Drs Tania Jain and Ruben Mesa discuss the clinical trials and the future of myelofibrosis research.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002053. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Myeloproliferative Neoplasms (MPNs) Have a Significant Impact on Patients’ Overall Health and Productivity: The MPN Landmark Survey https://pubmed.ncbi.nlm.nih.gov/26922064/

A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/22375971/

The Myelofibrosis Symptom Assessment Form (MFSAF): An Evidence-Based Brief Inventory to Measure Quality of Life and Symptomatic Response to Treatment in Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/19250674/

Practical Measures of Clinical Benefit With Ruxolitinib Therapy: An Exploratory Analysis of COMFORT-I https://pubmed.ncbi.nlm.nih.gov/28606598/

The Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF): International Prospective Validation and Reliability Trial in 402 Patients https://pubmed.ncbi.nlm.nih.gov/21536863/

Randomized, Single-Blind, Multicenter Phase II Study of Two Doses of Imetelstat in Relapsed or Refractory Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/34138638/

Phase III MANIFEST-2: Pelabresib + Ruxolitinib vs Placebo + Ruxolitinib in JAK Inhibitor Treatment-Naive Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/35950489/

Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis (TRANSFORM-2) https://clinicaltrials.gov/study/NCT04468984

Allogeneic Stem Cell Transplant for Patients With Myeloproliferative Neoplasms in Blast Phase: Improving Outcomes in the Recent Era https://pubmed.ncbi.nlm.nih.gov/33821472/

Efficacy and Safety of Ruxolitinib After and Versus Interferon Use in the RESPONSE Studies https://pubmed.ncbi.nlm.nih.gov/29396713/