Season 1 Episode 8: Lipoprotein (a)
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About this listen
LDL may get all the blame — but there’s a darker twin hiding in the shadows.
Same cholesterol core. Same ApoB backbone.
But with one sinister twist: a sticky tail called apolipoprotein(a).
That extra piece transforms an ordinary LDL particle into something far more dangerous.
Meet Lipoprotein(a) — or Lp(a) — one of the strongest, most under-recognized genetic drivers of premature cardiovascular disease.
It’s pro-atherogenic, pro-thrombotic, and pro-inflammatory — a triple threat that can quietly turn even the healthiest-looking lipid panel into a ticking time bomb.
In this episode of LipidCurious, we’ll uncover
1. What is Lp(a)?
2. How and when to test for it?
3. What to do when Lp(a) is high?
We’ll walk through genetics, testing strategy, and real-world management — plus a glimpse into the promising therapies now in late-phase trials.
By the end, you’ll understand why Lp(a) is the ghost in the lipid story — invisible on a standard panel, but capable of haunting even the fittest hearts.
Bonus: The Visual Guide for this episode is waiting for you — click here. For the full collection of visuals across episodes, visit the Podcast page.
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Disclaimer: This podcast is for educational purposes only. It is NOT medical advice.