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Talk Python To Me

Talk Python To Me

By: Michael Kennedy
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 Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive deep into the popular packages and software developers, data scientists, and incredible hobbyists doing amazing things with Python. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from the leaders. And if you've been Pythoning for years, you'll learn about your favorite packages and the hot new ones coming out of open source.Copyright 2015-2025
Episodes
  • #520: pyx - the other side of the uv coin (announcing pyx)

    #520: pyx - the other side of the uv coin (announcing pyx)
    Sep 23 2025
    A couple years ago, Charlie Marsh lit a fire under Python tooling with Ruff and then uv. Today he’s back with something on the other side of that coin: pyx.

    Pyx isn’t a PyPI replacement. Think server, not just index. It mirrors PyPI, plays fine with pip or uv, and aims to make installs fast and predictable by letting a smart client talk to a smart server. When the client and server understand each other, you get new fast paths, fewer edge cases, and the kind of reliability teams beg for. If Python packaging has felt like friction, this conversation is traction. Let’s get into it.

    Episode sponsors

    Six Feet Up
    Talk Python Courses

    Links from the show Charlie Marsh on Twitter: @charliermarsh
    Charlie Marsh on Mastodon: @charliermarsh

    Astral Homepage: astral.sh
    Pyx Project: astral.sh
    Introducing Pyx Blog Post: astral.sh
    uv Package on GitHub: github.com
    UV Star History Chart: star-history.com
    Watch this episode on YouTube: youtube.com
    Episode #520 deep-dive: talkpython.fm/520
    Episode transcripts: talkpython.fm
    Developer Rap Theme Song: Served in a Flask: talkpython.fm/flasksong

    --- Stay in touch with us ---
    Subscribe to Talk Python on YouTube: youtube.com
    Talk Python on Bluesky: @talkpython.fm at bsky.app
    Talk Python on Mastodon: talkpython
    Michael on Bluesky: @mkennedy.codes at bsky.app
    Michael on Mastodon: mkennedy
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    1 hr
  • #519: Data Science Cloud Lessons at Scale

    #519: Data Science Cloud Lessons at Scale
    Sep 18 2025
    Today on Talk Python: What really happens when your data work outgrows your laptop. Matthew Rocklin, creator of Dask and cofounder of Coiled, and Nat Tabris a staff software engineer at Coiled join me to unpack the messy truth of cloud-scale Python. During the episode we actually spin up a 1,000 core cluster from a notebook, twice! We also discuss picking between pandas and Polars, when GPUs help, and how to avoid surprise bills. Real lessons, real tradeoffs, shared by people who have built this stuff. Stick around.

    Episode sponsors

    Seer: AI Debugging, Code TALKPYTHON
    Talk Python Courses

    Links from the show Matthew Rocklin: @mrocklin
    Nat Tabris: tabris.us

    Dask: dask.org
    Coiled: coiled.io
    Watch this episode on YouTube: youtube.com
    Episode #519 deep-dive: talkpython.fm/519
    Episode transcripts: talkpython.fm
    Developer Rap Theme Song: Served in a Flask: talkpython.fm/flasksong

    --- Stay in touch with us ---
    Subscribe to Talk Python on YouTube: youtube.com
    Talk Python on Bluesky: @talkpython.fm at bsky.app
    Talk Python on Mastodon: talkpython
    Michael on Bluesky: @mkennedy.codes at bsky.app
    Michael on Mastodon: mkennedy
    Show More Show Less
    1 hr and 3 mins
  • #518: Celebrating Django's 20th Birthday With Its Creators

    #518: Celebrating Django's 20th Birthday With Its Creators
    Aug 29 2025
    Twenty years after a scrappy newsroom team hacked together a framework to ship stories fast, Django remains the Python web framework that ships real apps, responsibly. In this anniversary roundtable with its creators and long-time stewards: Simon Willison, Adrian Holovaty, Will Vincent, Jeff Triplett, and Thibaud Colas, we trace the path from the Lawrence Journal-World to 1.0, DjangoCon, and the DSF; unpack how a BSD license and a culture of docs, tests, and mentorship grew a global community; and revisit lessons from deployments like Instagram. We talk modern Django too: ASGI and async, HTMX-friendly patterns, building APIs with DRF and Django Ninja, and how Django pairs with React and serverless without losing its batteries-included soul. You’ll hear about Django Girls, Djangonauts, and the Django Fellowship that keep momentum going, plus where Django fits in today’s AI stacks. Finally, we look ahead at the next decade of speed, security, and sustainability. Episode sponsors Talk Python Courses Python in Production Links from the show Guests Simon Willison: simonwillison.net Adrian Holovaty: holovaty.com Will Vincent: wsvincent.com Jeff Triplett: jefftriplett.com Thibaud Colas: thib.me Show Links Django's 20th Birthday Reflections (Simon Willison): simonwillison.net Happy 20th Birthday, Django! (Django Weblog): djangoproject.com Django 2024 Annual Impact Report: djangoproject.com Welcome Our New Fellow: Jacob Tyler Walls: djangoproject.com Soundslice Music Learning Platform: soundslice.com Djangonaut Space Mentorship for Django Contributors: djangonaut.space Wagtail CMS for Django: wagtail.org Django REST Framework: django-rest-framework.org Django Ninja API Framework for Django: django-ninja.dev Lawrence Journal-World: ljworld.com Watch this episode on YouTube: youtube.com Episode #518 deep-dive: talkpython.fm/518 Episode transcripts: talkpython.fm Developer Rap Theme Song: Served in a Flask: talkpython.fm/flasksong --- Stay in touch with us --- Subscribe to Talk Python on YouTube: youtube.com Talk Python on Bluesky: @talkpython.fm at bsky.app Talk Python on Mastodon: talkpython Michael on Bluesky: @mkennedy.codes at bsky.app Michael on Mastodon: mkennedy
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    1 hr and 8 mins
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