Celebrity spit parties, Met Gala appearances, and dreams of personalized medicine made 23andMe the hottest thing in biotech. Anne Wojcicki’s DNA tests promised to unlock the secrets of our genes – and maybe cure some diseases along the way. But when hackers exposed millions of users' genetic data, not even Richard Branson could save Anne from becoming another Silicon Valley casualty.

Kevin Sullivan and Laura Peek join Misha to understand the building blocks of 23andMe's demise.

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Before there was Facebook, there was MySpace – and Tom Anderson was everyone's first friend. With his iconic profile pic and revolutionary platform, Tom turned social media into a cultural phenomenon. But when corporate suits came calling with fat checks and even bigger expectations, Tom went from being everyone’s first friend to the internet’s first cautionary tale.

Erika Ishii and Brennan Lee Mulligan (Dimension 20, Dropout.tv) join Misha to get the lowdown on how Tom from Myspace fell out of everyone’s top 8.

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In the early 2000s, American Apparel was the coolest kid on the block, slinging ethically-made tees and scandalous billboards. But founder Dov Charney's penchant for office orgies and nude photoshoots proved too spicy for Wall Street, turning his sweatshop-free dream into a nightmare of lawsuits, bankruptcy, and one very public walk of shame.

Sasheer Zamata and Jared Goldstein join Misha to uncover the almost naked truth behind American Apparel.

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Listen to The Big Flop on the Wondery App or wherever you get your podcasts. You can listen early and ad-free on Wondery+. Join Wondery+ in the Wondery App, Apple Podcasts or Spotify. Start your free trial by visiting wondery.com/links/the-big-flop/ now.

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.