In today’s episode, William Mulligan sits down with neuroscientist and psychedelic researcher Manesh Girn to explore the intersection of Stoic philosophy and modern science. Manesh shares his perspective on core Stoic ideas such as virtue, the dichotomy of control, and amor fati, while drawing connections to the transformative potential of psychedelics.

The conversation dives into themes of neuroplasticity, the role of health in living virtuously, and how both Stoicism and psychedelics can help us overcome trauma, reframe our perceptions, and live more fully in the present.

From discussing Marcus Aurelius and Epictetus to the neuroscience of predictive coding and emotional breakthroughs, this episode offers a rich look at how ancient wisdom and contemporary research can complement each other in the pursuit of a good life.

In this episode, William reflects on the nature of struggle and why hardship is not something to be avoided, but embraced as a sign of growth. He explains that pain and inner conflict are evidence of courage, proof that one is still in the fight rather than surrendering to nihilism, cynicism, or escapism. Drawing from Stoic philosophy, Buddhist teachings, and the myth of Hercules, he shows how challenges act as life’s sparring partners, shaping character and revealing harmful patterns that must be overcome.

William emphasizes the importance of self-compassion, urging listeners to treat themselves with the same kindness they would offer a loved one in distress. He reminds us that though the path ahead may be unclear and unfamiliar, it is precisely this uncertainty that makes it ours to walk. Each small step, however insignificant it may seem, is a victory that strengthens resilience and reveals the way forward.

In this episode of The Everyday Stoic, William Mulligan is joined by Oxford-educated neuroscientist Dr. Sarah McKay to explore Stoic philosophy through a scientific lens.

Dr. McKay provides her expert opinion on the core principles of Stoicism, examining the four cardinal virtues of wisdom, courage, justice, and temperance from a developmental and neurological perspective. The conversation covers practical Stoic exercises, such as the Dichotomy of Control and the concept of Premeditatio Malorum

In the conversation, they explore the understanding of how these philosophical concepts align with our understanding of the human brain, how virtues may change and develop across our lifespan, and how to apply these ideas to cultivate resilience and live a more examined life.