In Part 1 of our hormone series, we explore how hormonal balance influences inflammation, metabolism, and overall musculoskeletal health. Many patients do not realize how much external hormonal inputs can affect long-term wellness and how these factors interact with scoliosis risk.

In this episode, we cover:
• How birth control pills can contribute to inflammation

• The differences between synthetic hormones and the hormones produced naturally by the body

• Research showing that certain synthetic hormones may be associated with increased cancer risk (contextual discussion, not individualized medical advice)

• Glyphosate as an environmental compound with estrogen-mimicking properties

• How birth control pills may provide symptom relief while potentially suppressing natural hormone production

• Why most children diagnosed with scoliosis have low body fat

• Why having low adipose tissue does not rule out metabolic or insulin-related problems

This episode sets the foundation for understanding how the endocrine system, metabolism, and environmental influences work together to shape long-term health outcomes.

Spinal flexibility is one of the most important factors in predicting scoliosis outcomes. It not only influences how much curve correction might be possible but also helps determine whether specific treatment approaches are worth pursuing.

In this episode, we discuss:

• How spinal flexibility helps set expectations for achievable improvement

• Why treatment intensity should match the likelihood of meaningful results

• How lying-down x-rays provide a clearer picture of true flexibility

• Why these specialized x-rays often need to be taken at specific imaging centers

• How Back Genius tools help identify whether bracing is likely to work or whether a patient may need other corrective strategies

• How a history of bracing can sometimes negatively impact surgical outcomes

• How Back Genius conservative programs may improve flexibility prior to surgery (potentially improving the results of surgical intervention)

Understanding flexibility early allows patients and families to make informed decisions and avoid unnecessary or ineffective treatment paths.

Scoliosis is commonly viewed as a structural issue of the spine, but the visible curve is often the final expression of deeper, systemic factors. In this episode, we focus on genomics and how it shapes both the likelihood of developing a curve and the way the body responds to treatment.

We discuss how:

Scoliosis is not primarily a spine problem (the curvature is the last thing that shows up)

A collection of genetic variants can increase the likelihood of curve development during rapid growth

Melatonin and serotonin pathways play a role in both postural reflex control and bone modulation

Genomic patterns help explain why two people with the same curve type often respond very differently to braces, exercise, therapy, or surgery

Long-term correction requires addressing the underlying reasons the curve formed, not just the visible structure

Genomics allows us to evaluate predetermined risk, personalize treatment strategies, and understand the origin of the curve rather than only managing its appearance.