explore the full guide. ***Thank you to our sponsors! • ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask.• AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers.Timestamps00:00 – The Hidden Sleep Switch Nobody Talks About01:35 – The Root Causes of Bad Sleep02:13 – The Invisible Force Ruining Your Sleep03:48 – The Worst Sleeping Positions (and Why)04:30 – Correct Setup for Side and Back Sleepers06:23 – Why Food Timing Destroys Deep Sleep08:29 – The 3-Hour Rule09:33 – The Circadian Rhythm Problem in Modern Life11:30 – The Brain’s Master Clock12:30 – Mimicking Nature with Morning and Evening Light14:20 – Proof That Light Manipulation Works15:05 – How to Reset Your Circadian Rhythm Step-by-StepResources: • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: Instagram: https://www.instagram.com/TheHumanUpgradePodcast/ Facebook: https://m.facebook.com/Thehumanupgrade/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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    16 mins
  • The One Thing Everyone Thinks They Can’t Afford… Until They Try It : 1379

    The One Thing Everyone Thinks They Can’t Afford… Until They Try It : 1379
    Dec 12 2025
    If you want more time, better energy, and a calmer mind, this episode gives you a blueprint for achieving it. Host Dave Asprey talks with entrepreneur Jonathan Swanson, who explains how delegation functions as a powerful form of biohacking that frees cognitive load, improves sleep quality, protects your mitochondria from chronic stress, and opens space for longevity, brain optimization, supplements, fasting, ketosis, and the full Human Upgrade approach. Jonathan shows how eliminating low value tasks can reclaim hours every day and upgrade your human performance far more than people realize. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Jonathan Swanson is the Founder and Chairman of Thumbtack and Athena, two global companies he scaled to more than one thousand team members each. He has raised over seven hundred million dollars from leading investors including Sequoia Capital, Google Capital, and Blackstone. At Thumbtack he built one of the top marketplaces for local services. At Athena he created an elite academy for executive assistants and leadership development. Jonathan also served in the West Wing for the President’s chief economic advisor, giving him rare insight into time leverage, decision making, and performance under pressure. Jonathan breaks down why overloaded to do lists elevate stress hormones, reduce neuroplasticity, interfere with recovery, and sabotage longevity goals. He explains how removing decision fatigue improves metabolism and cognitive function, how AI can accelerate human support instead of replacing it, and why even small forms of leverage increase ambition, resilience, and overall life satisfaction. Jonathan shares real examples from scaling billion dollar companies, building global teams, managing his own health routines, and designing systems that create more time for family, recovery, and meaningful work. You’ll Learn: • Why leverage comes before ambition, not after, and how that shift changes what you believe is possible in your life • How Jonathan went from 16 to 18 hour days and polyphasic sleep to becoming a “time billionaire” through ruthless delegation • The cardinal sin of delegation, why doing it yourself feels faster at first, and how that belief traps you in busywork • The stages of delegation, from single tasks to projects to goals to “clairvoyant delegation,” where you first hear about a task when it is already done • How to start at any budget level, from using AI as a starter assistant, to hiring directly on global platforms, to working with a fully trained Athena EA • Practical ways an assistant can support biohacking, sleep optimization, supplements, lab tracking, family logistics, and even creative life projects • How to build trust, set boundaries, and protect security when you work with remote assistants who have access to sensitive parts of your life• Why human plus AI assistants beat AI alone, and how the next generation of support will supercharge human performance instead of replacing it • How to think about your hourly rate so you stop doing tasks that kill your metabolism, focus, and long term longevity Thank you to our sponsors! -BEYOND Conference 2026 | Register now at https://beyondconference.com/ -BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. -Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. -Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body’s really doing behind the surface. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: time leverage, personal delegation, executive assistant training, Athena assistant, cognitive load reduction, decision fatigue relief, daily workflow optimization, biohacking time freedom, human plus AI support, inbox offloading, calendar management, task automation, overwhelm reduction, founder performance, global talent recruitment, delegation ladder, clairvoyant delegation, lifestyle efficiency, home logistics support, entrepreneurial time scaling Resources: • Athena Website: Go to https://athena.com/upgrade for a generous discount! • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today....
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    52 mins
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