Drs Harrington, Rodriguez, and Ridker discuss the changing field of cardiac prevention, where imaging fits in, and the new concept of standard modifiable risk factor-less patients.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit

https://www.medscape.com/author/bob-harrington

Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association

https://doi.org/10.1161/CIR.0000000000001078

Development and Validation of the American Heart Association's PREVENT Equations

https://doi.org/10.1161/CIRCULATIONAHA.123.067626

C-Reactive Protein and Cardiovascular Risk Among Women With No Standard Modifiable Risk Factors: Evaluating the 'Smurf-Less but Inflamed'

https://doi.org/10.1093/eurheartj/ehaf658

Mortality in STEMI Patients Without Standard Modifiable Risk Factors: A Sex-Disaggregated Analysis of SWEDEHEART Registry Data

https://doi.org/10.1016/S0140-6736(21)00272-5

Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women

https://www.nejm.org/doi/10.1056/NEJMoa2405182

Statins for the 'SMuRFLess But Inflamed': Silent Vascular Inflammation and the Challenge of Translational Science

https://doi.org/10.1016/j.jacbts.2025.101318

VERVE-101: A Promising CRISPR-Based Gene Editing Therapy That Reduces LDL-C and PCSK9 Levels in HeFH Patients

https://academic.oup.com/ehjcvp/article/10/2/89/7492807

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Hear John Mandrola, MD, give a summary and his perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact news@medscape.net

Cardiologist and author Eric Topol discusses the science of longevity, why the key to healthy aging is prevention, and the perils of a fixation on reversing ageing.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington

Super Agers: An Evidence-Based Approach to Longevity

https://www.simonandschuster.com/books/Super-Agers/Eric-Topol/9781668067666

Wellderly study

https://www.scripps.edu/science-and-medicine/translational-institute/translational-research/genomic-medicine/wellderly/

Lotte Bjerre Knudsen

https://erictopol.substack.com/p/lotte-bjerre-knudsen-the-scientist

Organ aging signatures in the plasma proteome track health and disease

https://doi.org/10.1038/s41586-023-

Deep Medicine

https://drerictopol.com/portfolio/deep-medicine/

You may also like:

Hear John Mandrola, MD, give a summary and his perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact news@medscape.net

The 2021 winner of the Nobel Prize in medicine, Ardem Patapoutian speaks of his love for science, why he wishes he had an MD, and the importance of getting out of the lab to inspire young people.

This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit:

https://www.medscape.com/author/bob-harrington

Nobel Prize in Physiology or Medicine 2021

https://pubmed.ncbi.nlm.nih.gov/39429349/

https://www.nobelprize.org/prizes/medicine/2021/press-release/

Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels https://pubmed.ncbi.nlm.nih.gov/20813920/

PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex

https://doi.org/10.1126/science.aau6324

PIEZO Ion Channels in Cardiovascular Functions and Diseases

https://doi.org/10.1161/CIRCRESAHA.123.322798

You may also like:

Hear John Mandrola, MD, with his summary and perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact

news@medscape.net